PK1L3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PK1L3_HUMAN
• UniProt AC: Q7Z443
• Protein Name: Polycystic kidney disease protein 1-like 3
• Gene Name: PKD1L3
• Organism: Homo sapiens (Human).
• Sequence Length: 1732
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Interaction with PKD2L1 is required for localization to the cell membrane.
• Protein Description: Component of a calcium channel. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect..
• Protein Sequence: MFFKGGSWLWLYIRTSIILGSELNSPAPHGQNNCYQLNRFQCSFEEAQHYCHVQRGFLAHIWNKEVQDLIRDYLEEGKKWWIGQNVMPLKKHQDNKYPADVAANGPPKPLSCTYLSRNFIRISSKGDKCLLKYYFICQTGDFLDGDAHYERNGNNSHLYQRHKKTKRGVAIARDKMPPGPGHLPTTCHYPLPAHLSKTLCHPISQFPSVLSSITSQVTSAASEPSSQPLPVITQLTMPVSVTHAGQSLAETTSSPKEEGHPNTFTSYLQVSLQKASGQVIDEIAGNFSRAVHGLQALNKLQEACEFLQKLTALTPRFSKPAQVNLINSLIYLSEELLRIPFQNNNSLGFKVPPTVCPFHSLNNVTKAGEGSWLESKRHTEPVEDILEMSLVEFGNIGEAFLEQNQSPESSVTLTSANATLLLSRQNISTLPLSSYTLGHPAPVRLGFPSALALKELLNKHPGVNVQITGLAFNPFKDLDNRNIVGSIGSVLLSANRKLLQVHDLMEDIEIMLWRNVSLETHPTSLNMSTHQLTITVNVTSLEKSLIVSIDPDSPLLMTLYLGFQYQPNCTHFHLNITLPKDKVWQKDEEYTWVLNPEHLQHGIGTYYITAVLSERQEGAQQTPSLVSVITAVTQCYYWEIHNQTWSSAGCQVGPQSTILRTQCLCNHLTFFASDFFVVPRTVNVEDTIKLFLRVTNNPVGVSLLASLLGFYVITVVWARKKDQADMQKVKVTVLADNDPSAQFHYLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTWTSLGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELDRVFIPVSKRELFSFRHLFSSMIVEKFTQDYLWLSIATRHPWNQFTRVQRLSCCMTLLLCNMVINVMFWKINSTTAKRDEQMRPFAVAWSELLVSIHTAVILFPINLVIGRLFPLIEPQETLPLFPPIQASCLSDASVEPLSATMVVEELKETVRFLLRRNTYLLSKCEQPPWSSWDITKLVKLLSSLVSSHLEGQGCHQQGERHWARVVPENHHHFCCYLHRVLQRLKSHLGTLGLTQGHQSCDFLDAASQLQKLQELLETHILPTEQEPSREVTSFAILSSEEGKKPISNGLSKWLTSVCWLLLGFTSLASAFFTALYSLELSKDQATSWMISIILSVLQNIFISQPVKVVFFTFLYSLMMSRMPRLNKENEQQTKRILALLAKCSSSVPGSRDKNNPVYVAPAINSPTKHPERTLKKKKLFKLTGDILVQILFLTLLMTAIYSAKNSNRFYLHQAIWKTFSHQFSEIKLLQDFYPWANHILLPSLYGDYRGKNAVLEPSHCKCGVQLIFQIPRTKTYEKVDEGQLAFCDNGHTCGRPKSLFPGLHLRRFSYICSPRPMVLIPTDELHERLTSKNENGFSYIMRGAFFTSLRLESFTSLQMSKKGCVWSIISQVIYYLLVCYYAFIQGCQLKQQKWRFFTGKRNILDTSIILISFILLGLDMKSISLHKKNMARYRDDQDRFISFYEAVKVNSAATHLVGFPVLLATVQLWNLLRHSPRLRVISRTLSRAWDEVVGFLLIILILLTGYAIAFNLLFGCSISDYRTFFSSAVTVVGLLMGISHQEEVFALDPVLGTFLILTSVILMVLVVINLFVSAILMAFGKERKSLKKEAALIDTLLQKLSNLLGISWPQKTSSEQAATTAVGSDTEVLDELP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
286	N-linked_Glycosylation	VIDEIAGNFSRAVHG HHHHHHHCHHHHHHH	23.77	UniProtKB CARBOHYD
