SHLB2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SHLB2_HUMAN
• UniProt AC: Q9NR46
• Protein Name: Endophilin-B2
• Gene Name: SH3GLB2
• Organism: Homo sapiens (Human).
• Sequence Length: 395
• Subcellular Localization: Cytoplasm .
• Protein Sequence: MDFNMKKLASDAGIFFTRAVQFTEEKFGQAEKTELDAHFENLLARADSTKNWTEKILRQTEVLLQPNPSARVEEFLYEKLDRKVPSRVTNGELLAQYMADAASELGPTTPYGKTLIKVAEAEKQLGAAERDFIHTASISFLTPLRNFLEGDWKTISKERRLLQNRRLDLDACKARLKKAKAAEAKATTVPDFQETRPRNYILSASASALWNDEVDKAEQELRVAQTEFDRQAEVTRLLLEGISSTHVNHLRCLHEFVKSQTTYYAQCYRHMLDLQKQLGRFPGTFVGTTEPASPPLSSTSPTTAAATMPVVPSVASLAPPGEASLCLEEVAPPASGTRKARVLYDYEAADSSELALLADELITVYSLPGMDPDWLIGERGNKKGKVPVTYLELLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDFNMKKL -------CCCCHHHH	13.82	22814378
6	Methylation	--MDFNMKKLASDAG --CCCCHHHHHHHHC	45.82	-
7	Methylation	-MDFNMKKLASDAGI -CCCCHHHHHHHHCC	38.22	-
7	Ubiquitination	-MDFNMKKLASDAGI -CCCCHHHHHHHHCC	38.22	-
10	Phosphorylation	FNMKKLASDAGIFFT CCHHHHHHHHCCEEH	38.13	27499020
17	Phosphorylation	SDAGIFFTRAVQFTE HHHCCEEHHHHHHCH	13.63	23186163
26 (in isoform 2)	Ubiquitination	-	48.87	21890473
26	Ubiquitination	AVQFTEEKFGQAEKT HHHHCHHHHCCCHHH	48.87	21890473
32	Ubiquitination	EKFGQAEKTELDAHF HHHCCCHHHHHHHHH	50.76	-
48	Phosphorylation	NLLARADSTKNWTEK HHHHHHHHCCCHHHH	40.05	27461979
49	Phosphorylation	LLARADSTKNWTEKI HHHHHHHCCCHHHHH	29.01	27461979
50	Ubiquitination	LARADSTKNWTEKIL HHHHHHCCCHHHHHH	55.21	-
53	Phosphorylation	ADSTKNWTEKILRQT HHHCCCHHHHHHHHH	36.47	27461979
55	Ubiquitination	STKNWTEKILRQTEV HCCCHHHHHHHHHHH	39.40	-
77	Phosphorylation	ARVEEFLYEKLDRKV HHHHHHHHHHHCCCC	19.15	21945579
77 (in isoform 2)	Phosphorylation	-	19.15	27642862
79	Ubiquitination	VEEFLYEKLDRKVPS HHHHHHHHHCCCCCC	41.97	21906983
79 (in isoform 1)	Ubiquitination	-	41.97	21890473
79 (in isoform 2)	Ubiquitination	-	41.97	21890473
97	Phosphorylation	NGELLAQYMADAASE CHHHHHHHHHHHHHH	6.67	29496907
108	Phosphorylation	AASELGPTTPYGKTL HHHHHCCCCCCCHHH	38.31	-
109	Phosphorylation	ASELGPTTPYGKTLI HHHHCCCCCCCHHHH	20.04	-
111	Phosphorylation	ELGPTTPYGKTLIKV HHCCCCCCCHHHHHH	29.21	29496907
117	Ubiquitination	PYGKTLIKVAEAEKQ CCCHHHHHHHHHHHH	38.21	-
123 (in isoform 1)	Ubiquitination	-	58.85	21890473
123 (in isoform 2)	Ubiquitination	-	58.85	21890473
123	Ubiquitination	IKVAEAEKQLGAAER HHHHHHHHHHCCCCH	58.85	21906983
137	Phosphorylation	RDFIHTASISFLTPL HHHCHHHHHHHCHHC	21.66	26270265
139	Phosphorylation	FIHTASISFLTPLRN HCHHHHHHHCHHCHH	16.23	26270265
142	Phosphorylation	TASISFLTPLRNFLE HHHHHHCHHCHHHHC	20.47	25159151
153 (in isoform 1)	Ubiquitination	-	40.49	21890473
153	Acetylation	NFLEGDWKTISKERR HHHCCCHHHHHHHHH	40.49	25953088
153 (in isoform 2)	Ubiquitination	-	40.49	21890473
153	Ubiquitination	NFLEGDWKTISKERR HHHCCCHHHHHHHHH	40.49	21906983
173	Ubiquitination	RLDLDACKARLKKAK CCCHHHHHHHHHHHH	37.96	-
178	Acetylation	ACKARLKKAKAAEAK HHHHHHHHHHHHHCC	60.76	7664671
180	Acetylation	KARLKKAKAAEAKAT HHHHHHHHHHHCCCC	57.94	7664683
185	Acetylation	KAKAAEAKATTVPDF HHHHHHCCCCCCCCH	37.46	7664695
185 (in isoform 1)	Ubiquitination	-	37.46	21890473
