| UniProt ID | PCL5_YEAST | |
|---|---|---|
| UniProt AC | P38794 | |
| Protein Name | PHO85 cyclin-5 | |
| Gene Name | PCL5 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 229 | |
| Subcellular Localization | ||
| Protein Description | Cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Positively controls degradation of transcription factor GCN4 under favorable growth conditions. The PCL5-PHO85 cyclin-CDK holoenzyme phosphorylates GCN4, which is required for its degradation by the E3 ubiquitin ligase complex SCF(Cdc4). Amino acid starvation reduces PCL5-PHO85-associated GCN4 kinase activity and leads to stabilization of GCN4.. | |
| Protein Sequence | MDGNHRFTPDSKEFNTVVKSKESSTGRNPYQTPPLEHNGTHHQTNYSRKKTNLAIIISNFLSEISRPLSNGKINNSTHNILKFLNEVLKRSKCSKENAVLATFYFQKIHQSRGVRDESSLPEFSHCSRRIFLCCLILSHKFLNDNTYSMKNWQIISGLHAKDLSLMERWCLGKLNYELAIPYDEFLLWETNTLMKAKLRVGTPANAPVKRPRESDNDYDANSWKQIKSC | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 32 | Phosphorylation | TGRNPYQTPPLEHNG CCCCCCCCCCCCCCC | 22.49 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PCL5_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PCL5_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PCL5_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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