ATR1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATR1_YEAST
• UniProt AC: P13090
• Protein Name: Aminotriazole resistance protein
• Gene Name: ATR1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 542
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. Probable ATP-dependent export permease. Appears to confer resistance only to aminotriazole..
• Protein Sequence: MGNQSLVVLTESKGEYENETELPVKKSSRDNNIGESLTATAFTQSEDEMVDSNQKWQNPNYFKYAWQEYLFIFTCMISQLLNQAGTTQTLSIMNILSDSFGSEGNSKSWLMASFPLVSGSFILISGRLGDIYGLKKMLLVGYVLVIIWSLICGITKYSGSDTFFIISRAFQGLGIAFVLPNVLGIIGNIYVGGTFRKNIVISFVGAMAPIGATLGCLFAGLIGTEDPKQWPWAFYAYSIAAFINFVLSIYAIPSTIPTNIHHFSMDWIGSVLGVIGLILLNFVWNQAPISGWNQAYIIVILIISVIFLVVFIIYEIRFAKTPLLPRAVIKDRHMIQIMLALFFGWGSFGIFTFYYFQFQLNIRQYTALWAGGTYFMFLIWGIIAALLVGFTIKNVSPSVFLFFSMVAFNVGSIMASVTPVHETYFRTQLGTMIILSFGMDLSFPASSIIFSDNLPMEYQGMAGSLVNTVVNYSMSLCLGMGATVETQVNSDGKHLLKGYRGAQYLGIGLASLACMISGLYMVESFIKGRRARAAAEYDCTVA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MGNQSLVVLTES ---CCCEEEEEEECC	27.42	28152593
10	Phosphorylation	NQSLVVLTESKGEYE CEEEEEEECCCCCCC	26.97	27017623
12	Phosphorylation	SLVVLTESKGEYENE EEEEEECCCCCCCCC	40.50	22369663
25	Ubiquitination	NETELPVKKSSRDNN CCCCCCCCCCCCCCC	45.02	23749301
43	Phosphorylation	SLTATAFTQSEDEMV CCEEEEECCCHHHCC	28.81	20377248
45	Phosphorylation	TATAFTQSEDEMVDS EEEEECCCHHHCCCC	43.91	20377248
471	N-linked_Glycosylation	SLVNTVVNYSMSLCL HHHHHHHHHHHHHHH	20.87	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ATR1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATR1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATR1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APC11_YEAST	APC11	genetic	27708008
SMD1_YEAST	SMD1	genetic	27708008
MCM1_YEAST	MCM1	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5; SER-12; THR-43 ANDSER-45, AND MASS SPECTROMETRY.
PubMed: 18407956