YRF17_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YRF17_YEAST
• UniProt AC: P0CX15
• Protein Name: Y' element ATP-dependent helicase protein 1 copy 7
• Gene Name: YRF1-7
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 1859
• Protein Description: Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance..
• Protein Sequence: MEIENEQICTCIAQILHLLNSLIITFLDDDKTETGQSFVYIDGFLVKKHNNQHTIVNFETYKNKMKVSDRRKFEKANFDEFESALNNKNDLVHCPSITLFESIPTEVRSFYEDEKSGLIKVVKFRTGAMDRKRSFEKIVVSVMVGKNVQKFLTFVEDEPDFQGGPIPSKYLIPKKINLMVYTLFQVHTLKFNRKDYDTLSLFYLNRGYYNELSFRVLERCYEIASARPNDSSTMRTFTDFVSGTPIVRGLQKSTIRKYGYNLAPYMFLLLHVDELSIFSAYQASLPGEKKVDTERLKRDLCPRKPTEIKYFSQICNDMMNKKDRLGDILHIILRACALNFGAGPRGGAGDEEDRSITNEEPIIPSVDEHGLKVCKLRSPNTPRRLRKTLDAVKALLVSSCACTARDLDIFDDNNGVAMWKWIKILYHEVAQETALKDSYRITLVPSSDGVSVCGKLFNREYVRGFYFACKAQFDNLWEELNDCFYMPTVVDIASLILRNREVLFREPKRGIDEYLENDSFLQMIPVKYREIVLPKLRRDTNKMTAALKNKVTVAIDELTVPLMWMIHFAVGYPYRYPELQLLAFAGPQRNVYVDDTTRRIQLYTDYNKNGSSEPRLKTLDGLTSDYVFYFVTVLRQMQICALGNSYDAFNHDPWMDVVGFEDPDQVTNRDISRIVLYSYMFLNTAKGCLVEYATFRQYMRELPKNAPQKLNFREMRQGLIALGRHCVGSRFETDLYESATSELMANHSVQTGRNIYGVDSFSLTSVSGTTATLLQERASERWIQWLGLESDYHCSFSSTRNAEDVVAGEAASSDHHQKISRVTRKRPREPKSTNDILVAGQKLFGSSFEFRDLHQLRLCHEIYMADTPSVAVQAPPGYGKTELFHLPLIALASKGDVKYVSFLFVPYTVLLANCMIRLSRCGCLNVAPVRNFIEEGCDGVTDLYVGIYDDLASTNFTDRIAAWENIVECTFRTNNVKLGYLIVDEFHNFETEVYRQSQFGGITNLDFDAFEKAIFLSGTAPEAVADAALQRIGLTGLAKKSMDINELKRSEDLSRGLSSYPTRMFNLIKEKSEVPLGHVHKIWKKVESQPEEALKLLLALFEIEPESKAIVVASTTNEVEELACSWRKYFRVVWIHGKLGAAEKVSRTKEFVTDGSMRVLIGTKLVTEGIDIKQLMMVIMLDNRLNIIELIQGVGRLRDGGLCYLLSRKNSWAARNRKGELPPIKEGCITEQVREFYGLESKKGKKGQHVGCCGSRTDLSADTVELIERMDRLAEKQATASMSIVALPSSFQESNSSDRCRKYCSSDEDSDTCIHGSANASTNATTNSSTNATTTASTNVRTSATTTASINVRTSATTTESTNSSTNATTTASTNVRTSATTTASINVRTSATTTESTNSNTSATTTESTDSNTSATTTESTDSNTSATTTASTNSSTNATTTASTNSSTNATTTESTNASAKEDANKDGNAEDNRFHPVTDINKESYKRKGSQMVLLERKKLKAQFPNTSENMNVLQFLGFRSDEIKHLFLYGIDVYFCPEGVFTQYGLCKGCQKMFELCVCWAGQKVSYRRMAWEALAVERMLRNDEEYKEYLEDIEPYHGDPVGYLKYFSVKRGEIYSQIQRNYAWYLAITRRRETISVLDSTRGKQGSQVFRMSGRQIKELYYKVWSNLRESKTEVLQYFLNWDEKKCREEWEAKDDTVFVEALEKVGVFQRLRSMTSAGLQGPQYVKLQFSRHHRQLRSRYELSLGMHLRDQLALGVTPSKVPHWTAFLSMLIGLFCNKTFRQKLEYLLEQISEVWLLPHWLDLANVEVLAADNTRVPLYMLMVAVHKELDSDDVPDGRFDILLCRDSSREVGE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
47	Ubiquitination	YIDGFLVKKHNNQHT EEEEEEEEECCCCCE	50.92	17644757
48	Ubiquitination	IDGFLVKKHNNQHTI EEEEEEEECCCCCEE	44.05	17644757
62	Ubiquitination	IVNFETYKNKMKVSD EEECCHHCCCCCHHH	58.47	17644757
75	Ubiquitination	SDRRKFEKANFDEFE HHHHHHHHCCHHHHH	52.33	17644757
88	Ubiquitination	FESALNNKNDLVHCP HHHHHCCCCCCCCCC	51.25	17644757
355	Phosphorylation	AGDEEDRSITNEEPI CCCHHHCCCCCCCCC	46.19	19779198
420	Ubiquitination	NNGVAMWKWIKILYH CCCEEHHHHHHHHHH	26.42	17644757
423	Ubiquitination	VAMWKWIKILYHEVA EEHHHHHHHHHHHHH	26.08	17644757
436	Ubiquitination	VAQETALKDSYRITL HHHHHHCCCCEEEEE	42.01	17644757
438	Phosphorylation	QETALKDSYRITLVP HHHHCCCCEEEEEEE	18.09	27017623
439	Phosphorylation	ETALKDSYRITLVPS HHHCCCCEEEEEEEC	19.03	27017623
542	Ubiquitination	KLRRDTNKMTAALKN HHCCCCHHHHHHHHC	39.46	23749301
608	Ubiquitination	QLYTDYNKNGSSEPR EEECCCCCCCCCCCC	57.36	17644757
704	Ubiquitination	QYMRELPKNAPQKLN HHHHHCCCCCCCCCC	77.64	23749301
