YRF12_YEAST - dbPTM
YRF12_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID YRF12_YEAST
UniProt AC P40105
Protein Name Y' element ATP-dependent helicase protein 1 copy 2
Gene Name YRF1-2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1681
Subcellular Localization
Protein Description Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance..
Protein Sequence MVYTLFQVHTLKFNRKDYDTLSLFYLNRGYYNELSFRVLERCHEKASARPNDSSTMRTFTDFVSGAPIVRSLQKSTIRKYGYNLAPYMFLLLHVDELSIFSAYQASLPGEKKVDTERLKRDLCPRKPTEIKYFSQICNDMMNKKDRLGDILHIILRACALNFGAGPRGGAGDEEDRSITNEEPIIPSVDEHGLKVCKLRSPNTPRRLRKTLDAVKALLVSSCACTARDLDIFDDNNGVAMWKWIKILYHEVAQETALKDSYRITLVPSSDGVSVCGKLFNREYVRGFYFACKAQFDNLWEELNDCFYMPTVVDIASLILRNREVLFREPKRGIDEYLENDSFLQMIPVKYREIVLPKLRRDTNKMTAALKNKVTVAIDELTVPLMWMIHFAVGYPYRYPELQLLAFAGPQRNVYVDDTTRRIQLYTDYNKNGSSEPRLKTLDGLTSDYVFYFVTVLRQMQICALGNSYDAFNHDPWMDVVGFEDPDQVTNRDISRIVLYSYMFLNTAKGCLVEYATFRQYMRELPKNAPQKLNFREMRQGLIALGRHCVGSRFETDLYESATSELMANHSVQTGRNIYGVDSFSLTSVSGTTATLLQERASERWIQWLGLESDYHCSFSSTRNAEDVVAGEAASSDHHQKISRVTRKRPREPKSTNDILVAGQKLFGSSFEFRDLHQLRLCHEIYMADTPSVAVQAPPGYGKTELFHLPLIALASKGDVKYVSFLFVPYTVLLANCMIRLSRCGCLNVAPVRNFIEEGCDGVTDLYVGIYDDLASTNFTDRIAAWENIVECTFRTNNVKLGYLIVDEFHNFETEVYRQSQFGGITNLDFDAFEKAIFLSGTAPEAVADAALQRIGLTGLAKKSMDINELKRSEDLSRGLSSYPTRMFNLIKEKSEVPLGHVHKIWKKVESQPEEALKLLLALFEIEPESKAIVVASTTNEVEELACSWRKYFRVVWIHGKLGAAEKVSRTKEFVTDGSMRVLIGTKLVTEGIDIKQLMMVIMLDNRLNIIELIQGVGRLRDGGLCYLLSRKNSWAARNRKGELPPIKEGCITEQVREFYGLESKKGKKGQHVGCCGSRTDLSADTVELIERMDRLAEKQATASMSIVALPSSFQESNSSDRCRKYCSSDEDSDTCIHGSANASTNATTNSSTNATTTASTNVRTSATTTASINVRTSATTTESTNSSTNATTTASTNVRTSATTTASINVRTSATTTESTNSNTSATTTESTDSNTSATTTESTDSNTSATTTASTNSSTNATTTASTNSSTNATTTESTNASAKEDANKDGNAEDNRFHPVTDINKESYKRKGSQMVLLERKKLKAQFPNTSENMNVLQFLGFRSDEIKHLFLYGIDVYFCPEGVFTQYGLCKGCQKMFELCVCWAGQKVSYRRMAWEALAVERMLRNDEEYKEYLEDIEPYHGDPVGYLKYFSVKRGEIYSQIQRNYAWYLAITRRRETISVLDSTRGKQGSQVFRMSGRQIKELYYKVWSNLRESKTEVLQYFLNWDEKKCREEWEAKDDTVFVEALEKVGVFQRLRSMTSAGLQGPQYVKLQFSRHHRQLRSRYELSLGMHLRDQLALGVTPSKVPHWTAFLSMLIGLFCNKTFRQKLEYLLEQISEVWLLPHWLDLANVEVLAADNTRVPLYMLMVAVHKELDSDDVPDGRFDILLCRDSSREVGE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
177PhosphorylationAGDEEDRSITNEEPI
CCCHHHCCCCCCCCC		46.1919779198
242UbiquitinationNNGVAMWKWIKILYH
CCCEEHHHHHHHHHH		26.4217644757
245UbiquitinationVAMWKWIKILYHEVA
EEHHHHHHHHHHHHH		26.0817644757
258UbiquitinationVAQETALKDSYRITL
HHHHHHCCCCEEEEE		42.0117644757
260PhosphorylationQETALKDSYRITLVP
HHHHCCCCEEEEEEE		18.0927017623
261PhosphorylationETALKDSYRITLVPS
HHHCCCCEEEEEEEC		19.0327017623
364UbiquitinationKLRRDTNKMTAALKN
HHCCCCHHHHHHHHC		39.4623749301
430UbiquitinationQLYTDYNKNGSSEPR
EEECCCCCCCCCCCC		57.3617644757
526UbiquitinationQYMRELPKNAPQKLN
HHHHHCCCCCCCCCC		77.6423749301
582PhosphorylationRNIYGVDSFSLTSVS
CCEECCCCCEEEECC		17.8327214570
589PhosphorylationSFSLTSVSGTTATLL
CCEEEECCCCHHHHH		30.1427214570
799UbiquitinationTFRTNNVKLGYLIVD
EEECCCEEEEEEEEE		38.0117644757
834UbiquitinationLDFDAFEKAIFLSGT
CCHHHHHHHHHHCCC		40.0917644757
