| UniProt ID | PLPP6_HUMAN | |
|---|---|---|
| UniProt AC | Q8IY26 | |
| Protein Name | Phospholipid phosphatase 6 {ECO:0000312|HGNC:HGNC:23682} | |
| Gene Name | PLPP6 {ECO:0000312|HGNC:HGNC:23682} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 295 | |
| Subcellular Localization |
Membrane Multi-pass membrane protein . |
|
| Protein Description | Phosphatase that dephosphorylates presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may be indirectly involved in innate immunity. PSDP is a bioactive lipid that rapidly remodels to presqualene monophosphate PSMP upon cell activation. Displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid.. | |
| Protein Sequence | MPSPRRSMEGRPLGVSASSSSSSPGSPAHGGGGGGSRFEFQSLLSSRATAVDPTCARLRASESPVHRRGSFPLAAAGPSQSPAPPLPEEDRMDLNPSFLGIALRSLLAIDLWLSKKLGVCAGESSSWGSVRPLMKLLEISGHGIPWLLGTLYCLCRSDSWAGREVLMNLLFALLLDLLLVALIKGLVRRRRPAHNQMDMFVTLSVDKYSFPSGHATRAALMSRFILNHLVLAIPLRVLVVLWAFVLGLSRVMLGRHNVTDVAFGFFLGYMQYSIVDYCWLSPHNAPVLFLLWSQR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Phosphorylation | -MPSPRRSMEGRPLG -CCCCCCCCCCCCCC | 27174698 | ||
| 16 | Phosphorylation | EGRPLGVSASSSSSS CCCCCCCCCCCCCCC | 29978859 | ||
| 18 | Phosphorylation | RPLGVSASSSSSSPG CCCCCCCCCCCCCCC | 29978859 | ||
| 19 | Phosphorylation | PLGVSASSSSSSPGS CCCCCCCCCCCCCCC | 29978859 | ||
| 20 | Phosphorylation | LGVSASSSSSSPGSP CCCCCCCCCCCCCCC | 30206219 | ||
| 21 | Phosphorylation | GVSASSSSSSPGSPA CCCCCCCCCCCCCCC | 29978859 | ||
| 22 | Phosphorylation | VSASSSSSSPGSPAH CCCCCCCCCCCCCCC | 30206219 | ||
| 23 | Phosphorylation | SASSSSSSPGSPAHG CCCCCCCCCCCCCCC | 30206219 | ||
| 26 | Phosphorylation | SSSSSPGSPAHGGGG CCCCCCCCCCCCCCC | 23401153 | ||
| 36 | Phosphorylation | HGGGGGGSRFEFQSL CCCCCCCCHHHHHHH | 30206219 | ||
| 42 | Phosphorylation | GSRFEFQSLLSSRAT CCHHHHHHHHHHCCC | 28857561 | ||
| 45 | Phosphorylation | FEFQSLLSSRATAVD HHHHHHHHHCCCCCC | 24719451 | ||
| 46 | Phosphorylation | EFQSLLSSRATAVDP HHHHHHHHCCCCCCH | 21712546 | ||
| 61 | Phosphorylation | TCARLRASESPVHRR HHHHHHCCCCCCCCC | 30266825 | ||
| 63 | Phosphorylation | ARLRASESPVHRRGS HHHHCCCCCCCCCCC | 30266825 | ||
| 70 | Phosphorylation | SPVHRRGSFPLAAAG CCCCCCCCCCCCCCC | 23401153 | ||
| 79 | Phosphorylation | PLAAAGPSQSPAPPL CCCCCCCCCCCCCCC | 23927012 | ||
| 81 | Phosphorylation | AAAGPSQSPAPPLPE CCCCCCCCCCCCCCH | 21815630 | ||
| 97 | Phosphorylation | DRMDLNPSFLGIALR HCCCCCHHHHHHHHH | 28450419 | ||
| 114 | Phosphorylation | LAIDLWLSKKLGVCA HHHHHHHHHHHCCCC | 27732954 | ||
| 124 | Phosphorylation | LGVCAGESSSWGSVR HCCCCCCCCCHHCHH | 27251275 | ||
| 129 | Phosphorylation | GESSSWGSVRPLMKL CCCCCHHCHHHHHHH | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PLPP6_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PLPP6_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PLPP6_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of PLPP6_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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