GRP3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRP3_HUMAN
• UniProt AC: Q8IV61
• Protein Name: Ras guanyl-releasing protein 3
• Gene Name: RASGRP3
• Organism: Homo sapiens (Human).
• Sequence Length: 690
• Protein Description: Guanine nucleotide exchange factor (GEF) for Ras and Rap1..
• Protein Sequence: MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRKISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRVHAGVDVVDRGTEFELDQDEGEETRQDGEDG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	Phosphorylation	VLLMHRWYLSSTELA HHHHHCHHHCHHHHH	9.17	-
133	Phosphorylation	YDWMRRVTQRKKVSK HHHHHHHHHHHCCCC	22.35	15657177
179	Phosphorylation	SFTDYQSYVIHGCLE ECCCCHHHHEEHHHH	6.46	-
257	Ubiquitination	HSSISRLKETHSHLS HHHHHHHHHHHHHHC	60.50	-
385	Phosphorylation	LVLEPRNSKSQPTSP EEECCCCCCCCCCCC	34.66	30576142
387 (in isoform 2)	Phosphorylation	-	41.01	22210691
387	Phosphorylation	LEPRNSKSQPTSPTT ECCCCCCCCCCCCCC	41.01	30108239
389 (in isoform 2)	Phosphorylation	-	41.77	26852163
390 (in isoform 2)	Phosphorylation	-	39.44	25159151
390	Phosphorylation	RNSKSQPTSPTTPNK CCCCCCCCCCCCCCC	39.44	30576142
391	Phosphorylation	NSKSQPTSPTTPNKP CCCCCCCCCCCCCCC	27.25	30108239
392 (in isoform 2)	Phosphorylation	-	42.65	26852163
393 (in isoform 2)	Phosphorylation	-	55.44	26852163
393	Phosphorylation	KSQPTSPTTPNKPVV CCCCCCCCCCCCCCE	55.44	30576142
394	Phosphorylation	SQPTSPTTPNKPVVP CCCCCCCCCCCCCEE	28.40	30108239
470	Phosphorylation	KDQDGLISKDEMMAY CCCCCCCCHHHHHHH	38.81	24719451
552	Phosphorylation	RRFARAPSLSSGHGS HHHHCCCCCCCCCCC	39.64	30108239
554	Phosphorylation	FARAPSLSSGHGSLP HHCCCCCCCCCCCCC	38.31	30108239
555	Phosphorylation	ARAPSLSSGHGSLPG HCCCCCCCCCCCCCC	39.85	30108239
559	Phosphorylation	SLSSGHGSLPGSPSL CCCCCCCCCCCCCCC	26.22	30108239
563	Phosphorylation	GHGSLPGSPSLPPAQ CCCCCCCCCCCCCCC	14.91	30108239
565	Phosphorylation	GSLPGSPSLPPAQDE CCCCCCCCCCCCCCC	56.03	30108239
595	Phosphorylation	SRAITLVTGSSRKIS CCEEEEEECCCCEEE	34.16	28060719
597	Phosphorylation	AITLVTGSSRKISVR EEEEEECCCCEEEEE	20.01	27535140
598	Phosphorylation	ITLVTGSSRKISVRL EEEEECCCCEEEEEE	38.65	28060719
610	Phosphorylation	VRLQRATTSQATQTE EEEEECCCCCCCCCC	20.18	28270605
611	Phosphorylation	RLQRATTSQATQTEP EEEECCCCCCCCCCC	17.29	27486199
614	Phosphorylation	RATTSQATQTEPVWS ECCCCCCCCCCCCCC	28.52	27486199
616	Phosphorylation	TTSQATQTEPVWSEA CCCCCCCCCCCCCCC	37.59	27486199
621	Phosphorylation	TQTEPVWSEAGWGDS CCCCCCCCCCCCCCC	20.15	28270605
628	Phosphorylation	SEAGWGDSGSHTFPK CCCCCCCCCCCCCHH	37.95	30108239
630	Phosphorylation	AGWGDSGSHTFPKMK CCCCCCCCCCCHHHH	24.25	30108239
632	Phosphorylation	WGDSGSHTFPKMKSK CCCCCCCCCHHHHHH	43.24	30108239
638	Phosphorylation	HTFPKMKSKFHDKAA CCCHHHHHHHCHHHH	36.74	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
133	T	Phosphorylation	Kinase	PRKCD	Q05655	GPS
133	T	Phosphorylation	Kinase	PRKCQ	Q04759	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRP3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRP3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KPCD_HUMAN	PRKCD	physical	15213298
A4_HUMAN	APP	physical	21832049
ST1C2_HUMAN	SULT1C2	physical	21988832
DYL2_HUMAN	DYNLL2	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.