318	Phosphorylation	TALTPRFSKPAQVNL HHHCCCCCCCHHHHH	38.72	-
363	N-linked_Glycosylation	CPFHSLNNVTKAGEG CCCCCCCCCCCCCCC	48.40	UniProtKB CARBOHYD
371	Phosphorylation	VTKAGEGSWLESKRH CCCCCCCCHHHCCCC	24.96	-
375	Phosphorylation	GEGSWLESKRHTEPV CCCCHHHCCCCCCCH	32.59	23403867
428	Phosphorylation	LLSRQNISTLPLSSY EEECCCCCCCCCCHH	31.29	22210691
449	Phosphorylation	PVRLGFPSALALKEL CCCCCCCHHHHHHHH	33.38	-
515	N-linked_Glycosylation	IEIMLWRNVSLETHP HHHHHHCCCCCCCCC	19.02	UniProtKB CARBOHYD
537	N-linked_Glycosylation	HQLTITVNVTSLEKS CEEEEEEEEEECCCE	23.77	UniProtKB CARBOHYD
575	N-linked_Glycosylation	NCTHFHLNITLPKDK CCEEEEEEEECCCCC	19.34	UniProtKB CARBOHYD
711	Phosphorylation	LASLLGFYVITVVWA HHHHHHHHHHEEEEE	6.80	-
714	Phosphorylation	LLGFYVITVVWARKK HHHHHHHEEEEECCC	10.04	-
768	Phosphorylation	AKVVITLYGSEGRSE CEEEEEECCCCCCCC	15.23	-
770	Phosphorylation	VVITLYGSEGRSEPH EEEEECCCCCCCCCC	24.26	-
869	Phosphorylation	VSKRELFSFRHLFSS CCHHHHHHHHHHHHH	33.71	24719451
883	Phosphorylation	SMIVEKFTQDYLWLS HHHHHHHCCHHHHHH	31.44	-
886	Phosphorylation	VEKFTQDYLWLSIAT HHHHCCHHHHHHHHC	7.03	-
890	Phosphorylation	TQDYLWLSIATRHPW CCHHHHHHHHCCCCC	9.90	-
893	Phosphorylation	YLWLSIATRHPWNQF HHHHHHHCCCCCCCC	28.04	-
1018	Phosphorylation	FLLRRNTYLLSKCEQ HHHHCCCHHHHCCCC	14.81	-
1117	Phosphorylation	KLQELLETHILPTEQ HHHHHHHCCCCCCCC	17.74	-
1132	Phosphorylation	EPSREVTSFAILSSE CCCCCCCEEEEECCC	20.18	-
1146	Phosphorylation	EEGKKPISNGLSKWL CCCCCCCCHHHHHHH	33.11	21955146
1150	Phosphorylation	KPISNGLSKWLTSVC CCCCHHHHHHHHHHH	24.16	21955146
1332	Phosphorylation	IKLLQDFYPWANHIL HHHHHHHHHHHHHCH	13.22	29978859
1342	Phosphorylation	ANHILLPSLYGDYRG HHHCHHHHHHCCCCC	33.90	29978859
1344	Phosphorylation	HILLPSLYGDYRGKN HCHHHHHHCCCCCCC	16.58	29978859
1347	Phosphorylation	LPSLYGDYRGKNAVL HHHHHCCCCCCCCCC	19.53	29978859
1372	Phosphorylation	LIFQIPRTKTYEKVD EEEECCCCCCCEECC	23.53	-
1511	Phosphorylation	DTSIILISFILLGLD HHHHHHHHHHHHCCC	11.64	-
1541	Phosphorylation	DDQDRFISFYEAVKV CCHHHHHHHHHHHHH	21.04	-
1574	Phosphorylation	LWNLLRHSPRLRVIS HHHHHHCCCHHHHHH	12.79	17081983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PK1L3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PK1L3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PK1L3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PK1L3_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.