KCNJ2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCNJ2_MOUSE
• UniProt AC: P35561
• Protein Name: Inward rectifier potassium channel 2
• Gene Name: Kcnj2
• Organism: Mus musculus (Mouse).
• Sequence Length: 428
• Subcellular Localization: Membrane; Multi-pass membrane protein. Membrane; Lipid-anchor .
• Protein Description: Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium..
• Protein Sequence: MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDTSKVSKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEEEDSENGVPESTSTDSPPGIDLHNQASVPLEPRPLRRESEI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGSVRTNRY ------CCCCCCCCE		-
3	Phosphorylation	-----MGSVRTNRYS -----CCCCCCCCEE		23375375
6	Phosphorylation	--MGSVRTNRYSIVS --CCCCCCCCEEEEE		23375375
9	Phosphorylation	GSVRTNRYSIVSSEE CCCCCCCEEEEECCC		29899451
10	Phosphorylation	SVRTNRYSIVSSEED CCCCCCEEEEECCCH		22817900
13	Phosphorylation	TNRYSIVSSEEDGMK CCCEEEEECCCHHHH		19144319
14	Phosphorylation	NRYSIVSSEEDGMKL CCEEEEECCCHHHHH		21183079
76	S-nitrosylation	LADIFTTCVDIRWRW HHHHHHHHHHHHHHH		-
76	S-nitrosocysteine	LADIFTTCVDIRWRW HHHHHHHHHHHHHHH		-
242	Phosphorylation	RITSEGEYIPLDQID CCCCCCCEEEHHHEE		-
336	Phosphorylation	VLFEEKHYYKVDYSR EECEEEEEEEEEHHH		25367039
337	Phosphorylation	LFEEKHYYKVDYSRF ECEEEEEEEEEHHHC		25367039
338	Ubiquitination	FEEKHYYKVDYSRFH CEEEEEEEEEHHHCC		22790023
346	Ubiquitination	VDYSRFHKTYEVPNT EEHHHCCCEEECCCC		22790023
347	Phosphorylation	DYSRFHKTYEVPNTP EHHHCCCEEECCCCC		-
348	Phosphorylation	YSRFHKTYEVPNTPL HHHCCCEEECCCCCC		-
391	Phosphorylation	SKEEEEDSENGVPES CHHHHHCCCCCCCCC		23737553
398	Phosphorylation	SENGVPESTSTDSPP CCCCCCCCCCCCCCC		23737553
399	Phosphorylation	ENGVPESTSTDSPPG CCCCCCCCCCCCCCC		23737553
400	Phosphorylation	NGVPESTSTDSPPGI CCCCCCCCCCCCCCC		23737553
401	Phosphorylation	GVPESTSTDSPPGID CCCCCCCCCCCCCCC		23737553
403	Phosphorylation	PESTSTDSPPGIDLH CCCCCCCCCCCCCCC		23737553

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KCNJ2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCNJ2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCNJ2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of KCNJ2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.