DGKI_HUMAN - dbPTM
DGKI_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DGKI_HUMAN
UniProt AC O75912
Protein Name Diacylglycerol kinase iota
Gene Name DGKI
Organism Homo sapiens (Human).
Sequence Length 1065
Subcellular Localization Cytoplasm. Nucleus.
Protein Description
Protein Sequence MDAAGRGCHLLPLPAARGPARAPAAAAAAAASPPGPCSGAACAPSAAAGAGAMNPSSSAGEEKGATGGSSSSGSGAGSCCLGAEGGADPRGAGSAAAAGAAALDEPAAAGQKEKDEALEEKLRNLTFRKQVSYRKAISRAGLQHLAPAHPLSLPVANGPAKEPRATLDWSENAVNGEHLWLETNVSGDLCYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQLEKINFRCKPTFREGGSRSPRENFVRHHWVHRRRQEGKCKQCGKGFQQKFSFHSKEIVAISCSWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSLKASNRKKKRTSFKRKASKRGMEQENKGRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKDALELYRKVPNLRILACGGDGTVGWILSILDELQLSPQPPVGVLPLGTGNDLARTLNWGGGYTDEPVSKILCQVEDGTVVQLDRWNLHVERNPDLPPEELEDGVCKLPLNVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTDLTPKIQELKFQCIVFLNIPRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVIGFTMASLAALQVGGHGERLHQCREVMLLTYKSIPMQVDGEPCRLAPAMIRISLRNQANMVQKSKRRTSMPLLNDPQSVPDRLRIRVNKISLQDYEGFHYDKEKLREASISDWLRTIAGELVQSFGAIPLGILVVRGDCDLETCRMYIDRLQEDLQSVSSGSQRVHYQDHETSFPRALSAQRLSPRWCFLDDRSQEHLHFVMEISQDEIFILDPDMVVSQPAGTPPGMPDLVVEQASGISDWWNPALRKRMLSDSGLGMIAPYYEDSDLKDLSHSRVLQSPVSSEDHAILQAVIAGDLMKLIESYKNGGSLLIQGPDHCSLLHYAAKTGNGEIVKYILDHGPSELLDMADSETGETALHKAACQRNRAVCQLLVDAGASLRKTDSKGKTPQERAQQAGDPDLAAYLESRQNYKVIGHEDLETAV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
296AcetylationCKQAFHNKVTCFMLH
HHHHHCCCCCEEEEE		30.287427257
367AcetylationKGRPFVIKPISSPLM
CCCCCEEECCCCCCC		30.887695775
553UbiquitinationSREANPEKFNSRFRN
HHCCCHHHHHHHHHH		51.61-
591PhosphorylationVKVVCDGTDLTPKIQ
CEEEECCCCCCHHHH		18.00-
594PhosphorylationVCDGTDLTPKIQELK
EECCCCCCHHHHHCC		25.91-
709PhosphorylationVQKSKRRTSMPLLND
HHHCCCCCCCCCCCC		33.1527732954
710PhosphorylationQKSKRRTSMPLLNDP
HHCCCCCCCCCCCCC		19.3227732954
788PhosphorylationDLETCRMYIDRLQED
CHHHHHHHHHHHHHH		4.7425278378
798PhosphorylationRLQEDLQSVSSGSQR
HHHHHHHHCCCCCCC		31.1225278378
800PhosphorylationQEDLQSVSSGSQRVH
HHHHHHCCCCCCCEE		33.9425278378
801PhosphorylationEDLQSVSSGSQRVHY
HHHHHCCCCCCCEEE		40.0625278378
803PhosphorylationLQSVSSGSQRVHYQD
HHHCCCCCCCEEECC		19.4325278378
820PhosphorylationTSFPRALSAQRLSPR
CCCCHHHHCCCCCCC		22.7521712546
825PhosphorylationALSAQRLSPRWCFLD
HHHCCCCCCCEEEEC		18.0122199227
894PhosphorylationALRKRMLSDSGLGMI
HHHHHHHCCCCCCCC		22.0127732954
896PhosphorylationRKRMLSDSGLGMIAP
HHHHHCCCCCCCCCC		32.3227732954
921PhosphorylationSHSRVLQSPVSSEDH
CCCCCCCCCCCCCHH		24.1024076635
924PhosphorylationRVLQSPVSSEDHAIL
CCCCCCCCCCHHHHH		31.2427732954
925PhosphorylationVLQSPVSSEDHAILQ
CCCCCCCCCHHHHHH		47.4827732954
951PhosphorylationESYKNGGSLLIQGPD
HHHHCCCCEEEECCC		22.7727732954
961PhosphorylationIQGPDHCSLLHYAAK
EECCCCHHHHHHHHH		30.4627732954
1020PhosphorylationLLVDAGASLRKTDSK
HHHHHCCHHCCCCCC		27.9926437602
1049PhosphorylationDLAAYLESRQNYKVI
HHHHHHHHHCCCEEE		36.2522817900
1053PhosphorylationYLESRQNYKVIGHED
HHHHHCCCEEECCHH		9.7822817900
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DGKI_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DGKI_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DGKI_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
VHL_HUMANVHLphysical
17986458
GRP3_HUMANRASGRP3physical
15894621
RAP1A_HUMANRAP1Aphysical
15894621
AP2M1_HUMANAP2M1physical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DGKI_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1049 AND TYR-1053, ANDMASS SPECTROMETRY.

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