dbPTM

RRT14_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RRT14_YEAST
UniProt AC	P40470
Protein Name	Regulator of rDNA transcription protein 14
Gene Name	RRT14
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	206
Subcellular Localization	Nucleus, nucleolus .
Protein Description	Involved in ribosome biogenesis, probably through modulation of rDNA transcription..
Protein Sequence	MSSSLSQTSKYQATSVVNGLLSNLLPGVPKIRANNGKTSVNNGSKAQLIDRNLKKRVQLQNRDVHKIKKKCKLVKKKKVKKHKLDKEQLEQLAKHQVLKKHQHEGTLTDHERKYLNKLIKRNSQNLRSWDLEEEVRDELEDIQQSILKDTVSTANTDRSKRRRFKRKQFKEDIKESDFVKDHRYPGLTPGLAPVGLSDEEDSSEED

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MSSSLSQTSKYQA --CCCCCCCCCHHHH	33.10	30377154
44	Phosphorylation	KTSVNNGSKAQLIDR CCCCCCCCHHHHHCC	27.26	23749301
123	Phosphorylation	NKLIKRNSQNLRSWD HHHHHHCCCCHHCCC	25.20	30377154
184	Phosphorylation	DFVKDHRYPGLTPGL CCCCCCCCCCCCCCC	9.76	19795423
188	Phosphorylation	DHRYPGLTPGLAPVG CCCCCCCCCCCCCCC	22.64	19795423
197	Phosphorylation	GLAPVGLSDEEDSSE CCCCCCCCCCCCCCC	36.73	19823750
202	Phosphorylation	GLSDEEDSSEED--- CCCCCCCCCCCC---	42.82	21440633
203	Phosphorylation	LSDEEDSSEED---- CCCCCCCCCCC----	58.28	17563356

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RRT14_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RRT14_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RRT14_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ADK_YEAST	ADO1	physical	16554755
SNF5_YEAST	SNF5	genetic	27708008
PP2C1_YEAST	PTC1	genetic	27708008
HSP78_YEAST	HSP78	genetic	27708008
INO4_YEAST	INO4	genetic	27708008
CDC27_YEAST	CDC27	genetic	27708008
ENP1_YEAST	ENP1	genetic	27708008
TRS20_YEAST	TRS20	genetic	27708008
FBRL_YEAST	NOP1	genetic	27708008
RRP42_YEAST	RRP42	genetic	27708008
NOP14_YEAST	NOP14	genetic	27708008
UBC3_YEAST	CDC34	genetic	27708008
GPI8_YEAST	GPI8	genetic	27708008
UTP6_YEAST	UTP6	genetic	27708008
RMRP_YEAST	SNM1	genetic	27708008
SMT3_YEAST	SMT3	genetic	27708008
CDC20_YEAST	CDC20	genetic	27708008
RRP41_YEAST	SKI6	genetic	27708008
BCD1_YEAST	BCD1	genetic	27708008
RRP3_YEAST	RRP3	genetic	27708008
UTP9_YEAST	UTP9	genetic	27708008
DCA13_YEAST	SOF1	genetic	27708008
NEP1_YEAST	EMG1	genetic	27708008
UTP13_YEAST	UTP13	genetic	27708008
DBP9_YEAST	DBP9	genetic	27708008
UTP15_YEAST	UTP15	genetic	27708008
HAS1_YEAST	HAS1	genetic	27708008
NAT10_YEAST	KRE33	genetic	27708008
RRP44_YEAST	DIS3	genetic	27708008
NUF2_YEAST	NUF2	genetic	27708008
MYO2_YEAST	MYO2	genetic	27708008
ATC3_YEAST	DRS2	genetic	27708008
SWC5_YEAST	SWC5	genetic	27708008
SHG1_YEAST	SHG1	genetic	27708008
NOP6_YEAST	NOP6	genetic	27708008
DOS2_YEAST	DOS2	genetic	27708008
RRP8_YEAST	RRP8	genetic	27708008
NBP2_YEAST	NBP2	genetic	27708008
VHS1_YEAST	VHS1	genetic	27708008
DIN7_YEAST	DIN7	genetic	27708008
IES1_YEAST	IES1	genetic	27708008
PUF4_YEAST	PUF4	genetic	27708008
NCA3_YEAST	NCA3	genetic	27708008
SAC1_YEAST	SAC1	genetic	27708008
CMS1_YEAST	CMS1	genetic	27708008
ELO3_YEAST	ELO3	genetic	27708008
YNO0_YEAST	YNL140C	genetic	27708008
RRP6_YEAST	RRP6	genetic	27708008
SUR1_YEAST	SUR1	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RRT14_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197 AND SER-203, ANDMASS SPECTROMETRY.	17563356 [Abstract]