CAN7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAN7_HUMAN
• UniProt AC: Q9Y6W3
• Protein Name: Calpain-7
• Gene Name: CAPN7
• Organism: Homo sapiens (Human).
• Sequence Length: 813
• Subcellular Localization: Nucleus.
• Protein Description: Calcium-regulated non-lysosomal thiol-protease..
• Protein Sequence: MDATALERDAVQFARLAVQRDHEGRYSEAVFYYKEAAQALIYAEMAGSSLENIQEKITEYLERVQALHSAVQSKSADPLKSKHQLDLERAHFLVTQAFDEDEKENVEDAIELYTEAVDLCLKTSYETADKVLQNKLKQLARQALDRAEALSEPLTKPVGKISSTSVKPKPPPVRAHFPLGANPFLERPQSFISPQSCDAQGQRYTAEEIEVLRTTSKINGIEYVPFMNVDLRERFAYPMPFCDRWGKLPLSPKQKTTFSKWVRPEDLTNNPTMIYTVSSFSIKQTIVSDCSFVASLAISAAYERRFNKKLITGIIYPQNKDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELLCSYSNNKSELWVSLIEKAYMKVMGGYDFPGSNSNIDLHALTGWIPERIAMHSDSQTFSKDNSFRMLYQRFHKGDVLITASTGMMTEAEGEKWGLVPTHAYAVLDIREFKGLRFIQLKNPWSHLRWKGRYSENDVKNWTPELQKYLNFDPRTAQKIDNGIFWISWDDLCQYYDVIYLSWNPGLFKESTCIHSTWDAKQGPVKDAYSLANNPQYKLEVQCPQGGAAVWVLLSRHITDKDDFANNREFITMVVYKTDGKKVYYPADPPPYIDGIRINSPHYLTKIKLTTPGTHTFTLVVSQYEKQNTIHYTVRVYSACSFTFSKIPSPYTLSKRINGKWSGQSAGGCGNFQETHKNNPIYQFHIEKTGPLLIELRGPRQYSVGFEVVTVSTLGDPGPHGFLRKSSGDYRCGFCYLELENIPSGIFNIIPSTFLPKQEGPFFLDFNSIIPIKITQLQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDATALER -------CCCHHHHH	7.74	22814378
33	Phosphorylation	YSEAVFYYKEAAQAL CEEEEEEHHHHHHHH	7.29	24719451
42	Phosphorylation	EAAQALIYAEMAGSS HHHHHHHHHHHCCCC	9.43	-
74	Ubiquitination	LHSAVQSKSADPLKS HHHHHHCCCCCCCCC	32.35	21890473
75	Phosphorylation	HSAVQSKSADPLKSK HHHHHCCCCCCCCCH	43.05	24719451
80	Ubiquitination	SKSADPLKSKHQLDL CCCCCCCCCHHHHHH	63.95	-
82	Ubiquitination	SADPLKSKHQLDLER CCCCCCCHHHHHHHH	33.51	-
95	Phosphorylation	ERAHFLVTQAFDEDE HHHHHHHEECCCHHH	19.14	22817900
124	Phosphorylation	VDLCLKTSYETADKV HHHHHHCCHHHHHHH	21.27	28796482
125	Phosphorylation	DLCLKTSYETADKVL HHHHHCCHHHHHHHH	23.64	28796482
127	Phosphorylation	CLKTSYETADKVLQN HHHCCHHHHHHHHHH	31.74	28796482
130	Ubiquitination	TSYETADKVLQNKLK CCHHHHHHHHHHHHH	42.24	21890473
135	Ubiquitination	ADKVLQNKLKQLARQ HHHHHHHHHHHHHHH	44.06	-
137	Ubiquitination	KVLQNKLKQLARQAL HHHHHHHHHHHHHHH	44.89	-
156	Acetylation	ALSEPLTKPVGKISS HHCCCCCCCCCCCCC	45.44	23236377
156	Ubiquitination	ALSEPLTKPVGKISS HHCCCCCCCCCCCCC	45.44	21890473
162	O-linked_Glycosylation	TKPVGKISSTSVKPK CCCCCCCCCCCCCCC	30.92	29351928
162	Phosphorylation	TKPVGKISSTSVKPK CCCCCCCCCCCCCCC	30.92	23312004
163	Phosphorylation	KPVGKISSTSVKPKP CCCCCCCCCCCCCCC	28.33	26270265
164	Phosphorylation	PVGKISSTSVKPKPP CCCCCCCCCCCCCCC	30.65	28857561
165	Phosphorylation	VGKISSTSVKPKPPP CCCCCCCCCCCCCCC	30.05	28857561
167	Ubiquitination	KISSTSVKPKPPPVR CCCCCCCCCCCCCCC	47.28	-
190	Phosphorylation	PFLERPQSFISPQSC CCCCCCCHHCCCCCC	27.51	20873877
193	Phosphorylation	ERPQSFISPQSCDAQ CCCCHHCCCCCCCCC	18.18	20873877
214	Phosphorylation	EEIEVLRTTSKINGI HHHHHHEECCCCCCE	31.12	24719451
216	Phosphorylation	IEVLRTTSKINGIEY HHHHEECCCCCCEEE	30.81	24719451
217	Ubiquitination	EVLRTTSKINGIEYV HHHEECCCCCCEEEE	37.79	-
