PURA_YEAST - dbPTM
PURA_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PURA_YEAST
UniProt AC P80210
Protein Name Adenylosuccinate synthetase {ECO:0000255|HAMAP-Rule:MF_03125}
Gene Name ADE12 {ECO:0000255|HAMAP-Rule:MF_03125}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 433
Subcellular Localization Cytoplasm .
Protein Description Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP..
Protein Sequence MVNVVLGSQWGDEGKGKLVDLLVGKYDIVARCAGGNNAGHTIVVDGVKYDFHMLPSGLVNPNCQNLLGNGVVIHVPSFFKELETLEAKGLKNARSRLFVSSRAHLVFDFHQVTDKLRELELSGRSKDGKNIGTTGKGIGPTYSTKASRSGLRVHHLVNDQPGAWEEFVARYKRLLETRRQRYGDFEYDFEAKLAEYKKLREQLKPFVVDSVVFMHNAIEAKKKILVEGANALMLDIDFGTYPYVTSSNTGIGGVLTGLGIPPRTIDEIYGVVKAYTTRVGEGPFPTEQLNENGEKLQTIGAEFGVTTGRKRRCGWLDLVVLKYSTLINGYTSLNITKLDVLDTFKEIPVGISYSIQGKKLDLFPEDLNILGKVEVEYKVLPGWDQDITKITKYEDLPENAKKYLKYIEDFVGVPVEWVGTGPARESMLHKEIK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
17AcetylationWGDEGKGKLVDLLVG
CCCCCCCHHHHHHCC		49.1524489116
25AcetylationLVDLLVGKYDIVARC
HHHHHCCCCEEEEEE		32.0724489116
88AcetylationELETLEAKGLKNARS
HHHHHHHCCCCCHHH		56.2324489116
115AcetylationDFHQVTDKLRELELS
EHHHHHHHHHHHHHC		39.8324489116
122PhosphorylationKLRELELSGRSKDGK
HHHHHHHCCCCCCCC		23.8428889911
125PhosphorylationELELSGRSKDGKNIG
HHHHCCCCCCCCCCC		38.3324961812
141PhosphorylationTGKGIGPTYSTKASR
CCCCCCCCCCCCCCC		25.5421126336
143PhosphorylationKGIGPTYSTKASRSG
CCCCCCCCCCCCCCC		26.3827214570
1452-HydroxyisobutyrylationIGPTYSTKASRSGLR
CCCCCCCCCCCCCCE		38.12-
1972-HydroxyisobutyrylationEAKLAEYKKLREQLK
HHHHHHHHHHHHHHC		36.52-
275PhosphorylationIYGVVKAYTTRVGEG
HHHHHHHHCCCCCCC		11.7023607784
276PhosphorylationYGVVKAYTTRVGEGP
HHHHHHHCCCCCCCC		17.0023607784
277PhosphorylationGVVKAYTTRVGEGPF
HHHHHHCCCCCCCCC		15.6423607784
286PhosphorylationVGEGPFPTEQLNENG
CCCCCCCHHHCCCCC		36.4223607784
3582-HydroxyisobutyrylationISYSIQGKKLDLFPE
EEEEECCEEEECCHH		33.51-
378AcetylationGKVEVEYKVLPGWDQ
CEEEEEEEECCCCCC		24.6424489116
389AcetylationGWDQDITKITKYEDL
CCCCCHHHHCCHHHC		49.0324489116
392AcetylationQDITKITKYEDLPEN
CCHHHHCCHHHCCHH		50.5522865919
3922-HydroxyisobutyrylationQDITKITKYEDLPEN
CCHHHHCCHHHCCHH		50.55-
426PhosphorylationGTGPARESMLHKEIK
CCCCHHHHHHCHHCC		22.5321440633
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PURA_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PURA_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PURA_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
REG1_YEASTREG1physical
16554755
EFTU_YEASTTUF1physical
16554755
HSP71_YEASTSSA1physical
19536198
APT1_YEASTAPT1genetic
16941010
APT2_YEASTAPT2genetic
16941010
ADK_YEASTADO1genetic
16941010
ITPA_YEASTHAM1genetic
22308425
BUD31_YEASTBUD31genetic
27708008
PHO2_YEASTPHO2genetic
27708008
RL35A_YEASTRPL35Agenetic
27708008
RL35B_YEASTRPL35Agenetic
27708008
EF2_YEASTEFT2genetic
27708008
PUR3_YEASTADE8genetic
27708008
PUR2_YEASTADE5,7genetic
27708008
EIF2A_YEASTYGR054Wgenetic
27708008
PUR4_YEASTADE6genetic
27708008
DAL81_YEASTDAL81genetic
27708008
RS21A_YEASTRPS21Agenetic
27708008
PFKA2_YEASTPFK2genetic
27708008
TOP1_YEASTTOP1genetic
27708008
YAR1_YEASTYAR1genetic
27708008
ATC3_YEASTDRS2genetic
27708008
PEX22_YEASTPEX22genetic
27708008
PUR7_YEASTADE1genetic
27708008
PIN4_YEASTPIN4genetic
27708008
TOD6_YEASTTOD6genetic
27708008
KPR4_YEASTPRS4genetic
