| UniProt ID | HYAS1_HUMAN | |
|---|---|---|
| UniProt AC | Q92839 | |
| Protein Name | Hyaluronan synthase 1 | |
| Gene Name | HAS1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 578 | |
| Subcellular Localization |
Membrane Multi-pass membrane protein . |
|
| Protein Description | Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate (By similarity).. | |
| Protein Sequence | MRQQDAPKPTPAACRCSGLARRVLTIAFALLILGLMTWAYAAGVPLASDRYGLLAFGLYGAFLSAHLVAQSLFAYLEHRRVAAAARGPLDAATARSVALTISAYQEDPAYLRQCLASARALLYPRARLRVLMVVDGNRAEDLYMVDMFREVFADEDPATYVWDGNYHQPWEPAAAGAVGAGAYREVEAEDPGRLAVEALVRTRRCVCVAQRWGGKREVMYTAFKALGDSVDYVQVCDSDTRLDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYFHCVSCISGPLGLYRNNLLQQFLEAWYNQKFLGTHCTFGDDRHLTNRMLSMGYATKYTSRSRCYSETPSSFLRWLSQQTRWSKSYFREWLYNALWWHRHHAWMTYEAVVSGLFPFFVAATVLRLFYAGRPWALLWVLLCVQGVALAKAAFAAWLRGCLRMVLLSLYAPLYMCGLLPAKFLALVTMNQSGWGTSGRRKLAANYVPLLPLALWALLLLGGLVRSVAHEARADWSGPSRAAEAYHLAAGAGAYVGYWVAMLTLYWVGVRRLCRRRTGGYRVQV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 281 | Phosphorylation | DSWVSFLSSLRYWVA HHHHHHHHHHHHHHH | 30301811 | ||
| 282 | Phosphorylation | SWVSFLSSLRYWVAF HHHHHHHHHHHHHHH | 25954137 | ||
| 351 | Phosphorylation | NRMLSMGYATKYTSR HHHHHHCCCCCCCCC | 22817900 | ||
| 355 | Phosphorylation | SMGYATKYTSRSRCY HHCCCCCCCCCCCCC | 22817900 | ||
| 367 | Phosphorylation | RCYSETPSSFLRWLS CCCCCCCHHHHHHHH | - | ||
| 368 | Phosphorylation | CYSETPSSFLRWLSQ CCCCCCHHHHHHHHH | 24719451 | ||
| 424 | Phosphorylation | ATVLRLFYAGRPWAL HHHHHHHHCCCHHHH | - | ||
| 520 | Phosphorylation | LLGGLVRSVAHEARA HHHHHHHHHHHHHCC | 27499020 | ||
| 571 | Phosphorylation | RRLCRRRTGGYRVQV HHHHCHHCCCCCCCC | 22817900 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HYAS1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HYAS1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HYAS1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of HYAS1_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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