IL32_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IL32_HUMAN
• UniProt AC: P24001
• Protein Name: Interleukin-32
• Gene Name: IL32
• Organism: Homo sapiens (Human).
• Sequence Length: 234
• Subcellular Localization: Secreted .
• Protein Description: Cytokine that may play a role in innate and adaptive immune responses. It induces various cytokines such as TNFA/TNF-alpha and IL8. It activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK..
• Protein Sequence: MCFPKVLSDDMKKLKARMVMLLPTSAQGLGAWVSACDTEDTVGHLGPWRDKDPALWCQLCLSSQHQAIERFYDKMQNAESGRGQVMSSLAELEDDFKEGYLETVAAYYEEQHPELTPLLEKERDGLRCRGNRSPVPDVEDPATEEPGESFCDKVMRWFQAMLQRLQTWWHGVLAWVKEKVVALVHAVQALWKQFQSFCCSLSELFMSSFQSYGAPRGDKEELTPQKCSEPQSSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Ubiquitination	KVLSDDMKKLKARMV CCCCHHHHHHHHHHH	63.05	22505724
12	Ubiquitination	KVLSDDMKKLKARMV CCCCHHHHHHHHHHH	63.05	-
13	Ubiquitination	VLSDDMKKLKARMVM CCCHHHHHHHHHHHH	48.89	-
13	Ubiquitination	VLSDDMKKLKARMVM CCCHHHHHHHHHHHH	48.89	22505724
18	Ubiquitination	MKKLKARMVMLLPTS HHHHHHHHHHHCCCC	2.19	29901268
28 (in isoform 1)	Ubiquitination	-	26.29	20972266
28 (in isoform 2)	Ubiquitination	-	26.29	-
28	Ubiquitination	LLPTSAQGLGAWVSA HCCCCCCCCCHHHHC	26.29	23000965
35	Ubiquitination	GLGAWVSACDTEDTV CCCHHHHCCCCCCCC	5.89	-
50	Phosphorylation	GHLGPWRDKDPALWC CCCCCCCCCCHHHHH	56.70	-
51	Ubiquitination	HLGPWRDKDPALWCQ CCCCCCCCCHHHHHH	57.97	-
55	Ubiquitination	WRDKDPALWCQLCLS CCCCCHHHHHHHHHH	5.98	23503661
66	Ubiquitination	LCLSSQHQAIERFYD HHHHCHHHHHHHHHH	36.08	23503661
67	Ubiquitination	CLSSQHQAIERFYDK HHHCHHHHHHHHHHH	11.95	-
74	Ubiquitination	AIERFYDKMQNAESG HHHHHHHHHHHCCCC	30.89	23000965
75	Ubiquitination	IERFYDKMQNAESGR HHHHHHHHHHCCCCC	3.20	23503661
75 (in isoform 2)	Ubiquitination	-	3.20	-
87	Phosphorylation	SGRGQVMSSLAELED CCCHHHHHHHHHHHH	24.28	28122231
88	Phosphorylation	GRGQVMSSLAELEDD CCHHHHHHHHHHHHH	17.32	28122231
97	Ubiquitination	AELEDDFKEGYLETV HHHHHHHHHCHHHHH	58.17	-
100	Phosphorylation	EDDFKEGYLETVAAY HHHHHHCHHHHHHHH	11.49	27642862
103	Phosphorylation	FKEGYLETVAAYYEE HHHCHHHHHHHHHHH	16.92	28796482
107	Phosphorylation	YLETVAAYYEEQHPE HHHHHHHHHHHHCCC	11.15	28796482
108	Phosphorylation	LETVAAYYEEQHPEL HHHHHHHHHHHCCCC	14.30	28796482
116	Phosphorylation	EEQHPELTPLLEKER HHHCCCCHHHHHHHH	15.38	28796482
121	Ubiquitination	ELTPLLEKERDGLRC CCHHHHHHHHCCCCC	59.00	23503661
133	Phosphorylation	LRCRGNRSPVPDVED CCCCCCCCCCCCCCC	33.96	23401153
143	Phosphorylation	PDVEDPATEEPGESF CCCCCCCCCCCCHHH	46.39	28111955
149	Phosphorylation	ATEEPGESFCDKVMR CCCCCCHHHHHHHHH	36.77	28111955
153	Ubiquitination	PGESFCDKVMRWFQA CCHHHHHHHHHHHHH	38.83	-
219	Ubiquitination	YGAPRGDKEELTPQK HCCCCCCHHHCCCCC	56.78	-
223	Phosphorylation	RGDKEELTPQKCSEP CCCHHHCCCCCCCCC	27.27	24719451
226	Ubiquitination	KEELTPQKCSEPQSS HHHCCCCCCCCCCCC	40.71	-
234	Ubiquitination	CSEPQSSK------- CCCCCCCC-------	70.39	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IL32_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IL32_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IL32_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IL32_HUMAN	IL32	physical	25178676
ZBT16_HUMAN	ZBTB16	physical	25178676
FOG2_HUMAN	ZFPM2	physical	25178676
C1QB_HUMAN	C1QB	physical	25178676
NQO2_HUMAN	NQO2	physical	25178676
IMA6_HUMAN	KPNA5	physical	25178676
HSP7C_HUMAN	HSPA8	physical	25178676
STPAP_HUMAN	TUT1	physical	25178676
NECD_HUMAN	NDN	physical	25178676
RU17_HUMAN	SNRNP70	physical	25178676
RL4_HUMAN	RPL4	physical	25178676
KPCD_HUMAN	PRKCD	physical	25178676
KPCE_HUMAN	PRKCE	physical	25178676
BCL6_HUMAN	BCL6	physical	25245533
VHL_HUMAN	VHL	physical	29050245

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.