| UniProt ID | CERKL_HUMAN | |
|---|---|---|
| UniProt AC | Q49MI3 | |
| Protein Name | Ceramide kinase-like protein | |
| Gene Name | CERKL | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 558 | |
| Subcellular Localization |
Cytoplasm. Nucleus, nucleolus. Enriched in nucleoli. May shuttle between nucleus and cytoplasm. Isoform 5 is not enriched in the nucleoli. Isoform 2: Cytoplasm. Nucleus, nucleolus. Golgi apparatus, trans-Golgi network. Endoplasmic reticulum. |
|
| Protein Description | Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions.. | |
| Protein Sequence | MPWRRRRNRVSALEGGREEEAPPEAAAVPPALLTSPQQTEAAAERILLRGIFEIGRDSCDVVLSERALRWRPIQPERPAGDSKYDLLCKEEFIELKDIFSVKLKRRCSVKQQRSGTLLGITLFICLKKEQNKLKNSTLDLINLSEDHCDIWFRQFKKILAGFPNRPKSLKILLNPQSHKKEATQVYYEKVEPLLKLAGIKTDVTIMEYEGHALSLLKECELQGFDGGHRKPLFAIHWSVQRLFTGMQTLEPSVVCVGGDGSASEVAHALLLRAQKNAGMETDRILTPVRAQLPLGLIPAGSTNVLAHSLHGVPHVITATLHIIMGHVQLVDVCTFSTAGKLLRFGFSAMFGFGGRTLALAEKYRWMSPNQRRDFAVVKALAKLKAEDCEISFLPFNSSDDVQERRAQGSPKSDCNDQWQMIQGQFLNVSIMAIPCLCSVAPRGLAPNTRLNNGSMALIIARNTSRPEFIKHLKRYASVKNQFNFPFVETYTVEEVKVHPRNNTGGYNPEEEEDETASENCFPWNVDGDLMEVASEVHIRLHPRLISLYGGSMEEMIPK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 82 | Phosphorylation | PERPAGDSKYDLLCK CCCCCCCCCHHEEEH | 32.00 | - | |
| 204 (in isoform 7) | Phosphorylation | - | 19.88 | 24260401 | |
| 207 (in isoform 7) | Phosphorylation | - | 36.26 | 24260401 | |
| 214 | Phosphorylation | EYEGHALSLLKECEL EECCHHHHHHHHCHH | 32.22 | 24719451 | |
| 230 | Methylation | GFDGGHRKPLFAIHW CCCCCCCCCCEEEHH | 40.16 | - | |
| 275 | Methylation | ALLLRAQKNAGMETD HHHHHHHHHCCCCCC | 48.02 | 23644510 | |
| 340 | Ubiquitination | CTFSTAGKLLRFGFS EEECCCHHHHHHCCC | 41.71 | - | |
| 363 | Phosphorylation | TLALAEKYRWMSPNQ HHHHHHHHCCCCCCC | 10.87 | 28509920 | |
| 546 | Phosphorylation | RLHPRLISLYGGSME HHCHHHHHHHCCCHH | 21.82 | 21060948 | |
| 548 | Phosphorylation | HPRLISLYGGSMEEM CHHHHHHHCCCHHHH | 16.79 | 30622161 | |
| 551 | Phosphorylation | LISLYGGSMEEMIPK HHHHHCCCHHHHCCC | 20.75 | 28064214 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CERKL_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CERKL_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CERKL_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| VHL_HUMAN | VHL | physical | 26296657 | |
| MICA3_HUMAN | MICAL3 | physical | 28514442 | |
| PPM1A_HUMAN | PPM1A | physical | 28514442 | |
| SIR1_HUMAN | SIRT1 | physical | 28514442 | |
| PPM1B_HUMAN | PPM1B | physical | 28514442 | |
| PPM1G_HUMAN | PPM1G | physical | 28514442 | |
| EIF3I_HUMAN | EIF3I | physical | 28514442 | |
| ERBIN_HUMAN | ERBB2IP | physical | 28514442 | |
| EIF3G_HUMAN | EIF3G | physical | 28514442 | |
| ANKH1_HUMAN | ANKHD1 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 608380 | Retinitis pigmentosa 26 (RP26) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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