PUS4_YEAST - dbPTM
PUS4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PUS4_YEAST
UniProt AC P48567
Protein Name tRNA pseudouridine synthase 4
Gene Name PUS4
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 403
Subcellular Localization Nucleus . Mitochondrion .
Protein Description Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. [PubMed: 9358157 Also catalyzes pseudouridylation of mRNAs with the consensus sequence 5'-GGUUCRA-3']
Protein Sequence MNGIFAIEKPSGITSNQFMLKLQHALTKSQVFSKEIQRATAERKQQYEKQTGKKASKRKLRKVSKVKMGHGGTLDPLASGVLVIGIGAGTKKLANYLSGTVKVYESEALFGVSTTSGDVEGEILSQNSVKHLNFDDLKTVEEKFVGQLKQTPPIYAALKMDGKPLHEYAREGKPLPRAIEPRQVTIYDLKVFSDSLKRDHDYPLLRPTTEEAVDTVKNLNANMLNDVLYFSKEYTEKHGLDSEVAKVEEPFPLSEQEEQEIQKEGDSYRAPKLHFKANVSSGTYIRSLVSDIGKSMRSSCYMVKLIRLQQQDWSLEKNNVFQLTDFTERDEKVWSKVLEKVLDEGATVDVIEELKKAEKEIPADVKECIVSSDQPGDEATAETIETANAEEHSNTLKRKIEQV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
28AcetylationKLQHALTKSQVFSKE
HHHHHHHHHHHHHHH		39.4824489116
96PhosphorylationGTKKLANYLSGTVKV
CHHHHHHHHHCCEEE		9.1727017623
100PhosphorylationLANYLSGTVKVYESE
HHHHHHCCEEEEECE		17.4927017623
163AcetylationAALKMDGKPLHEYAR
EEEEECCEEHHHHHH		39.8925381059
202PhosphorylationSLKRDHDYPLLRPTT
HCCCCCCCCCCCCCC		7.7428889911
208PhosphorylationDYPLLRPTTEEAVDT
CCCCCCCCCHHHHHH		40.1727214570
254PhosphorylationVEEPFPLSEQEEQEI
CCCCCCCCHHHHHHH		37.1622369663
281PhosphorylationHFKANVSSGTYIRSL
EEEEECCCCHHHHHH		30.7627214570
294UbiquitinationSLVSDIGKSMRSSCY
HHHHHHHHHHHHHHH		41.2224961812
324PhosphorylationKNNVFQLTDFTERDE
CCCEEECCCCCHHHH		20.4827017623
347PhosphorylationKVLDEGATVDVIEEL
HHHCCCCCHHHHHHH		28.2627017623
371PhosphorylationDVKECIVSSDQPGDE
CHHHHEECCCCCCCH		14.3228132839
372PhosphorylationVKECIVSSDQPGDEA
HHHHEECCCCCCCHH		29.3928152593
380PhosphorylationDQPGDEATAETIETA
CCCCCHHHHHHHHHC		23.9919779198
397AcetylationEEHSNTLKRKIEQV-
HHHHHHHHHHHHCC-		50.0025381059
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PUS4_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PUS4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PUS4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PUS4_YEASTPUS4physical
14759368
SYSM_YEASTDIA4physical
16554755
RRS1_YEASTRRS1physical
16554755
TRM1_YEASTTRM1genetic
19061648
TAN1_YEASTTAN1genetic
19061648
YBI1_YEASTYBL081Wgenetic
20093466
MAF1_YEASTMAF1genetic
20093466
TRM1_YEASTTRM1genetic
20093466
RLA4_YEASTRPP2Bgenetic
20093466
AGE1_YEASTAGE1genetic
20093466
PTP3_YEASTPTP3genetic
20093466
SHC1_YEASTSHC1genetic
20093466
VFA1_YEASTVFA1genetic
20093466
HXT10_YEASTHXT10genetic
20093466
TAN1_YEASTTAN1genetic
20093466
SDHA_YEASTSDH1genetic
20093466
COQ11_YEASTYLR290Cgenetic
20093466
PHO84_YEASTPHO84genetic
20093466
RAD14_YEASTRAD14genetic
20093466
ZRC1_YEASTZRC1genetic
20093466
VPS27_YEASTVPS27genetic
20093466
RU2A_YEASTLEA1genetic
20093466
PUS1_YEASTPUS1genetic
20093466
ATG5_YEASTATG5genetic
20093466
HSP7F_YEASTSSE1genetic
20093466
GPI7_YEASTLAS21genetic
27708008
YBI1_YEASTYBL081Wgenetic
27708008
MAF1_YEASTMAF1genetic
27708008
SWI5_YEASTSWI5genetic
27708008
TAN1_YEASTTAN1genetic
27708008
UBR2_YEASTUBR2genetic
27708008
ZRC1_YEASTZRC1genetic
27708008
VPS27_YEASTVPS27genetic
27708008
DIA2_YEASTDIA2genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
HSP7F_YEASTSSE1genetic
27708008
ATG5_YEASTATG5genetic
27708008
PUS1_YEASTPUS1genetic
27708008
RU2A_YEASTLEA1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PUS4_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-254, AND MASSSPECTROMETRY.

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