185	Ubiquitination	KAKAAEAKATTVPDF HHHHHHCCCCCCCCH	37.46	21906983
187	Phosphorylation	KAAEAKATTVPDFQE HHHHCCCCCCCCHHH	27.85	28348404
188	Phosphorylation	AAEAKATTVPDFQET HHHCCCCCCCCHHHC	34.60	26657352
195	Phosphorylation	TVPDFQETRPRNYIL CCCCHHHCCCCCEEE	34.88	21712546
198	Methylation	DFQETRPRNYILSAS CHHHCCCCCEEEEEE	45.34	-
203	Phosphorylation	RPRNYILSASASALW CCCCEEEEEEHHHHC	15.60	28464451
204 (in isoform 2)	Phosphorylation	-	12.98	27642862
205	Phosphorylation	RNYILSASASALWND CCEEEEEEHHHHCCH	21.27	25849741
207	Phosphorylation	YILSASASALWNDEV EEEEEEHHHHCCHHH	22.77	28464451
230	Methylation	VAQTEFDRQAEVTRL HHHHHHHHHHHHHHH	42.82	-
259	Phosphorylation	CLHEFVKSQTTYYAQ HHHHHHHHCHHHHHH	27.70	-
262	Phosphorylation	EFVKSQTTYYAQCYR HHHHHCHHHHHHHHH	13.60	-
263	Phosphorylation	FVKSQTTYYAQCYRH HHHHCHHHHHHHHHH	10.53	-
276	Ubiquitination	RHMLDLQKQLGRFPG HHHHHHHHHHCCCCC	55.58	21890473
276 (in isoform 1)	Ubiquitination	-	55.58	21890473
288	Phosphorylation	FPGTFVGTTEPASPP CCCCEEECCCCCCCC	23.76	28348404
289	Phosphorylation	PGTFVGTTEPASPPL CCCEEECCCCCCCCC	33.76	28348404
293	Phosphorylation	VGTTEPASPPLSSTS EECCCCCCCCCCCCC	37.45	26074081
297	Phosphorylation	EPASPPLSSTSPTTA CCCCCCCCCCCCCCC	37.03	26074081
298	Phosphorylation	PASPPLSSTSPTTAA CCCCCCCCCCCCCCH	40.36	26074081
299	Phosphorylation	ASPPLSSTSPTTAAA CCCCCCCCCCCCCHH	35.04	26074081
300	Phosphorylation	SPPLSSTSPTTAAAT CCCCCCCCCCCCHHC	23.38	26074081
302	Phosphorylation	PLSSTSPTTAAATMP CCCCCCCCCCHHCCC	28.91	26074081
303	Phosphorylation	LSSTSPTTAAATMPV CCCCCCCCCHHCCCC	20.06	26074081
307	Phosphorylation	SPTTAAATMPVVPSV CCCCCHHCCCCCCCH	19.79	26074081
313	Phosphorylation	ATMPVVPSVASLAPP HCCCCCCCHHHCCCC	20.78	26074081
316	O-linked_Glycosylation	PVVPSVASLAPPGEA CCCCCHHHCCCCCCC	23.94	OGP
316	Phosphorylation	PVVPSVASLAPPGEA CCCCCHHHCCCCCCC	23.94	26074081
363	Phosphorylation	LLADELITVYSLPGM HHHHHEEEHHCCCCC	26.47	30257219
365	Phosphorylation	ADELITVYSLPGMDP HHHEEEHHCCCCCCC	8.88	30257219
366	Phosphorylation	DELITVYSLPGMDPD HHEEEHHCCCCCCCC	24.61	30257219
390	Phosphorylation	KGKVPVTYLELLS-- CCCCCCEEEHHCC--	9.83	28102081
395	Phosphorylation	VTYLELLS------- CEEEHHCC-------	51.29	21712546

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SHLB2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SHLB2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SHLB2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CD158_HUMAN	CCDC158	physical	16189514
SH3K1_HUMAN	SH3KBP1	physical	11894096
SHLB1_HUMAN	SH3GLB1	physical	11161816
SHLB1_HUMAN	SH3GLB1	physical	20562859
UBA5_HUMAN	UBA5	physical	20562859
PGK1_HUMAN	PGK1	physical	20562859
FKBP4_HUMAN	FKBP4	physical	20562859
PA2G4_HUMAN	PA2G4	physical	20562859
KDM1A_HUMAN	KDM1A	physical	23455924
AASD1_HUMAN	AARSD1	physical	22863883
LZTL1_HUMAN	LZTFL1	physical	22863883
RUSD2_HUMAN	RPUSD2	physical	22863883
SH3G1_HUMAN	SH3GL1	physical	22863883
SHLB1_HUMAN	SH3GLB1	physical	22863883
TBCD_HUMAN	TBCD	physical	22863883
THG1_HUMAN	THG1L	physical	22863883
RHOA_HUMAN	RHOA	physical	16849557

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.