MKRN2_HUMAN - dbPTM
MKRN2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MKRN2_HUMAN
UniProt AC Q9H000
Protein Name Probable E3 ubiquitin-protein ligase makorin-2
Gene Name MKRN2
Organism Homo sapiens (Human).
Sequence Length 416
Subcellular Localization
Protein Description E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins..
Protein Sequence MSTKQITCRYFMHGVCREGSQCLFSHDLANSKPSTICKYYQKGYCAYGTRCRYDHTRPSAAAGGAVGTMAHSVPSPAFHSPHPPSEVTASIVKTNSHEPGKREKRTLVLRDRNLSGMAERKTQPSMVSNPGSCSDPQPSPEMKPHSYLDAIRSGLDDVEASSSYSNEQQLCPYAAAGECRFGDACVYLHGEVCEICRLQVLHPFDPEQRKAHEKICMLTFEHEMEKAFAFQASQDKVCSICMEVILEKASASERRFGILSNCNHTYCLSCIRQWRCAKQFENPIIKSCPECRVISEFVIPSVYWVEDQNKKNELIEAFKQGMGKKACKYFEQGKGTCPFGSKCLYRHAYPDGRLAEPEKPRKQLSSQGTVRFFNSVRLWDFIENRESRHVPNNEDVDMTELGDLFMHLSGVESSEP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Ubiquitination----MSTKQITCRYF
----CCCHHHHHHHH		32.18-
4Ubiquitination----MSTKQITCRYF
----CCCHHHHHHHH		32.1822505724
4Acetylation----MSTKQITCRYF
----CCCHHHHHHHH		32.1825953088
38UbiquitinationSKPSTICKYYQKGYC
CCCCCHHHHHHCCCE		43.0423000965
42UbiquitinationTICKYYQKGYCAYGT
CHHHHHHCCCEECCC		35.4123000965
44PhosphorylationCKYYQKGYCAYGTRC
HHHHHCCCEECCCCC		4.87-
49PhosphorylationKGYCAYGTRCRYDHT
CCCEECCCCCCCCCC		17.5827251275
52MethylationCAYGTRCRYDHTRPS
EECCCCCCCCCCCCC		36.30115483329
57MethylationRCRYDHTRPSAAAGG
CCCCCCCCCCHHHCC		21.54115483337
58UbiquitinationCRYDHTRPSAAAGGA
CCCCCCCCCHHHCCC		29.4929967540
59PhosphorylationRYDHTRPSAAAGGAV
CCCCCCCCHHHCCCH		27.5226552605
68PhosphorylationAAGGAVGTMAHSVPS
HHCCCHHHCCCCCCC		12.4626552605
72PhosphorylationAVGTMAHSVPSPAFH
CHHHCCCCCCCCCCC		26.6226552605
75PhosphorylationTMAHSVPSPAFHSPH
HCCCCCCCCCCCCCC		27.0626552605
80PhosphorylationVPSPAFHSPHPPSEV
CCCCCCCCCCCCCHH		20.6024425749
85PhosphorylationFHSPHPPSEVTASIV
CCCCCCCCHHEEEEE		49.5024425749
88PhosphorylationPHPPSEVTASIVKTN
CCCCCHHEEEEEECC		15.6126552605
90PhosphorylationPPSEVTASIVKTNSH
CCCHHEEEEEECCCC		20.6726552605
94PhosphorylationVTASIVKTNSHEPGK
HEEEEEECCCCCCCC		30.9322210691
96PhosphorylationASIVKTNSHEPGKRE
EEEEECCCCCCCCCC		34.1622210691
100UbiquitinationKTNSHEPGKREKRTL
ECCCCCCCCCCCCEE		38.3729967540
100UbiquitinationKTNSHEPGKREKRTL
ECCCCCCCCCCCCEE		38.37-
101UbiquitinationTNSHEPGKREKRTLV
CCCCCCCCCCCCEEE		69.0129967540
106PhosphorylationPGKREKRTLVLRDRN
CCCCCCCEEEEECCC		32.0825106551
115PhosphorylationVLRDRNLSGMAERKT
EEECCCCCHHHCCCC		30.0323401153
122PhosphorylationSGMAERKTQPSMVSN
CHHHCCCCCCCCCCC		52.5123090842
125PhosphorylationAERKTQPSMVSNPGS
HCCCCCCCCCCCCCC		23.2323090842
128PhosphorylationKTQPSMVSNPGSCSD
CCCCCCCCCCCCCCC		28.7623090842