760	Phosphorylation	RNIYGVDSFSLTSVS CCEECCCCCEEEECC	17.83	27214570
767	Phosphorylation	SFSLTSVSGTTATLL CCEEEECCCCHHHHH	30.14	27214570
977	Ubiquitination	TFRTNNVKLGYLIVD EEECCCEEEEEEEEE	38.01	17644757
1012	Ubiquitination	LDFDAFEKAIFLSGT CCHHHHHHHHHHCCC	40.09	17644757
1069	Ubiquitination	TRMFNLIKEKSEVPL HHHHHHHHHCCCCCC	63.36	17644757
1071	Ubiquitination	MFNLIKEKSEVPLGH HHHHHHHCCCCCCCH	47.08	17644757
1081	Ubiquitination	VPLGHVHKIWKKVES CCCCHHHHHHHHHHC	49.53	17644757
1084	Ubiquitination	GHVHKIWKKVESQPE CHHHHHHHHHHCCHH	50.87	17644757
1085	Ubiquitination	HVHKIWKKVESQPEE HHHHHHHHHHCCHHH	35.92	17644757
1095	Ubiquitination	SQPEEALKLLLALFE CCHHHHHHHHHHHHC	44.10	17644757
1211	Phosphorylation	YLLSRKNSWAARNRK EEEECCCCHHHHCCC	22.56	27214570
1245	Ubiquitination	GLESKKGKKGQHVGC CCCCCCCCCCCEECC	63.71	17644757
1246	Ubiquitination	LESKKGKKGQHVGCC CCCCCCCCCCEECCC	72.91	17644757
1294	Phosphorylation	LPSSFQESNSSDRCR CCCCCCCCCCCHHHH	31.09	28889911
1296	Phosphorylation	SSFQESNSSDRCRKY CCCCCCCCCHHHHHH	42.78	28889911
1297	Phosphorylation	SFQESNSSDRCRKYC CCCCCCCCHHHHHHC	33.07	28889911
1337	Phosphorylation	TNATTTASTNVRTSA CCCEECCCCEEECCE	20.58	28889911
1342	Phosphorylation	TASTNVRTSATTTAS CCCCEEECCEEEEEE	20.59	27017623
1347	Phosphorylation	VRTSATTTASINVRT EECCEEEEEEEEEEC	17.66	27017623
1364	Phosphorylation	TTTESTNSSTNATTT EECCCCCCCCCCEEE	38.33	29688323
1365	Phosphorylation	TTESTNSSTNATTTA ECCCCCCCCCCEEEE	27.96	29688323
1366	Phosphorylation	TESTNSSTNATTTAS CCCCCCCCCCEEEEE	28.79	29688323
1369	Phosphorylation	TNSSTNATTTASTNV CCCCCCCEEEEECCE	27.09	29688323
1370	Phosphorylation	NSSTNATTTASTNVR CCCCCCEEEEECCEE	20.25	29688323
1371	Phosphorylation	SSTNATTTASTNVRT CCCCCEEEEECCEEC	17.79	29688323
1373	Phosphorylation	TNATTTASTNVRTSA CCCEEEEECCEECCE	20.58	28889911
1374	Phosphorylation	NATTTASTNVRTSAT CCEEEEECCEECCEE	34.96	29688323
1378	Phosphorylation	TASTNVRTSATTTAS EEECCEECCEEEEEE	20.59	27017623
1383	Phosphorylation	VRTSATTTASINVRT EECCEEEEEEEEEEE	17.66	27017623
1453	Phosphorylation	TNSSTNATTTESTNA CCCCCCCCCCCCCCC	36.00	27017623
1455	Phosphorylation	SSTNATTTESTNASA CCCCCCCCCCCCCHH	24.47	27017623
1458	Phosphorylation	NATTTESTNASAKED CCCCCCCCCCHHCHH	28.68	27017623
1491	Ubiquitination	NKESYKRKGSQMVLL CHHHHHCCCCEEEEE	59.78	17644757
1493	Phosphorylation	ESYKRKGSQMVLLER HHHHCCCCEEEEEEH	20.38	25752575
1501	Ubiquitination	QMVLLERKKLKAQFP EEEEEEHHHHHHHCC	53.75	17644757
1504	Ubiquitination	LLERKKLKAQFPNTS EEEHHHHHHHCCCCC	49.36	17644757
1610	Ubiquitination	GDPVGYLKYFSVKRG CCCCCEEEEEEEECC	35.45	24961812
1615	Ubiquitination	YLKYFSVKRGEIYSQ EEEEEEEECCCHHHH	54.19	17644757
1649	Ubiquitination	VLDSTRGKQGSQVFR EECCCCCCCCCEEEE	48.47	23749301
1719	Phosphorylation	GVFQRLRSMTSAGLQ CHHHHHHHCCCCCCC	30.88	27017623
1730	Phosphorylation	AGLQGPQYVKLQFSR CCCCCCCEEEEEECH	11.59	27017623
1732	Ubiquitination	LQGPQYVKLQFSRHH CCCCCEEEEEECHHH	31.47	24961812

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of YRF17_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YRF17_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YRF17_YEAST !!

Protein-Protein Interaction

Oops, there are no PPI records of YRF17_YEAST !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.