247	Ubiquitination	PFCDRWGKLPLSPKQ CCCCCCCCCCCCCCC	39.72	21890473
251	Phosphorylation	RWGKLPLSPKQKTTF CCCCCCCCCCCCCCC	28.28	23312004
253	Ubiquitination	GKLPLSPKQKTTFSK CCCCCCCCCCCCCCC	62.14	-
279	Phosphorylation	TMIYTVSSFSIKQTI EEEEEEEECCCCEEE	20.76	24719451
281	Phosphorylation	IYTVSSFSIKQTIVS EEEEEECCCCEEECC	30.72	24719451
309	Ubiquitination	YERRFNKKLITGIIY HHHHHCCCEEEEEEC	46.34	-
320	Ubiquitination	GIIYPQNKDGEPEYN EEECCCCCCCCCCCC	62.96	-
331	Ubiquitination	PEYNPCGKYMVKLHL CCCCCCCCEEEEEEC	36.57	-
335	Ubiquitination	PCGKYMVKLHLNGVP CCCCEEEEEECCCCC	17.41	-
344	Ubiquitination	HLNGVPRKVIIDDQL ECCCCCCEEEECCCC	31.54	-
356	Ubiquitination	DQLPVDHKGELLCSY CCCCCCCCCCEEEEE	50.01	-
362	Phosphorylation	HKGELLCSYSNNKSE CCCCEEEEECCCCCH	31.40	23401153
363	Phosphorylation	KGELLCSYSNNKSEL CCCEEEEECCCCCHH	17.89	20873877
364	Phosphorylation	GELLCSYSNNKSELW CCEEEEECCCCCHHH	20.03	20873877
373	Phosphorylation	NKSELWVSLIEKAYM CCCHHHHHHHHHHHH	16.43	24719451
412	Phosphorylation	PERIAMHSDSQTFSK CHHEECCCCCCCCCC	26.35	-
414	Phosphorylation	RIAMHSDSQTFSKDN HEECCCCCCCCCCCC	33.85	-
416	Phosphorylation	AMHSDSQTFSKDNSF ECCCCCCCCCCCCHH	33.55	-
419	Ubiquitination	SDSQTFSKDNSFRML CCCCCCCCCCHHHHH	57.65	21890473
477	Ubiquitination	GLRFIQLKNPWSHLR CCEEEEECCCCHHHC	44.59	-
489	Phosphorylation	HLRWKGRYSENDVKN HHCCCCCCCCCHHHH	29.07	-
490	Phosphorylation	LRWKGRYSENDVKNW HCCCCCCCCCHHHHC	28.67	-
495	Ubiquitination	RYSENDVKNWTPELQ CCCCCHHHHCCHHHH	50.02	21890473
498	Phosphorylation	ENDVKNWTPELQKYL CCHHHHCCHHHHHHH	19.11	29396449
503	Ubiquitination	NWTPELQKYLNFDPR HCCHHHHHHHCCCHH	65.41	21890473
556	Ubiquitination	IHSTWDAKQGPVKDA EEEECCCCCCCCCCH	54.00	-
561	Ubiquitination	DAKQGPVKDAYSLAN CCCCCCCCCHHHHHC	39.51	-
596	Ubiquitination	LSRHITDKDDFANNR EECCCCCHHHCCCCC	51.01	21890473
617	Ubiquitination	VYKTDGKKVYYPADP EEEECCCEEEECCCC	40.78	-
619	Phosphorylation	KTDGKKVYYPADPPP EECCCEEEECCCCCC	16.77	22817900
620	Phosphorylation	TDGKKVYYPADPPPY ECCCEEEECCCCCCC	8.57	22817900
627	Phosphorylation	YPADPPPYIDGIRIN ECCCCCCCCCCEEEC	19.88	22817900
635	Phosphorylation	IDGIRINSPHYLTKI CCCEEECCCCEEEEE	15.64	-
641	Ubiquitination	NSPHYLTKIKLTTPG CCCCEEEEEEEECCC	34.94	-
659	Phosphorylation	FTLVVSQYEKQNTIH EEEEEEEECCCCCEE	20.00	-
667	Phosphorylation	EKQNTIHYTVRVYSA CCCCCEEEEEEEEEE	11.77	-
695	Ubiquitination	LSKRINGKWSGQSAG ECCCCCCEECCCCCC	33.43	-
697	Phosphorylation	KRINGKWSGQSAGGC CCCCCEECCCCCCCC	30.36	-
700	Phosphorylation	NGKWSGQSAGGCGNF CCEECCCCCCCCCCC	32.19	-
712	Ubiquitination	GNFQETHKNNPIYQF CCCHHHHCCCCEEEE	66.88	-
723	Ubiquitination	IYQFHIEKTGPLLIE EEEEEEEECCCEEEE	59.17	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAN7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAN7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAN7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ANCHR_HUMAN	ZFYVE19	physical	25416956
UBL7_HUMAN	UBL7	physical	25416956
ZBTB9_HUMAN	ZBTB9	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.