CDO1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CDO1_HUMAN
• UniProt AC: Q16878
• Protein Name: Cysteine dioxygenase type 1
• Gene Name: CDO1
• Organism: Homo sapiens (Human).
• Sequence Length: 200
• Protein Description: Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range..
• Protein Sequence: MEQTEVLKPRTLADLIRILHQLFAGDEVNVEEVQAIMEAYESDPTEWAMYAKFDQYRYTRNLVDQGNGKFNLMILCWGEGHGSSIHDHTNSHCFLKMLQGNLKETLFAWPDKKSNEMVKKSERVLRENQCAYINDSIGLHRVENISHTEPAVSLHLYSPPFDTCHAFDQRTGHKNKVTMTFHSKFGIRTPNATSGSLENN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MEQTEVLKPRT ----CCCCCCCCHHH	18.11	-
8	Ubiquitination	MEQTEVLKPRTLADL CCCCCCCCHHHHHHH	37.31	-
59	Phosphorylation	KFDQYRYTRNLVDQG CCHHHEECCCEEECC	12.23	22817900
171	Phosphorylation	CHAFDQRTGHKNKVT CEEECCCCCCCCEEE	37.70	22210691
189	Phosphorylation	HSKFGIRTPNATSGS EHHCCCCCCCCCCCC	20.97	21406692
193	Phosphorylation	GIRTPNATSGSLENN CCCCCCCCCCCCCCC	40.02	21406692
194	Phosphorylation	IRTPNATSGSLENN- CCCCCCCCCCCCCC-	24.79	21406692
196	Phosphorylation	TPNATSGSLENN--- CCCCCCCCCCCC---	32.07	21406692

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CDO1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CDO1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CDO1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CP17A_HUMAN	CYP17A1	physical	21988832
LRC58_HUMAN	LRRC58	physical	28514442
MTMR4_HUMAN	MTMR4	physical	28514442
ODB2_HUMAN	DBT	physical	28514442
RERE_HUMAN	RERE	physical	28514442
TOPB1_HUMAN	TOPBP1	physical	28514442
TRXR1_HUMAN	TXNRD1	physical	28514442
KCC1A_HUMAN	CAMK1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00151: L-Cysteine

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-59, AND MASSSPECTROMETRY.
PubMed: 15302935