891UbiquitinationTRMFNLIKEKSEVPL
HHHHHHHHHCCCCCC		63.3617644757
893UbiquitinationMFNLIKEKSEVPLGH
HHHHHHHCCCCCCCH		47.0817644757
903UbiquitinationVPLGHVHKIWKKVES
CCCCHHHHHHHHHHC		49.5317644757
906UbiquitinationGHVHKIWKKVESQPE
CHHHHHHHHHHCCHH		50.8717644757
907UbiquitinationHVHKIWKKVESQPEE
HHHHHHHHHHCCHHH		35.9217644757
917UbiquitinationSQPEEALKLLLALFE
CCHHHHHHHHHHHHC		44.1017644757
1033PhosphorylationYLLSRKNSWAARNRK
EEEECCCCHHHHCCC		22.5627214570
1067UbiquitinationGLESKKGKKGQHVGC
CCCCCCCCCCCEECC		63.7117644757
1068UbiquitinationLESKKGKKGQHVGCC
CCCCCCCCCCEECCC		72.9117644757
1116PhosphorylationLPSSFQESNSSDRCR
CCCCCCCCCCCHHHH		31.0928889911
1118PhosphorylationSSFQESNSSDRCRKY
CCCCCCCCCHHHHHH		42.7828889911
1119PhosphorylationSFQESNSSDRCRKYC
CCCCCCCCHHHHHHC		33.0728889911
1159PhosphorylationTNATTTASTNVRTSA
CCCEECCCCEEECCE		20.5828889911
1164PhosphorylationTASTNVRTSATTTAS
CCCCEEECCEEEEEE		20.5927017623
1169PhosphorylationVRTSATTTASINVRT
EECCEEEEEEEEEEC		17.6627017623
1186PhosphorylationTTTESTNSSTNATTT
EECCCCCCCCCCEEE		38.3329688323
1187PhosphorylationTTESTNSSTNATTTA
ECCCCCCCCCCEEEE		27.9629688323
1188PhosphorylationTESTNSSTNATTTAS
CCCCCCCCCCEEEEE		28.7929688323
1191PhosphorylationTNSSTNATTTASTNV
CCCCCCCEEEEECCE		27.0929688323
1192PhosphorylationNSSTNATTTASTNVR
CCCCCCEEEEECCEE		20.2529688323
1193PhosphorylationSSTNATTTASTNVRT
CCCCCEEEEECCEEC		17.7929688323
1195PhosphorylationTNATTTASTNVRTSA
CCCEEEEECCEECCE		20.5828889911
1196PhosphorylationNATTTASTNVRTSAT
CCEEEEECCEECCEE		34.9629688323
1200PhosphorylationTASTNVRTSATTTAS
EEECCEECCEEEEEE		20.5927017623
1205PhosphorylationVRTSATTTASINVRT
EECCEEEEEEEEEEE		17.6627017623
1275PhosphorylationTNSSTNATTTESTNA
CCCCCCCCCCCCCCC		36.0027017623
1277PhosphorylationSSTNATTTESTNASA
CCCCCCCCCCCCCHH		24.4727017623
1280PhosphorylationNATTTESTNASAKED
CCCCCCCCCCHHCHH		28.6827017623
1313UbiquitinationNKESYKRKGSQMVLL
CHHHHHCCCCEEEEE		59.7817644757
1315PhosphorylationESYKRKGSQMVLLER
HHHHCCCCEEEEEEH		20.3825752575
1323UbiquitinationQMVLLERKKLKAQFP
EEEEEEHHHHHHHCC		53.7517644757
1326UbiquitinationLLERKKLKAQFPNTS
EEEHHHHHHHCCCCC		49.3617644757
1432UbiquitinationGDPVGYLKYFSVKRG
CCCCCEEEEEEEECC		35.4524961812
1437UbiquitinationYLKYFSVKRGEIYSQ
EEEEEEEECCCHHHH		54.1917644757
1471UbiquitinationVLDSTRGKQGSQVFR
EECCCCCCCCCEEEE		48.4723749301
1541PhosphorylationGVFQRLRSMTSAGLQ
CHHHHHHHCCCCCCC		30.8827017623
1552PhosphorylationAGLQGPQYVKLQFSR
CCCCCCCEEEEEECH		11.5927017623
1554UbiquitinationLQGPQYVKLQFSRHH
CCCCCEEEEEECHHH		31.4724961812
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of YRF12_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of YRF12_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of YRF12_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of YRF12_YEAST !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of YRF12_YEAST

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Related Literatures of Post-Translational Modification

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