SEN34_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SEN34_YEAST
• UniProt AC: P39707
• Protein Name: tRNA-splicing endonuclease subunit SEN34
• Gene Name: SEN34
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 275
• Subcellular Localization: Nucleus . Endomembrane system ; Peripheral membrane protein . Mitochondrion outer membrane ; Peripheral membrane protein ; Cytoplasmic side . The tRNA splicing endonuclease complex is predominantly associated with the outer membrane of mitochondria,
• Protein Description: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage..
• Protein Sequence: MPPLVFDIDHIKLLRKWGICGVLSGTLPTAAQQNVFLSVPLRLMLEDVLWLHLNNLADVKLIRQEGDEIMEGITLERGAKLSKIVNDRLNKSFEYQRKFKKDEHIAKLKKIGRINDKTTAEELQRLDKSSNNDQLIESSLFIDIANTSMILRDIRSDSDSLSRDDISDLLFKQYRQAGKMQTYFLYKALRDQGYVLSPGGRFGGKFIAYPGDPLRFHSHLTIQDAIDYHNEPIDLISMISGARLGTTVKKLWVIGGVAEETKETHFFSIEWAGFG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Oops, there are no PTM records of SEN34_YEAST !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SEN34_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SEN34_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SEN34_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SEN15_YEAST	SEN15	physical	9200603
SLS1_YEAST	SLS1	genetic	19061648
YPT6_YEAST	YPT6	genetic	19061648
PFD5_YEAST	GIM5	genetic	19061648

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.