| UniProt ID | CP17A_HUMAN | |
|---|---|---|
| UniProt AC | P05093 | |
| Protein Name | Steroid 17-alpha-hydroxylase/17,20 lyase | |
| Gene Name | CYP17A1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 508 | |
| Subcellular Localization | Membrane . | |
| Protein Description | Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.. | |
| Protein Sequence | MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQAEGST | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 60 | Phosphorylation | FFKLQKKYGPIYSVR HHHHHHHHCCEEEEE | 34.86 | 20049867 | |
| 65 | Phosphorylation | KKYGPIYSVRMGTKT HHHCCEEEEECCCCE | 12.17 | 23401153 | |
| 70 | Phosphorylation | IYSVRMGTKTTVIVG EEEEECCCCEEEEEC | 18.84 | 21712546 | |
| 72 | Phosphorylation | SVRMGTKTTVIVGHH EEECCCCEEEEECCH | 26.57 | 21712546 | |
| 258 | Phosphorylation | KEKFRSDSITNMLDT HHHHCHHHHHHHHHH | 32.34 | 22817900 | |
| 326 | Acetylation | LHNPQVKKKLYEEID HCCHHHHHHHHHHHH | 49.51 | 16713412 | |
| 327 | Acetylation | HNPQVKKKLYEEIDQ CCHHHHHHHHHHHHH | 51.05 | 16713412 | |
| 329 | Phosphorylation | PQVKKKLYEEIDQNV HHHHHHHHHHHHHHC | 22.01 | 22817900 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 258 | S | Phosphorylation | Kinase | PRKACA | P17612 | GPS |
| 258 | S | Phosphorylation | Kinase | PKA-FAMILY | - | GPS |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CP17A_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CP17A_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| HS90B_HUMAN | HSP90AB1 | physical | 21988832 | |
| RIP_HUMAN | RPAIN | physical | 21988832 | |
| TIGD7_HUMAN | TIGD7 | physical | 21988832 |
| Kegg Disease | |
|---|---|
| H00216 | Congenital adrenal hyperplasia (CAH) |
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenita |
| OMIM Disease | |
| 202110 | Adrenal hyperplasia 5 (AH5) |
| Kegg Drug | |
| D00351 | Ketoconazole (JP16/USP); Nizoral (TN); Xolegel (TN) |
| D00420 | Mitotane (JAN/USP/INN); Lysodren (TN) |
| D03781 | Liarozole fumarate (USAN); Liazal (TN) |
| D03784 | Liarozole hydrochloride (USAN) |
| D09701 | Abiraterone acetate (JAN/USAN); Zytiga (TN) |
| D10125 | Galeterone (USAN) |
| D10146 | Orteronel (USAN) |
| DrugBank | |
| DB05812 | Abiraterone |
| DB01424 | Aminophenazone |
| DB01234 | Dexamethasone |
| DB01233 | Metoclopramide |
| DB00396 | Progesterone |
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