| UniProt ID | HIS1_YEAST | |
|---|---|---|
| UniProt AC | P00498 | |
| Protein Name | ATP phosphoribosyltransferase | |
| Gene Name | HIS1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 297 | |
| Subcellular Localization | Cytoplasm. | |
| Protein Description | Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of the enzymatic activity (By similarity).. | |
| Protein Sequence | MDLVNHLTDRLLFAIPKKGRLYSKSVSILNGADITFHRSQRLDIALSTSLPVALVFLPAADIPTFVGEGKCDLGITGVDQVRESNVDVDLAIDLQFGNCKLQVQVPVNGEYKKPEQLIGKTIVTSFVKLAEKYFADLEGTTVEKMTTRIKFVSGSVEASCALGIGDAIVDLVESGETMRAAGLVDIATVLSTSAYLIESKNPKSDKSLIATIKSRIEGVMTAQRFVSCIYNAPEDKLPELLKVTPGRRAPTISKIDDEGWVAVSSMIERKTKGVVLDELKRLGASDIMVFEISNCRV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MDLVNHLT -------CCHHHHHH | 8.96 | 22814378 | |
| 17 | Acetylation | RLLFAIPKKGRLYSK HHHHCCCCCCCEECE | 62.84 | 24489116 | |
| 24 | Acetylation | KKGRLYSKSVSILNG CCCCEECEEEEEECC | 41.12 | 22865919 | |
| 24 | Ubiquitination | KKGRLYSKSVSILNG CCCCEECEEEEEECC | 41.12 | 23749301 | |
| 112 | Acetylation | VPVNGEYKKPEQLIG ECCCCCCCCHHHHCC | 58.51 | 24489116 | |
| 113 | Acetylation | PVNGEYKKPEQLIGK CCCCCCCCHHHHCCH | 53.54 | 24489116 | |
| 128 | Acetylation | TIVTSFVKLAEKYFA HHHHHHHHHHHHHCC | 39.71 | 24489116 | |
| 128 | Ubiquitination | TIVTSFVKLAEKYFA HHHHHHHHHHHHHCC | 39.71 | 23749301 | |
| 132 | Ubiquitination | SFVKLAEKYFADLEG HHHHHHHHHCCCCCC | 39.81 | 23749301 | |
| 144 | Acetylation | LEGTTVEKMTTRIKF CCCCEEEEEECEEEE | 36.89 | 24489116 | |
| 193 | Phosphorylation | IATVLSTSAYLIESK HHHHHHHHHHHHHCC | 16.13 | 19779198 | |
| 195 | Phosphorylation | TVLSTSAYLIESKNP HHHHHHHHHHHCCCC | 14.15 | 19779198 | |
| 206 | Acetylation | SKNPKSDKSLIATIK CCCCCCCHHHHHHHH | 55.01 | 24489116 | |
| 236 | Acetylation | IYNAPEDKLPELLKV HHCCCHHHHCHHHHC | 65.37 | 24489116 | |
| 242 | Acetylation | DKLPELLKVTPGRRA HHHCHHHHCCCCCCC | 57.60 | 24489116 | |
| 270 | Ubiquitination | VSSMIERKTKGVVLD HHHHEECCCCCCHHH | 41.62 | 22817900 | |
| 272 | Ubiquitination | SMIERKTKGVVLDEL HHEECCCCCCHHHHH | 53.39 | 22817900 | |
| 280 | Ubiquitination | GVVLDELKRLGASDI CCHHHHHHHCCCCCE | 43.46 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HIS1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HIS1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HIS1_YEAST !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of HIS1_YEAST !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
