CO4A6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CO4A6_HUMAN
• UniProt AC: Q14031
• Protein Name: Collagen alpha-6(IV) chain
• Gene Name: COL4A6
• Organism: Homo sapiens (Human).
• Sequence Length: 1691
• Subcellular Localization: Secreted, extracellular space, extracellular matrix, basement membrane.
• Protein Description: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen..
• Protein Sequence: MLINKLWLLLVTLCLTEELAAAGEKSYGKPCGGQDCSGSCQCFPEKGARGRPGPIGIQGPTGPQGFTGSTGLSGLKGERGFPGLLGPYGPKGDKGPMGVPGFLGINGIPGHPGQPGPRGPPGLDGCNGTQGAVGFPGPDGYPGLLGPPGLPGQKGSKGDPVLAPGSFKGMKGDPGLPGLDGITGPQGAPGFPGAVGPAGPPGLQGPPGPPGPLGPDGNMGLGFQGEKGVKGDVGLPGPAGPPPSTGELEFMGFPKGKKGSKGEPGPKGFPGISGPPGFPGLGTTGEKGEKGEKGIPGLPGPRGPMGSEGVQGPPGQQGKKGTLGFPGLNGFQGIEGQKGDIGLPGPDVFIDIDGAVISGNPGDPGVPGLPGLKGDEGIQGLRGPSGVPGLPALSGVPGALGPQGFPGLKGDQGNPGRTTIGAAGLPGRDGLPGPPGPPGPPSPEFETETLHNKESGFPGLRGEQGPKGNLGLKGIKGDSGFCACDGGVPNTGPPGEPGPPGPWGLIGLPGLKGARGDRGSGGAQGPAGAPGLVGPLGPSGPKGKKGEPILSTIQGMPGDRGDSGSQGFRGVIGEPGKDGVPGLPGLPGLPGDGGQGFPGEKGLPGLPGEKGHPGPPGLPGNGLPGLPGPRGLPGDKGKDGLPGQQGLPGSKGITLPCIIPGSYGPSGFPGTPGFPGPKGSRGLPGTPGQPGSSGSKGEPGSPGLVHLPELPGFPGPRGEKGLPGFPGLPGKDGLPGMIGSPGLPGSKGATGDIFGAENGAPGEQGLQGLTGHKGFLGDSGLPGLKGVHGKPGLLGPKGERGSPGTPGQVGQPGTPGSSGPYGIKGKSGLPGAPGFPGISGHPGKKGTRGKKGPPGSIVKKGLPGLKGLPGNPGLVGLKGSPGSPGVAGLPALSGPKGEKGSVGFVGFPGIPGLPGIPGTRGLKGIPGSTGKMGPSGRAGTPGEKGDRGNPGPVGIPSPRRPMSNLWLKGDKGSQGSAGSNGFPGPRGDKGEAGRPGPPGLPGAPGLPGIIKGVSGKPGPPGFMGIRGLPGLKGSSGITGFPGMPGESGSQGIRGSPGLPGASGLPGLKGDNGQTVEISGSPGPKGQPGESGFKGTKGRDGLIGNIGFPGNKGEDGKVGVSGDVGLPGAPGFPGVAGMRGEPGLPGSSGHQGAIGPLGSPGLIGPKGFPGFPGLHGLNGLPGTKGTHGTPGPSITGVPGPAGLPGPKGEKGYPGIGIGAPGKPGLRGQKGDRGFPGLQGPAGLPGAPGISLPSLIAGQPGDPGRPGLDGERGRPGPAGPPGPPGPSSNQGDTGDPGFPGIPGPKGPKGDQGIPGFSGLPGELGLKGMRGEPGFMGTPGKVGPPGDPGFPGMKGKAGPRGSSGLQGDPGQTPTAEAVQVPPGPLGLPGIDGIPGLTGDPGAQGPVGLQGSKGLPGIPGKDGPSGLPGPPGALGDPGLPGLQGPPGFEGAPGQQGPFGMPGMPGQSMRVGYTLVKHSQSEQVPPCPIGMSQLWVGYSLLFVEGQEKAHNQDLGFAGSCLPRFSTMPFIYCNINEVCHYARRNDKSYWLSTTAPIPMMPVSQTQIPQYISRCSVCEAPSQAIAVHSQDITIPQCPLGWRSLWIGYSFLMHTAAGAEGGGQSLVSPGSCLEDFRATPFIECSGARGTCHYFANKYSFWLTTVEERQQFGELPVSETLKAGQLHTRVSRCQVCMKSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
127	N-linked_Glycosylation	PPGLDGCNGTQGAVG CCCCCCCCCCCCCCC	63.17	UniProtKB CARBOHYD
260	Phosphorylation	FPKGKKGSKGEPGPK CCCCCCCCCCCCCCC	46.50	22210691
283	Phosphorylation	PGFPGLGTTGEKGEK CCCCCCCCCCCCCCC	36.35	22210691
284	Phosphorylation	GFPGLGTTGEKGEKG CCCCCCCCCCCCCCC	41.36	22210691
473	Acetylation	PKGNLGLKGIKGDSG CCCCCCCCCCCCCCC	57.71	7491921
686	Phosphorylation	GSRGLPGTPGQPGSS CCCCCCCCCCCCCCC	23.47	-
802	Phosphorylation	GPKGERGSPGTPGQV CCCCCCCCCCCCCCC	26.78	-
805	Phosphorylation	GERGSPGTPGQVGQP CCCCCCCCCCCCCCC	27.85	-
821	Phosphorylation	TPGSSGPYGIKGKSG CCCCCCCCCCCCCCC	34.70	29759185
844	Ubiquitination	GISGHPGKKGTRGKK CCCCCCCCCCCCCCC	53.10	-
845	Ubiquitination	ISGHPGKKGTRGKKG CCCCCCCCCCCCCCC	72.00	-
944	Ubiquitination	RAGTPGEKGDRGNPG CCCCCCCCCCCCCCC	72.52	-
963	Phosphorylation	PSPRRPMSNLWLKGD CCCCCCCCCCEECCC	31.30	-
979	Phosphorylation	GSQGSAGSNGFPGPR CCCCCCCCCCCCCCC	33.23	-
1014	Phosphorylation	PGIIKGVSGKPGPPG CCCCCCCCCCCCCCC	50.17	22210691
1047	Phosphorylation	FPGMPGESGSQGIRG CCCCCCCCCCCCCCC	50.05	-
1049	Phosphorylation	GMPGESGSQGIRGSP CCCCCCCCCCCCCCC	34.22	-
1055	Phosphorylation	GSQGIRGSPGLPGAS CCCCCCCCCCCCCCC	13.12	22210691
1074	Phosphorylation	LKGDNGQTVEISGSP CCCCCCCEEEECCCC	22.85	22210691
1078	Phosphorylation	NGQTVEISGSPGPKG CCCEEEECCCCCCCC	21.51	25627689
1080	Phosphorylation	QTVEISGSPGPKGQP CEEEECCCCCCCCCC	21.64	22210691
1335	Phosphorylation	GEPGFMGTPGKVGPP CCCCCCCCCCCCCCC	19.65	22798277
1394	Phosphorylation	IDGIPGLTGDPGAQG CCCCCCCCCCCCCCC	45.51	28787133
1463	Phosphorylation	MPGMPGQSMRVGYTL CCCCCCCCCCCEEEE	17.93	24961811
1656	O-linked_Glycosylation	KYSFWLTTVEERQQF CEEEEEEEHHHHHHH	24.61	29351928

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CO4A6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CO4A6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CO4A6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
SUMF1_HUMAN	SUMF1	physical	26344197

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.