RWDD3_HUMAN - dbPTM
RWDD3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RWDD3_HUMAN
UniProt AC Q9Y3V2
Protein Name RWD domain-containing protein 3
Gene Name RWDD3
Organism Homo sapiens (Human).
Sequence Length 267
Subcellular Localization Nucleus . Cytoplasm . Colocalizes with UBC9/UBE2I in nuclear spots.
Protein Description Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1. Isoform 1 and isoform 2 positively regulate the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha (NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity. Isoform 1 and isoform 2 negatively regulate the hypoxia-inducible factor-1 alpha (HIF1A) signaling pathway by increasing the sumoylation of HIF1A, promoting its stabilization, transcriptional activity and the expression of its target gene VEGFA during hypoxia. Isoform 2 promotes the sumoylation and transcriptional activity of the glucocorticoid receptor NR3C1 and enhances the interaction of SUMO1 and NR3C1 with UBE2I/UBC9. Has no effect on ubiquitination..
Protein Sequence MAEPVQEELSVLAAIFCRPHEWEVLSRSETDGTVFRIHTKAEGFMDVDIPLELVFHLPVNYPSCLPGISINSEQLTRAQCVTVKENLLEQAESLLSEPMVHELVLWIQQNLRHILSQPETGSGSEKCTFSTSTTMDDGLWITLLHLDHMRAKTKYVKIVEKWASDLRLTGRLMFMGKIILILLQGDRNNLKEYLILQKTSKVDVDSSGKKCKEKMISVLFETKVQTEHKRFLAFEVKEYSALDELQKEFETAGLKKLFSEFVLALVK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
157UbiquitinationRAKTKYVKIVEKWAS
CCCCCHHHHHHHHHH
37.63-
161UbiquitinationKYVKIVEKWASDLRL
CHHHHHHHHHHCCHH
36.85-
209AcetylationVDVDSSGKKCKEKMI
CCCCCCCCCCHHHHH
57.8725953088
232UbiquitinationQTEHKRFLAFEVKEY
CCCCCEEEEEEEHHH
6.57-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RWDD3_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RWDD3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RWDD3_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SUMO1_HUMANSUMO1physical
17956732
UBC9_HUMANUBE2Iphysical
17956732
IKBA_HUMANNFKBIAphysical
17956732
HIF1A_HUMANHIF1Aphysical
17956732
VHL_HUMANVHLphysical
25500545
HIF1A_HUMANHIF1Aphysical
25500545

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RWDD3_HUMAN

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Related Literatures of Post-Translational Modification

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