SAT2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SAT2_HUMAN
• UniProt AC: Q96F10
• Protein Name: Diamine acetyltransferase 2
• Gene Name: SAT2
• Organism: Homo sapiens (Human).
• Sequence Length: 170
• Subcellular Localization: Cytoplasm. Intracellular organelles.
• Protein Description: Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine > spermidine = spermine >> N(1)acetylspermine = putrescine..
• Protein Sequence: MASVRIREAKEGDCGDILRLIRELAEFEKLSDQVKISEEALRADGFGDNPFYHCLVAEILPAPGKLLGPCVVGYGIYYFIYSTWKGRTIYLEDIYVMPEYRGQGIGSKIIKKVAEVALDKGCSQFRLAVLDWNQRAMDLYKALGAQDLTEAEGWHFFCFQGEATRKLAGK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASVRIREAK -----CCCCCCEECC	15.61	24719451
10	Ubiquitination	SVRIREAKEGDCGDI CCCCEECCCCCHHHH	58.43	-
29	Acetylation	RELAEFEKLSDQVKI HHHHHHHHHHHHCCC	59.62	19608861
29	Ubiquitination	RELAEFEKLSDQVKI HHHHHHHHHHHHCCC	59.62	19608861
35	Acetylation	EKLSDQVKISEEALR HHHHHHCCCCHHHHH	34.58	23954790
35	Ubiquitination	EKLSDQVKISEEALR HHHHHHCCCCHHHHH	34.58	-
88	Phosphorylation	YSTWKGRTIYLEDIY EEECCCCEEEEEEEE	23.73	22115753
90	Phosphorylation	TWKGRTIYLEDIYVM ECCCCEEEEEEEEEC	11.92	21712546
95	Phosphorylation	TIYLEDIYVMPEYRG EEEEEEEEECHHHCC	11.74	22115753
100	Phosphorylation	DIYVMPEYRGQGIGS EEEECHHHCCCCCCH	17.74	22115753
107	Phosphorylation	YRGQGIGSKIIKKVA HCCCCCCHHHHHHHH	20.82	21712546
108	Ubiquitination	RGQGIGSKIIKKVAE CCCCCCHHHHHHHHH	43.15	-
112	Ubiquitination	IGSKIIKKVAEVALD CCHHHHHHHHHHHHH	35.95	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SAT2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SAT2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SAT2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HIF1A_HUMAN	HIF1A	physical	17558023
SAT2_HUMAN	SAT2	physical	25416956
PANK2_HUMAN	PANK2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00127: Spermine

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-29, AND MASS SPECTROMETRY.
PubMed: 19608861