FAAA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FAAA_HUMAN
• UniProt AC: P16930
• Protein Name: Fumarylacetoacetase
• Gene Name: FAH
• Organism: Homo sapiens (Human).
• Sequence Length: 419
• Protein Sequence: MSFIPVAEDSDFPIHNLPYGVFSTRGDPRPRIGVAIGDQILDLSIIKHLFTGPVLSKHQDVFNQPTLNSFMGLGQAAWKEARVFLQNLLSVSQARLRDDTELRKCAFISQASATMHLPATIGDYTDFYSSRQHATNVGIMFRDKENALMPNWLHLPVGYHGRASSVVVSGTPIRRPMGQMKPDDSKPPVYGACKLLDMELEMAFFVGPGNRLGEPIPISKAHEHIFGMVLMNDWSARDIQKWEYVPLGPFLGKSFGTTVSPWVVPMDALMPFAVPNPKQDPRPLPYLCHDEPYTFDINLSVNLKGEGMSQAATICKSNFKYMYWTMLQQLTHHSVNGCNLRPGDLLASGTISGPEPENFGSMLELSWKGTKPIDLGNGQTRKFLLDGDEVIITGYCQGDGYRIGFGQCAGKVLPALLPS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSFIPVAED ------CCCCCCCCC	31.70	24043423
2	Acetylation	------MSFIPVAED ------CCCCCCCCC	31.70	25944712
10	Phosphorylation	FIPVAEDSDFPIHNL CCCCCCCCCCCCCCC	32.43	24043423
19	Phosphorylation	FPIHNLPYGVFSTRG CCCCCCCCCEEECCC	29.14	24043423
23	Phosphorylation	NLPYGVFSTRGDPRP CCCCCEEECCCCCCC	18.13	24043423
24	Phosphorylation	LPYGVFSTRGDPRPR CCCCEEECCCCCCCC	27.49	24043423
44	Phosphorylation	GDQILDLSIIKHLFT CCCHHHHHHHHHHHH	23.18	24719451
57	Acetylation	FTGPVLSKHQDVFNQ HHCCCHHCCHHHHCC	40.92	25953088
79	Acetylation	GLGQAAWKEARVFLQ HHHHHHHHHHHHHHH	36.45	25953088
90	Phosphorylation	VFLQNLLSVSQARLR HHHHHHHHHHHHHCC	23.92	28857561
92	Phosphorylation	LQNLLSVSQARLRDD HHHHHHHHHHHCCCC	18.10	28857561
128	Phosphorylation	IGDYTDFYSSRQHAT CCCCHHHHHCCCCCC	14.46	-
144	Ubiquitination	VGIMFRDKENALMPN EEEEEECCCCCCCCC	48.92	-
164	Phosphorylation	VGYHGRASSVVVSGT CCCCCCCCEEEEECC	23.46	28857561
165	Phosphorylation	GYHGRASSVVVSGTP CCCCCCCEEEEECCC	20.25	28857561
219	Phosphorylation	LGEPIPISKAHEHIF CCCCEECHHHHHHHH	20.59	21406692
241	Ubiquitination	WSARDIQKWEYVPLG CCHHHHCCCEEEECC	42.18	21890473
241	Ubiquitination	WSARDIQKWEYVPLG CCHHHHCCCEEEECC	42.18	21890473
241	Acetylation	WSARDIQKWEYVPLG CCHHHHCCCEEEECC	42.18	20167786
244	Phosphorylation	RDIQKWEYVPLGPFL HHHCCCEEEECCCCC	13.27	-
308	Sulfoxidation	VNLKGEGMSQAATIC EEECCCCCCHHHHHH	2.03	30846556
309	Phosphorylation	NLKGEGMSQAATICK EECCCCCCHHHHHHH	27.76	28857561
313	Phosphorylation	EGMSQAATICKSNFK CCCCHHHHHHHHHHH	29.89	29255136
370	Phosphorylation	LELSWKGTKPIDLGN EEEEECCCCCEECCC	29.89	-
371	Ubiquitination	ELSWKGTKPIDLGNG EEEECCCCCEECCCC	48.95	-
395	Phosphorylation	DEVIITGYCQGDGYR CEEEEEEECCCCCCE	3.49	7550234
411	Ubiquitination	GFGQCAGKVLPALLP CCCCCCCCCHHHHCC	23.29	-
419	Phosphorylation	VLPALLPS------- CHHHHCCC-------	53.47	28102081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FAAA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FAAA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FAAA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KRA59_HUMAN	KRTAP5-9	physical	25416956
ITF2_HUMAN	TCF4	physical	25416956
SRTD1_HUMAN	SERTAD1	physical	25416956
ATL4_HUMAN	ADAMTSL4	physical	25416956
KR108_HUMAN	KRTAP10-8	physical	25416956
PGM1_HUMAN	PGM1	physical	26344197
DHSO_HUMAN	SORD	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 276700: Tyrosinemia 1 (TYRSN1)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.