CAN_YEAST - dbPTM
CAN_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CAN_YEAST
UniProt AC P53615
Protein Name Carbonic anhydrase
Gene Name NCE103
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 221
Subcellular Localization Cytoplasm . Nucleus . Mitochondrion intermembrane space .
Protein Description Catalyzes the reversible hydration of CO(2) to H(2)CO(3). The main role may be to provide inorganic carbon for the bicarbonate-dependent carboxylation reactions catalyzed by pyruvate carboxylase, acetyl-CoA carboxylase and carbamoyl-phosphate synthetase. Involved in protection against oxidative damage. Encodes a substrate for the non-classical protein export pathway for proteins that lack a cleavable signal sequence..
Protein Sequence MSATESSSIFTLSHNSNLQDILAANAKWASQMNNIQPTLFPDHNAKGQSPHTLFIGCSDSRYNENCLGVLPGEVFTWKNVANICHSEDLTLKATLEFAIICLKVNKVIICGHTDCGGIKTCLTNQREALPKVNCSHLYKYLDDIDTMYHEESQNLIHLKTQREKSHYLSHCNVKRQFNRIIENPTVQTAVQNGELQVYGLLYNVEDGLLQTVSTYTKVTPK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSATESSSI
------CCCCCCCCE		43.8530377154
4Phosphorylation----MSATESSSIFT
----CCCCCCCCEEE		29.1530377154
8PhosphorylationMSATESSSIFTLSHN
CCCCCCCCEEEECCC		30.8830377154
11PhosphorylationTESSSIFTLSHNSNL
CCCCCEEEECCCCCH		26.1930377154
27UbiquitinationDILAANAKWASQMNN
HHHHHHHHHHHHCCC		43.0017644757
46UbiquitinationLFPDHNAKGQSPHTL
CCCCCCCCCCCCCEE		63.9017644757
78UbiquitinationPGEVFTWKNVANICH
CCCEEEEECHHHHHC		38.1917644757
92UbiquitinationHSEDLTLKATLEFAI
CCCCCCHHHHEEHHH		33.8117644757
103UbiquitinationEFAIICLKVNKVIIC
EHHHHHEECCEEEEE		39.0717644757
106UbiquitinationIICLKVNKVIICGHT
HHHEECCEEEEECCC		37.4917644757
119UbiquitinationHTDCGGIKTCLTNQR
CCCCCCHHHHHCCCH		36.1423749301
131UbiquitinationNQREALPKVNCSHLY
CCHHHCCCCCHHHHH		47.1023749301
139UbiquitinationVNCSHLYKYLDDIDT
CCHHHHHHHHHHHHH		45.7723749301
159UbiquitinationSQNLIHLKTQREKSH
HCCEEECCHHHHHHH		28.5717644757
164UbiquitinationHLKTQREKSHYLSHC
ECCHHHHHHHHHHHC		44.7317644757
174UbiquitinationYLSHCNVKRQFNRII
HHHHCCHHHHHHHHH		26.8717644757
217UbiquitinationQTVSTYTKVTPK---
EEEEEEEECCCC---		33.4315699485
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseHEYL-
PMID:31789040
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CAN_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CAN_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CAN_YEASTNCE103physical
19852838
CDC7_YEASTCDC7genetic
27708008
ERF3_YEASTSUP35genetic
27708008
MOB2_YEASTMOB2genetic
27708008
BRL1_YEASTBRL1genetic
27708008
TFC3_YEASTTFC3genetic
27708008
ERD2_YEASTERD2genetic
27708008
TFC1_YEASTTFC1genetic
27708008
POP7_YEASTPOP7genetic
27708008
TRS20_YEASTTRS20genetic
27708008
RPC10_YEASTRPC11genetic
27708008
TCPZ_YEASTCCT6genetic
27708008
TFC6_YEASTTFC6genetic
27708008
RPB7_YEASTRPB7genetic
27708008
COG3_YEASTCOG3genetic
27708008
PRP43_YEASTPRP43genetic
27708008
PRP38_YEASTPRP38genetic
27708008
DAM1_YEASTDAM1genetic
27708008
NUP57_YEASTNUP57genetic
27708008
PAN1_YEASTPAN1genetic
27708008
RPC9_YEASTRPC17genetic
27708008
KRE9_YEASTKRE9genetic
27708008
PRI2_YEASTPRI2genetic
27708008
SN114_YEASTSNU114genetic
27708008
PRP19_YEASTPRP19genetic
27708008
BOS1_YEASTBOS1genetic
27708008
RU1C_YEASTYHC1genetic
27708008
SC61A_YEASTSEC61genetic
27708008
SEC39_YEASTSEC39genetic
27708008
SEC65_YEASTSEC65genetic
27708008
MED11_YEASTMED11genetic
27708008
HRP1_YEASTHRP1genetic
27708008
SGT1_YEASTSGT1genetic
27708008
RPC1_YEASTRPO31genetic
27708008
TFC8_YEASTTFC8genetic
27708008
ARP7_YEASTARP7genetic
27708008
TF2B_YEASTSUA7genetic
27708008
RPC3_YEASTRPC82genetic
27708008
SWC3_YEASTSWC3genetic
27708008
ATC3_YEASTDRS2genetic
27708008
SHE1_YEASTSHE1genetic
27708008
RS8A_YEASTRPS8Agenetic
27708008
RS8B_YEASTRPS8Agenetic
27708008
PYC2_YEASTPYC2genetic
27708008
SWC5_YEASTSWC5genetic
27708008
YCY0_YEASTYCR090Cgenetic
27708008
GPR1_YEASTGPR1genetic
27708008
SOK1_YEASTSOK1genetic
27708008
TPS2_YEASTTPS2genetic
27708008
SAC3_YEASTSAC3genetic
27708008
UME6_YEASTUME6genetic
27708008
SWR1_YEASTSWR1genetic
27708008
PSP1_YEASTPSP1genetic
27708008
AIM11_YEASTAIM11genetic
27708008
RAD4_YEASTRAD4genetic
27708008
RSSA1_YEASTRPS0Agenetic
27708008
REXO1_YEASTRNH70genetic
27708008
OCA5_YEASTOCA5genetic
27708008
RPN10_YEASTRPN10genetic
27708008
YIF4_YEASTYIL054Wgenetic
27708008
XPOT_YEASTLOS1genetic
27708008
ARP6_YEASTARP6genetic
27708008
SST2_YEASTSST2genetic
27708008
RAD10_YEASTRAD10genetic
27708008
FYV12_YEASTFYV12genetic
27708008
TGS1_YEASTTGS1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CAN_YEAST

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Related Literatures of Post-Translational Modification

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