KIN11_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KIN11_ARATH
• UniProt AC: P92958
• Protein Name: SNF1-related protein kinase catalytic subunit alpha KIN11
• Gene Name: KIN11
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 512
• Protein Description: Catalytic subunit of the probable trimeric SNF1-related protein kinase (SnRK) complex, which may play a role in a signal transduction cascade regulating gene expression and carbohydrate metabolism in higher plants. The SnRK complex may also be involved in the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase and in assimilation of nitrogen by phosphorylating nitrate reductase. In vitro, KIN11 exhibits kinase activity on sucrose phosphate synthase and the kinase activity is inhibited by PRL1. May be a subunit of a SCF ubiquitin ligase complex and thus be involved in proteasomal ubiquitination. Involved in innate antiviral defenses..
• Protein Sequence: MDHSSNRFGNNGVESILPNYKLGKTLGIGSFGKVKIAEHVVTGHKVAIKILNRRKIKNMEMEEKVRREIKILRLFMHPHIIRQYEVIETTSDIYVVMEYVKSGELFDYIVEKGRLQEDEARNFFQQIISGVEYCHRNMVVHRDLKPENLLLDSRCNIKIADFGLSNVMRDGHFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCGTLPFDDENIPNLFKKIKGGIYTLPSHLSSEARDLIPRMLIVDPVKRITIPEIRQHRWFQTHLPRYLAVSPPDTVEQAKKINEEIVQEVVNMGFDRNQVLESLRNRTQNDATVTYYLLLDNRFRVPSGYLESEFQETTDSGSNPMRTPEAGASPVGHWIPAHVDHYGLGARSQVPVDRKWALGLQSHAHPREIMNEVLKALQELNVCWKKIGHYNMKCRWVPGLADGQNTMVNNQLHFRDESSIIEDDCAMTSPTVIKFELQLYKAREEKYLLDIQRVNGPQFLFLDLCAAFLTELRVI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
165	Phosphorylation	KIADFGLSNVMRDGH EEECCCHHHHCCCCC	27.97	-
176	Phosphorylation	RDGHFLKTSCGSPNY CCCCEEECCCCCCCC	31.25	30291188
177	Phosphorylation	DGHFLKTSCGSPNYA CCCEEECCCCCCCCC	18.20	27532006
180	Phosphorylation	FLKTSCGSPNYAAPE EEECCCCCCCCCCCH	17.82	24601666
183	Phosphorylation	TSCGSPNYAAPEVIS CCCCCCCCCCCHHHC	13.92	23776212
190	Phosphorylation	YAAPEVISGKLYAGP CCCCHHHCCCCCCCC	34.74	19880383
360	Phosphorylation	SGSNPMRTPEAGASP CCCCCCCCCCCCCCC	21.16	27643528
366	Phosphorylation	RTPEAGASPVGHWIP CCCCCCCCCCCCCCC	21.14	27643528

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
176	T	Phosphorylation	Kinase	GRIK1	Q93V58	Uniprot
176	T	Phosphorylation	Kinase	GRIK2	Q5HZ38	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
176	T	Phosphorylation	Phosphorylated at Thr-176 by GRIK1/SNAK2 and GRIK2/SNAK1.	19339507
176	T	Phosphorylation	Phosphorylated at Thr-176 under submergence.	19339507

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KIN11_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DSP4_ARATH	SEX4	physical	12148529
SNF4_ARATH	SNF4	physical	17028154
KINB2_ARATH	AT4G16360	physical	11522840
SNF4_ARATH	SNF4	physical	10929106
KINB1_ARATH	AKINBETA1	physical	10417704
KINB2_ARATH	AT4G16360	physical	10417704
KING1_ARATH	KING1	physical	10417704
PRL1_ARATH	PRL1	physical	10220464
AAKG_YEAST	SNF4	physical	10220464
PSA7A_ARATH	PAD1	physical	11387208
SKP1A_ARATH	SKP1	physical	11387208
TOE2_ARATH	TOE2	physical	21798944
CDKF1_ARATH	CAK1AT	physical	21798944
TCP19_ARATH	AT5G51910	physical	21798944
GDU2_ARATH	GDU2	physical	22737156
PTR2_ARATH	PTR2	physical	22737156
CNG13_ARATH	CNGC13	physical	22737156
CAAT6_ARATH	CAT6	physical	22737156
GDU4_ARATH	GDU4	physical	22737156
CNG18_ARATH	CNGC18	physical	22737156
DNJ21_ARATH	ATERDJ2A	physical	22737156
ERDL4_ARATH	AT1G19450	physical	22737156
Y5410_ARATH	AT5G24100	physical	21423366
Y2899_ARATH	AT2G28990	physical	21423366
IDD8_ARATH	NUC	physical	25929516
SNF4_ARATH	SNF4	physical	8617787

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.