CD158_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CD158_HUMAN
• UniProt AC: Q5M9N0
• Protein Name: Coiled-coil domain-containing protein 158
• Gene Name: CCDC158
• Organism: Homo sapiens (Human).
• Sequence Length: 1113
• Protein Sequence: MESKAWESNNEDLLSSSGVTSNGGSSSSFFVSSIRGTIIENTSSAGTLTQVPFFPKYEVELDSPRKIIPSPGKEHFERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKMMLSHEGVLQEIRSILVDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQMEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKTEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVTNMEVALDKASLQFAECQDIIQRQEQESVRLKLQHTLDIKELQGPGYTSNSSLKPRLLQPASVTRSHSNVPSSQSTASFLSHHSTKANTLKEDPTRDLKQLLQELRSVINEEPAVSLSKTEEDGRTSLGALEDRVRDCITESSLRSDMCHRSNNSLRDSTEGSKSSETLSREPVTLHAGDREDPSGCFTFTSAASPSVKNSASRSFNSSPKKSPVHSLLTSSVEGSIGSTSQYRSAKPIHSSDSVKDSQSPPIETTGKTCRKLQNRLESLQTLVEDLQLKNQAMSSMIRNQEKRIQKVKDQEKMLLK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
63	Phosphorylation	KYEVELDSPRKIIPS CEEEECCCCCCCCCC	38.95	30622161
70	Phosphorylation	SPRKIIPSPGKEHFE CCCCCCCCCCHHHHH	35.56	-
111	Phosphorylation	QKFYLRQSVIDLQTK HHHHHHHHHHHHHHH	18.01	30622161
150	Phosphorylation	LRNQLQNTVHELEAA HHHHHHHHHHHHHHH	15.41	29978859
181	Phosphorylation	QLRKMMLSHEGVLQE HHHHHHHCCHHHHHH	11.12	24076635
220	Phosphorylation	LHFRSLGSAISKILR HHHHHHHHHHHHHHH	27.94	23403867
223	Phosphorylation	RSLGSAISKILRELD HHHHHHHHHHHHHHH	17.23	23403867
231	Phosphorylation	KILRELDTEISYLKG HHHHHHHHHHHHHCC	48.09	26270265
234	Phosphorylation	RELDTEISYLKGRIF HHHHHHHHHHCCCEE	20.41	25159151
235	Phosphorylation	ELDTEISYLKGRIFP HHHHHHHHHCCCEEE	20.35	25159151
408	Phosphorylation	KRLWDRDTGNSITID HCCCCCCCCCCCCHH	38.87	23403867
411	Phosphorylation	WDRDTGNSITIDHLR CCCCCCCCCCHHHHH	23.58	23403867
413	Phosphorylation	RDTGNSITIDHLRRE CCCCCCCCHHHHHHH	21.85	23403867
464	Phosphorylation	NESLEKVSSLTAQLE HHHHHHHHHHHHHHH	30.60	30622161
465	Phosphorylation	ESLEKVSSLTAQLES HHHHHHHHHHHHHHH	32.50	30622161
467	O-linked_Glycosylation	LEKVSSLTAQLESTK HHHHHHHHHHHHHHH	17.82	30379171
467	Phosphorylation	LEKVSSLTAQLESTK HHHHHHHHHHHHHHH	17.82	30622161
472	Phosphorylation	SLTAQLESTKEMLRK HHHHHHHHHHHHHHH	54.06	-
473	Phosphorylation	LTAQLESTKEMLRKV HHHHHHHHHHHHHHH	22.96	-
575	Phosphorylation	RQQIENMTQLVGQHG HHHHHHHHHHHHHCC	30.27	30622161
584	Phosphorylation	LVGQHGRTAGAMQVE HHHHCCCCCCCHHHH	33.75	30622161
664	Phosphorylation	QLLNEVKTSRSELNN HHHHHHHCCHHHHHH	34.25	26074081
665	Phosphorylation	LLNEVKTSRSELNNL HHHHHHCCHHHHHHH	28.26	26074081
667	Phosphorylation	NEVKTSRSELNNLSE HHHHCCHHHHHHHHH	46.32	26074081
673	Phosphorylation	RSELNNLSEEYEVLK HHHHHHHHHHHHHHH	30.42	26074081
676	Phosphorylation	LNNLSEEYEVLKRNF HHHHHHHHHHHHHHC	13.79	26074081
706	Phosphorylation	MQLKSAQSELEQTRN HHHHHHHHHHHHHHH	43.81	30622161
717	Phosphorylation	QTRNTLKSMEGSDGH HHHHHHHHCCCCHHH	25.77	22210691
721	Phosphorylation	TLKSMEGSDGHAMKV HHHHCCCCHHHHHHH	27.41	22210691
772	Phosphorylation	HFLKEEKSKLSQELS HHHHHHHHHHHHHHH	41.95	30622161
775	Phosphorylation	KEEKSKLSQELSTVA HHHHHHHHHHHHHHH	25.91	30622161
779	Phosphorylation	SKLSQELSTVATEKN HHHHHHHHHHHHHHH	21.78	30622161
780	Phosphorylation	KLSQELSTVATEKNK HHHHHHHHHHHHHHH	27.12	30622161
868	Phosphorylation	PRLLQPASVTRSHSN CCCCCCCCCCCCCCC	30.61	25690035
870	Phosphorylation	LLQPASVTRSHSNVP CCCCCCCCCCCCCCC	24.78	25690035
878	Phosphorylation	RSHSNVPSSQSTASF CCCCCCCCCHHHHHH	36.41	-
879	Phosphorylation	SHSNVPSSQSTASFL CCCCCCCCHHHHHHH	23.29	-
922	Phosphorylation	INEEPAVSLSKTEED HCCCCCCCCCCCCCC	29.09	30622161
924	Phosphorylation	EEPAVSLSKTEEDGR CCCCCCCCCCCCCCC	29.99	30622161
926	Phosphorylation	PAVSLSKTEEDGRTS CCCCCCCCCCCCCCC	41.03	22210691
932	Phosphorylation	KTEEDGRTSLGALED CCCCCCCCCHHHHHH	33.56	22210691
933	Phosphorylation	TEEDGRTSLGALEDR CCCCCCCCHHHHHHH	24.36	22210691
958	Phosphorylation	RSDMCHRSNNSLRDS HHHHCCCCCCCCCCC	19.39	23927012
961	Phosphorylation	MCHRSNNSLRDSTEG HCCCCCCCCCCCCCC	29.09	23927012
1075	Phosphorylation	KLQNRLESLQTLVED HHHHHHHHHHHHHHH	30.30	30622161
1078	Phosphorylation	NRLESLQTLVEDLQL HHHHHHHHHHHHHHH	37.76	30622161
1091	Phosphorylation	QLKNQAMSSMIRNQE HHHHHHHHHHHHHHH	21.55	-
1092	Phosphorylation	LKNQAMSSMIRNQEK HHHHHHHHHHHHHHH	12.73	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CD158_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CD158_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CD158_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MYCB2_HUMAN	MYCBP2	physical	26186194
SG2A1_HUMAN	SCGB2A1	physical	26186194
SG2A1_HUMAN	SCGB2A1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.