27708008
ECM8_YEASTECM8genetic
27708008
GID4_YEASTVID24genetic
27708008
NGR1_YEASTNGR1genetic
27708008
ISW1_YEASTISW1genetic
27708008
DPH7_YEASTRRT2genetic
27708008
EFM2_YEASTEFM2genetic
27708008
OCA4_YEASTOCA4genetic
27708008
SLX5_YEASTSLX5genetic
27708008
BRE1_YEASTBRE1genetic
27708008
AIR2_YEASTAIR2genetic
27708008
SNQ2_YEASTSNQ2genetic
27708008
DET1_YEASTDET1genetic
27708008
OCA6_YEASTOCA6genetic
27708008
RAD55_YEASTRAD55genetic
27708008
GIS1_YEASTGIS1genetic
27708008
UME6_YEASTUME6genetic
27708008
PEX5_YEASTPEX5genetic
27708008
RMD5_YEASTRMD5genetic
27708008
PEX10_YEASTPEX10genetic
27708008
RT103_YEASTRTT103genetic
27708008
IPK1_YEASTIPK1genetic
27708008
PEX3_YEASTPEX3genetic
27708008
YPQ2_YEASTYPQ2genetic
27708008
XRS2_YEASTXRS2genetic
27708008
SNF1_YEASTSNF1genetic
27708008
PSP1_YEASTPSP1genetic
27708008
FCY2_YEASTFCY2genetic
27708008
METE_YEASTMET6genetic
27708008
CHD1_YEASTCHD1genetic
27708008
ODPA_YEASTPDA1genetic
27708008
FTHC_YEASTFAU1genetic
27708008
BUD27_YEASTBUD27genetic
27708008
SA155_YEASTSAP155genetic
27708008
MIG1_YEASTMIG1genetic
27708008
PAN2_YEASTPAN2genetic
27708008
AAKG_YEASTSNF4genetic
27708008
ITC1_YEASTITC1genetic
27708008
PEX14_YEASTPEX14genetic
27708008
MDM34_YEASTMDM34genetic
27708008
VID30_YEASTVID30genetic
27708008
PEX8_YEASTPEX8genetic
27708008
YG2G_YEASTYGR079Wgenetic
27708008
UBCX_YEASTPEX4genetic
27708008
GTR2_YEASTGTR2genetic
27708008
UBR1_YEASTUBR1genetic
27708008
G3P3_YEASTTDH3genetic
27708008
SNF6_YEASTSNF6genetic
27708008
OCA5_YEASTOCA5genetic
27708008
SDO1L_YEASTRTC3genetic
27708008
VID28_YEASTVID28genetic
27708008
EMC5_YEASTEMC5genetic
27708008
TED1_YEASTTED1genetic
27708008
ICE2_YEASTICE2genetic
27708008
FYV10_YEASTFYV10genetic
27708008
HOS4_YEASTHOS4genetic
27708008
RPE_YEASTRPE1genetic
27708008
F26_YEASTFBP26genetic
27708008
DPOD3_YEASTPOL32genetic
27708008
PAN3_YEASTPAN3genetic
27708008
MAOM_YEASTMAE1genetic
27708008
AIM26_YEASTAIM26genetic
27708008
CTK1_YEASTCTK1genetic
27708008
LST4_YEASTLST4genetic
27708008
PEX1_YEASTPEX1genetic
27708008
MEH1_YEASTMEH1genetic
27708008
DBP7_YEASTDBP7genetic
27708008
MMM1_YEASTMMM1genetic
27708008
GLYC_YEASTSHM2genetic
27708008
ALAM_YEASTALT1genetic
27708008
PUS5_YEASTPUS5genetic
27708008
UPS2_YEASTUPS2genetic
27708008
PEX13_YEASTPEX13genetic
27708008
YL287_YEASTYLR287Cgenetic
27708008
VRP1_YEASTVRP1genetic
27708008
VIP1_YEASTVIP1genetic
27708008
PPZ1_YEASTPPZ1genetic
27708008
DATI_YEASTDAT1genetic
27708008
GTR1_YEASTGTR1genetic
27708008
PEX12_YEASTPEX12genetic
27708008
FAR8_YEASTFAR8genetic
27708008
RCO1_YEASTRCO1genetic
27708008
PUR92_YEASTADE17genetic
27708008
GID8_YEASTGID8genetic
27708008
SIW14_YEASTSIW14genetic
27708008
ATP23_YEASTATP23genetic
27708008
PEX15_YEASTPEX15genetic
27708008
KPR5_YEASTPRS5genetic
27708008
MET22_YEASTMET22genetic
27708008
IRA2_YEASTIRA2genetic
27708008
VAM10_YEASTVAM10genetic
27708008
VPS17_YEASTVPS17genetic
27708008
IES4_YEASTIES4genetic
27708008
NACB1_YEASTEGD1genetic
27708008
FUMH_YEASTFUM1genetic
27708008
YMC1_YEASTYMC1genetic
27708008
LDB19_YEASTLDB19genetic
27811238
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PURA_YEAST

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-122 AND SER-143, ANDMASS SPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory