FRS3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FRS3_HUMAN
• UniProt AC: O43559
• Protein Name: Fibroblast growth factor receptor substrate 3
• Gene Name: FRS3
• Organism: Homo sapiens (Human).
• Sequence Length: 492
• Subcellular Localization: Membrane; Lipid-anchor.
• Protein Description: Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2..
• Protein Sequence: MGSCCSCLNRDSVPDNHPTKFKVTNVDDEGVELGSGVMELTQSELVLHLHRREAVRWPYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCSRAEEIFNLLQDLMQCNSINVMEEPVIITRNSHPAELDLPRAPQPPNALGYTVSSFSNGCPGEGPRFSAPRRLSTSSLRHPSLGEESTHALIAPDEQSHTYVNTPASEDDHRRGRHCLQPLPEGQAPFLPQARGPDQRDPQVFLQPGQVKFVLGPTPARRHMVKCQGLCPSLHDPPHHNNNNEAPSECPAQPKCTYENVTGGLWRGAGWRLSPEEPGWNGLAHRRAALLHYENLPPLPPVWESQAQQLGGEAGDDGDSRDGLTPSSNGFPDGEEDETPLQKPTSTRAAIRSHGSFPVPLTRRRGSPRVFNFDFRRPGPEPPRQLNYIQVELKGWGGDRPKGPQNPSSPQAPMPTTHPARSSDSYAVIDLKKTVAMSNLQRALPRDDGTARKTRHNSTDLPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGSCCSCLN ------CCCCCCCCC	29.41	9660748
73	Phosphorylation	GYDSNLFSFESGRRC CCCCCCEEECCCCCC	31.13	-
76	Phosphorylation	SNLFSFESGRRCQTG CCCEEECCCCCCCCC	35.27	-
159	Phosphorylation	PGEGPRFSAPRRLST CCCCCCCCCCCCCCC	38.35	24719451
165	Phosphorylation	FSAPRRLSTSSLRHP CCCCCCCCCCCCCCC	25.16	23927012
166	Phosphorylation	SAPRRLSTSSLRHPS CCCCCCCCCCCCCCC	27.25	23927012
167	Phosphorylation	APRRLSTSSLRHPSL CCCCCCCCCCCCCCC	24.81	23927012
168	Phosphorylation	PRRLSTSSLRHPSLG CCCCCCCCCCCCCCC	29.52	23927012
349	Phosphorylation	EAGDDGDSRDGLTPS CCCCCCCCCCCCCCC	37.49	-
417	Phosphorylation	EPPRQLNYIQVELKG CCCCCCCEEEEEECC	11.00	11432792
437	Phosphorylation	PKGPQNPSSPQAPMP CCCCCCCCCCCCCCC	63.30	25307156
438	Phosphorylation	KGPQNPSSPQAPMPT CCCCCCCCCCCCCCC	23.45	25307156
455	Phosphorylation	PARSSDSYAVIDLKK CCCCCCCEEEEEHHH	15.18	25884760
463	Phosphorylation	AVIDLKKTVAMSNLQ EEEEHHHHHHHHHHH	16.35	22468782
467	Phosphorylation	LKKTVAMSNLQRALP HHHHHHHHHHHHHCC	25.34	22468782

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FRS3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FRS3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FRS3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SH3K1_HUMAN	SH3KBP1	physical	23279575
CD2AP_HUMAN	CD2AP	physical	23279575
CBL_HUMAN	CBL	physical	23279575
ERBB2_HUMAN	ERBB2	physical	23279575
ATL4_HUMAN	ADAMTSL4	physical	25416956
SPERT_HUMAN	SPERT	physical	25416956
RFX6_HUMAN	RFX6	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956
MATK_HUMAN	MATK	physical	25814554
NUMB_HUMAN	NUMB	physical	25814554
P55G_HUMAN	PIK3R3	physical	25814554
VASP_HUMAN	VASP	physical	25814554
SH2B1_HUMAN	SH2B1	physical	25814554
SOCS4_HUMAN	SOCS4	physical	25814554
FRS3_HUMAN	FRS3	physical	25814554
DDX5_HUMAN	DDX5	physical	25814554
GRB14_HUMAN	GRB14	physical	25814554
SOCS6_HUMAN	SOCS6	physical	25814554
TENS1_HUMAN	TNS1	physical	25814554
HCK_HUMAN	HCK	physical	25814554

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.