| UniProt ID | CNTF_HUMAN | |
|---|---|---|
| UniProt AC | P26441 | |
| Protein Name | Ciliary neurotrophic factor | |
| Gene Name | CNTF | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 200 | |
| Subcellular Localization | Cytoplasm. | |
| Protein Description | CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.. | |
| Protein Sequence | MAFTEHSPLTPHRRDLCSRSIWLARKIRSDLTALTESYVKHQGLNKNINLDSADGMPVASTDQWSELTEAERLQENLQAYRTFHVLLARLLEDQQVHFTPTEGDFHQAIHTLLLQVAAFAYQIEELMILLEYKIPRNEADGMPINVGDGGLFEKKLWGLKVLQELSQWTVRSIHDLRFISSHQTGIPARGSHYIANNKKM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 166 | Phosphorylation | LKVLQELSQWTVRSI HHHHHHHHHCHHCCH | 23.95 | 28348404 | |
| 169 | Phosphorylation | LQELSQWTVRSIHDL HHHHHHCHHCCHHHH | 9.82 | 24719451 | |
| 172 | Phosphorylation | LSQWTVRSIHDLRFI HHHCHHCCHHHHHHH | 21.68 | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CNTF_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CNTF_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CNTF_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| STK16_HUMAN | STK16 | physical | 17353931 | |
| EIF3E_HUMAN | EIF3E | physical | 17353931 | |
| IL6RA_HUMAN | IL6R | physical | 1281789 | |
| CNTF_HUMAN | CNTF | physical | 7796798 | |
| TRIP6_HUMAN | TRIP6 | physical | 25416956 | |
| K1C40_HUMAN | KRT40 | physical | 25416956 | |
| CORO7_HUMAN | CORO7 | physical | 28514442 | |
| RAE1_HUMAN | CHM | physical | 28514442 | |
| RBM12_HUMAN | RBM12 | physical | 28514442 | |
| FEM1B_HUMAN | FEM1B | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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