IDD8_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IDD8_ARATH
• UniProt AC: Q9FFH3
• Protein Name: Zinc finger protein NUTCRACKER
• Gene Name: NUC
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 466
• Subcellular Localization: Nucleus .
• Protein Description: Transcription factor that binds to the DNA sequence 5'-CTTTTGTCC-3'. Regulates photoperiodic flowering by modulating sugar transport and metabolism. Regulates SUS1 and SUS4..
• Protein Sequence: MTSEVLQTISSGSGFAQPQSSSTLDHDESLINPPLVKKKRNLPGNPDPEAEVIALSPTTLMATNRFLCEVCGKGFQRDQNLQLHRRGHNLPWKLKQRTSKEVRKRVYVCPEKTCVHHHSSRALGDLTGIKKHFCRKHGEKKWTCEKCAKRYAVQSDWKAHSKTCGTREYRCDCGTIFSRRDSFITHRAFCDALAEETAKINAVSHLNGLAAAGAPGSVNLNYQYLMGTFIPPLQPFVPQPQTNPNHHHQHFQPPTSSSLSLWMGQDIAPPQPQPDYDWVFGNAKAASACIDNNNTHDEQITQNANASLTTTTTLSAPSLFSSDQPQNANANSNVNMSATALLQKAAEIGATSTTTAATNDPSTFLQSFPLKSTDQTTSYDSGEKFFALFGSNNNIGLMSRSHDHQEIENARNDVTVASALDELQNYPWKRRRVDGGGEVGGGGQTRDFLGVGVQTLCHPSSINGWI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
56	Phosphorylation	EAEVIALSPTTLMAT HHHEEEECHHHHHHC		-
98	Phosphorylation	PWKLKQRTSKEVRKR CHHHCCCCCHHHHHH		25929516
178	Phosphorylation	CDCGTIFSRRDSFIT CCCCCCCCCCCCCHH		25929516
182	Phosphorylation	TIFSRRDSFITHRAF CCCCCCCCCHHHHHH		29654922
185	Phosphorylation	SRRDSFITHRAFCDA CCCCCCHHHHHHHHH		25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
98	T	Phosphorylation	Kinase	KIN10	Q38997	Uniprot
178	S	Phosphorylation	Kinase	KIN10	Q38997	Uniprot
182	S	Phosphorylation	Kinase	KIN10	Q38997	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
98	T	Phosphorylation	Inhibition of transcription factor activity by KIN10-mediated phosphorylation at Thr-98, Ser-178 and Ser-182 under sugar deprivation conditions, thus delaying flowering.	25929516
178	S	Phosphorylation	Inhibition of transcription factor activity by KIN10-mediated phosphorylation at Thr-98, Ser-178 and Ser-182 under sugar deprivation conditions, thus delaying flowering.	25929516
182	S	Phosphorylation	Inhibition of transcription factor activity by KIN10-mediated phosphorylation at Thr-98, Ser-178 and Ser-182 under sugar deprivation conditions, thus delaying flowering.	25929516

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IDD8_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KIN10_ARATH	KIN10	physical	25929516
KIN11_ARATH	KIN11	physical	25929516

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.