H2A2C_BOVIN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: H2A2C_BOVIN
• UniProt AC: A1A4R1
• Protein Name: Histone H2A type 2-C
• Gene Name: HIST2H2AC
• Organism: Bos taurus (Bovine).
• Sequence Length: 129
• Subcellular Localization: Nucleus. Chromosome.
• Protein Description: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling..
• Protein Sequence: MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYMAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKKTESHKAKSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSGRGKQGG ------CCCCCCCCH	36.88	1500420
2	Acetylation	------MSGRGKQGG ------CCCCCCCCH	36.88	-
4	Citrullination	----MSGRGKQGGKA ----CCCCCCCCHHH	41.66	-
4	Methylation	----MSGRGKQGGKA ----CCCCCCCCHHH	41.66	-
4	Citrullination	----MSGRGKQGGKA ----CCCCCCCCHHH	41.66	-
6	Acetylation	--MSGRGKQGGKARA --CCCCCCCCHHHHH	44.39	-
6	Other	--MSGRGKQGGKARA --CCCCCCCCHHHHH	44.39	-
10	Succinylation	GRGKQGGKARAKAKS CCCCCCHHHHHHHHH	41.34	-
10	Other	GRGKQGGKARAKAKS CCCCCCHHHHHHHHH	41.34	-
10	Lactoylation	GRGKQGGKARAKAKS CCCCCCHHHHHHHHH	41.34	-
37	Crotonylation	RVHRLLRKGNYAERV HHHHHHHCCCHHHHC	52.02	-
37	Other	RVHRLLRKGNYAERV HHHHHHHCCCHHHHC	52.02	-
37	N6-crotonyl-L-lysine	RVHRLLRKGNYAERV HHHHHHHCCCHHHHC	52.02	-
75	Other	GNAARDNKKTRIIPR CHHHHCCCCCCEEHH	60.87	-
76	Other	NAARDNKKTRIIPRH HHHHCCCCCCEEHHH	49.65	-
96	Other	RNDEELNKLLGKVTI CCHHHHHHHHCCEEE	58.68	-
96	Glutarylation	RNDEELNKLLGKVTI CCHHHHHHHHCCEEE	58.68	-
96	Succinylation	RNDEELNKLLGKVTI CCHHHHHHHHCCEEE	58.68	-
100	Glutarylation	ELNKLLGKVTIAQGG HHHHHHCCEEECCCC	35.85	-
105	Methylation	LGKVTIAQGGVLPNI HCCEEECCCCCCCCE	45.37	-
119	Glutarylation	IQAVLLPKKTESHKA EEEEECCCCCHHHCC	72.76	-
119	Crotonylation	IQAVLLPKKTESHKA EEEEECCCCCHHHCC	72.76	-
119	Other	IQAVLLPKKTESHKA EEEEECCCCCHHHCC	72.76	-
119	N6-crotonyl-L-lysine	IQAVLLPKKTESHKA EEEEECCCCCHHHCC	72.76	-
120	Glutarylation	QAVLLPKKTESHKAK EEEECCCCCHHHCCC	56.43	-
120	Crotonylation	QAVLLPKKTESHKAK EEEECCCCCHHHCCC	56.43	-
120	N6-crotonyl-L-lysine	QAVLLPKKTESHKAK EEEECCCCCHHHCCC	56.43	-
121	Phosphorylation	AVLLPKKTESHKAKS EEECCCCCHHHCCCC	49.17	-
123	Phosphorylation	LLPKKTESHKAKSK- ECCCCCHHHCCCCC-	35.20	-
125	N6-crotonyl-L-lysine	PKKTESHKAKSK--- CCCCHHHCCCCC---	67.78	-
125	Crotonylation	PKKTESHKAKSK--- CCCCHHHCCCCC---	67.78	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
2	S	Phosphorylation	Kinase	RPS6KA5	-	Uniprot
121	T	Phosphorylation	Kinase	DCAF1	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of H2A2C_BOVIN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of H2A2C_BOVIN !!

Protein-Protein Interaction

Oops, there are no PPI records of H2A2C_BOVIN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.