UniProt ID | RWDD3_HUMAN | |
---|---|---|
UniProt AC | Q9Y3V2 | |
Protein Name | RWD domain-containing protein 3 | |
Gene Name | RWDD3 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 267 | |
Subcellular Localization | Nucleus . Cytoplasm . Colocalizes with UBC9/UBE2I in nuclear spots. | |
Protein Description | Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1. Isoform 1 and isoform 2 positively regulate the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha (NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity. Isoform 1 and isoform 2 negatively regulate the hypoxia-inducible factor-1 alpha (HIF1A) signaling pathway by increasing the sumoylation of HIF1A, promoting its stabilization, transcriptional activity and the expression of its target gene VEGFA during hypoxia. Isoform 2 promotes the sumoylation and transcriptional activity of the glucocorticoid receptor NR3C1 and enhances the interaction of SUMO1 and NR3C1 with UBE2I/UBC9. Has no effect on ubiquitination.. | |
Protein Sequence | MAEPVQEELSVLAAIFCRPHEWEVLSRSETDGTVFRIHTKAEGFMDVDIPLELVFHLPVNYPSCLPGISINSEQLTRAQCVTVKENLLEQAESLLSEPMVHELVLWIQQNLRHILSQPETGSGSEKCTFSTSTTMDDGLWITLLHLDHMRAKTKYVKIVEKWASDLRLTGRLMFMGKIILILLQGDRNNLKEYLILQKTSKVDVDSSGKKCKEKMISVLFETKVQTEHKRFLAFEVKEYSALDELQKEFETAGLKKLFSEFVLALVK | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
157 | Ubiquitination | RAKTKYVKIVEKWAS CCCCCHHHHHHHHHH | 37.63 | - | |
161 | Ubiquitination | KYVKIVEKWASDLRL CHHHHHHHHHHCCHH | 36.85 | - | |
209 | Acetylation | VDVDSSGKKCKEKMI CCCCCCCCCCHHHHH | 57.87 | 25953088 | |
232 | Ubiquitination | QTEHKRFLAFEVKEY CCCCCEEEEEEEHHH | 6.57 | - |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RWDD3_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RWDD3_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RWDD3_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
SUMO1_HUMAN | SUMO1 | physical | 17956732 | |
UBC9_HUMAN | UBE2I | physical | 17956732 | |
IKBA_HUMAN | NFKBIA | physical | 17956732 | |
HIF1A_HUMAN | HIF1A | physical | 17956732 | |
VHL_HUMAN | VHL | physical | 25500545 | |
HIF1A_HUMAN | HIF1A | physical | 25500545 |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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