| UniProt ID | ALG11_YEAST | |
|---|---|---|
| UniProt AC | P53954 | |
| Protein Name | GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase | |
| Gene Name | ALG11 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 548 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Single-pass type II membrane protein . |
|
| Protein Description | Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum.. | |
| Protein Sequence | MGSAWTNYNFEEVKSHFGFKKYVVSSLVLVYGLIKVLTWIFRQWVYSSLNPFSKKSSLLNRAVASCGEKNVKVFGFFHPYCNAGGGGEKVLWKAVDITLRKDAKNVIVIYSGDFVNGENVTPENILNNVKAKFDYDLDSDRIFFISLKLRYLVDSSTWKHFTLIGQAIGSMILAFESIIQCPPDIWIDTMGYPFSYPIIARFLRRIPIVTYTHYPIMSKDMLNKLFKMPKKGIKVYGKILYWKVFMLIYQSIGSKIDIVITNSTWTNNHIKQIWQSNTCKIIYPPCSTEKLVDWKQKFGTAKGERLNQAIVLAQFRPEKRHKLIIESFATFLKNLPDSVSPIKLIMAGSTRSKQDENYVKSLQDWSENVLKIPKHLISFEKNLPFDKIEILLNKSTFGVNAMWNEHFGIAVVEYMASGLIPIVHASAGPLLDIVTPWDANGNIGKAPPQWELQKKYFAKLEDDGETTGFFFKEPSDPDYNTTKDPLRYPNLSDLFLQITKLDYDCLRVMGARNQQYSLYKFSDLKFDKDWENFVLNPICKLLEEEERG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 69 | Ubiquitination | AVASCGEKNVKVFGF HHHHCCCCCEEEEEE | 52.93 | 23749301 | |
| 224 | Acetylation | MSKDMLNKLFKMPKK CCHHHHHHHHCCCCC | 51.87 | 24489116 | |
| 262 | N-linked_Glycosylation | KIDIVITNSTWTNNH CCEEEEECCCCCCHH | 26.73 | - | |
| 319 | Acetylation | LAQFRPEKRHKLIIE HHHCCCHHHHHHHHH | 63.59 | 24489116 | |
| 381 | Ubiquitination | KHLISFEKNLPFDKI HHHHHHHCCCCHHHH | 62.87 | 17644757 | |
| 387 | Ubiquitination | EKNLPFDKIEILLNK HCCCCHHHHHHHHCC | 42.49 | 17644757 | |
| 393 | N-linked_Glycosylation | DKIEILLNKSTFGVN HHHHHHHCCCCCCCH | 32.55 | - | |
| 394 | Ubiquitination | KIEILLNKSTFGVNA HHHHHHCCCCCCCHH | 51.33 | 17644757 | |
| 480 | N-linked_Glycosylation | EPSDPDYNTTKDPLR CCCCCCCCCCCCCCC | 48.96 | - | |
| 490 | N-linked_Glycosylation | KDPLRYPNLSDLFLQ CCCCCCCCHHHHHHH | 43.15 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ALG11_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ALG11_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ALG11_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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