dbPTM

YD306_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	YD306_YEAST
UniProt AC	Q06640
Protein Name	F-box protein YDR306C
Gene Name	YDR306C
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	478
Subcellular Localization
Protein Description	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity)..
Protein Sequence	MANKSRPKKIKAPYRKYVAGEGFSSTRNDNKAKEFTITIPEDAELIETPQGSYYYDETNDTIVKLTRLSNEKKDKKGRKQSPSSSSTSSSKGEKNGKVIESEEARMHSVSVKMVLPWEIQHRIIHYLDIPEKEEKLNKTANGKKTTTGINMNYLLVCRNWYAMCLPKLYYAPALTSKNFNGFVDTIIINKKKNLGHYVFELNLSTILQSGRNSFVSKLLRRCCSNLTKFIAPQTSFGYAPLISLKSCHDLKFLDLGLVSETVKLKELFSAIKNFTKLTHLSFPRSSIDCQGFQDIQWPQNLRYLKLSGGITNEFVIDTKWPTTITTLEFSYCPQITELSIYSLLSQIGDNLKHLFFHYPMPSLAENSLDHVFTYCANLISLQLMVDYCSKWCFSEFMLSKLVEYDRPLKTLYLECSGSLGLASKIHPDDLTIAILESRLPCLKNICVSPKLGWNMKSDEVADLVVSLEDQDGSLYLNY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
169	Phosphorylation	AMCLPKLYYAPALTS HHHHHHHHCCHHHCC	12.05	19779198
175	Phosphorylation	LYYAPALTSKNFNGF HHCCHHHCCCCCCCC	39.50	19779198

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	YDR306C	Q06640	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of YD306_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of YD306_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDC53_YEAST	CDC53	physical	11805837
CAP_YEAST	SRV2	physical	11805837
SAHH_YEAST	SAH1	physical	11805837
STI1_YEAST	STI1	physical	11805837
PGM2_YEAST	PGM2	physical	11805837
SKP1_YEAST	SKP1	physical	11805837
MDHM_YEAST	MDH1	physical	11805837
LAG2_YEAST	LAG2	physical	19763088
YD306_YEAST	YDR306C	physical	14747994
TECR_YEAST	TSC13	genetic	27708008
RSP5_YEAST	RSP5	genetic	27708008
CDC4_YEAST	CDC4	genetic	27708008
ACT_YEAST	ACT1	genetic	27708008
SAD1_YEAST	SAD1	genetic	27708008
MED6_YEAST	MED6	genetic	27708008
EXO70_YEAST	EXO70	genetic	27708008
DPOD2_YEAST	POL31	genetic	27708008
DBP6_YEAST	DBP6	genetic	27708008
NOG2_YEAST	NOG2	genetic	27708008
NUF2_YEAST	NUF2	genetic	27708008
TYSY_YEAST	CDC21	genetic	27708008
MOT1_YEAST	MOT1	genetic	27708008
DIM1_YEAST	DIM1	genetic	27708008
SGF29_YEAST	SGF29	genetic	27708008
IMG2_YEAST	IMG2	genetic	27708008
SAN1_YEAST	SAN1	genetic	27708008
ODO2_YEAST	KGD2	genetic	27708008
ODPA_YEAST	PDA1	genetic	27708008
RCK1_YEAST	RCK1	genetic	27708008
CHO2_YEAST	CHO2	genetic	27708008
DAL81_YEAST	DAL81	genetic	27708008
SDHX_YEAST	YJL045W	genetic	27708008
MTC1_YEAST	MTC1	genetic	27708008
PET8_YEAST	PET8	genetic	27708008
DIA2_YEAST	DIA2	genetic	27708008
LIPA_YEAST	LIP5	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of YD306_YEAST

Related Literatures of Post-Translational Modification