132PhosphorylationSMVSNPGSCSDPQPS
CCCCCCCCCCCCCCC		16.2322199227
134PhosphorylationVSNPGSCSDPQPSPE
CCCCCCCCCCCCCCC		54.7630108239
139PhosphorylationSCSDPQPSPEMKPHS
CCCCCCCCCCCCCCH		28.3923401153
143UbiquitinationPQPSPEMKPHSYLDA
CCCCCCCCCCHHHHH		37.6129967540
146PhosphorylationSPEMKPHSYLDAIRS
CCCCCCCHHHHHHHH		35.6030108239
147PhosphorylationPEMKPHSYLDAIRSG
CCCCCCHHHHHHHHC		12.9330108239
164PhosphorylationDVEASSSYSNEQQLC
CHHHCCCCCCCCCCC		19.9122817900
171UbiquitinationYSNEQQLCPYAAAGE
CCCCCCCCCHHCCCC		1.79-
171UbiquitinationYSNEQQLCPYAAAGE
CCCCCCCCCHHCCCC		1.7929967540
173PhosphorylationNEQQLCPYAAAGECR
CCCCCCCHHCCCCCC		14.1025147952
183UbiquitinationAGECRFGDACVYLHG
CCCCCCCCEEEEECC		33.8032015554
214UbiquitinationEQRKAHEKICMLTFE
HHHHHHHHHHHHHCH		31.1929967540
226UbiquitinationTFEHEMEKAFAFQAS
HCHHHHHHHHHHHCC		47.7132015554
235UbiquitinationFAFQASQDKVCSICM
HHHHCCHHHHHHHHH		42.74-
235UbiquitinationFAFQASQDKVCSICM
HHHHCCHHHHHHHHH		42.7423000965
243UbiquitinationKVCSICMEVILEKAS
HHHHHHHHHHHHHHC		23.22-
243UbiquitinationKVCSICMEVILEKAS
HHHHHHHHHHHHHHC		23.2229967540
267UbiquitinationSNCNHTYCLSCIRQW
CCCCCHHHHHHHHHH		2.0722505724
267UbiquitinationSNCNHTYCLSCIRQW
CCCCCHHHHHHHHHH		2.07-
268UbiquitinationNCNHTYCLSCIRQWR
CCCCHHHHHHHHHHH		3.09-
268UbiquitinationNCNHTYCLSCIRQWR
CCCCHHHHHHHHHHH		3.0929967540
269PhosphorylationCNHTYCLSCIRQWRC
CCCHHHHHHHHHHHH		12.1624719451
276UbiquitinationSCIRQWRCAKQFENP
HHHHHHHHHHHCCCC		5.17-
276UbiquitinationSCIRQWRCAKQFENP
HHHHHHHHHHHCCCC		5.1732015554
278UbiquitinationIRQWRCAKQFENPII
HHHHHHHHHCCCCHH		60.1823000965
282UbiquitinationRCAKQFENPIIKSCP
HHHHHCCCCHHHHCC		34.0729967540
285UbiquitinationKQFENPIIKSCPECR
HHCCCCHHHHCCCCC		2.57-
285UbiquitinationKQFENPIIKSCPECR
HHCCCCHHHHCCCCC		2.5729967540
286AcetylationQFENPIIKSCPECRV
HCCCCHHHHCCCCCE		46.8825953088
286UbiquitinationQFENPIIKSCPECRV
HCCCCHHHHCCCCCE		46.8829967540
291UbiquitinationIIKSCPECRVISEFV
HHHHCCCCCEEEECC		2.25-
291UbiquitinationIIKSCPECRVISEFV
HHHHCCCCCEEEECC		2.2527667366
299UbiquitinationRVISEFVIPSVYWVE
CEEEECCCCCEEEEC		2.2732015554
299UbiquitinationRVISEFVIPSVYWVE
CEEEECCCCCEEEEC		2.27-
310UbiquitinationYWVEDQNKKNELIEA
EEECCCCHHHHHHHH		51.8722505724
311UbiquitinationWVEDQNKKNELIEAF
EECCCCHHHHHHHHH		64.3029967540
316UbiquitinationNKKNELIEAFKQGMG
CHHHHHHHHHHHCCC		61.7629967540
316UbiquitinationNKKNELIEAFKQGMG
CHHHHHHHHHHHCCC		61.76-
319UbiquitinationNELIEAFKQGMGKKA
HHHHHHHHHCCCHHH		53.6532015554
319UbiquitinationNELIEAFKQGMGKKA
HHHHHHHHHCCCHHH		53.65-
325UbiquitinationFKQGMGKKACKYFEQ
HHHCCCHHHHHHHHC		53.9729967540
328UbiquitinationGMGKKACKYFEQGKG
CCCHHHHHHHHCCCC		58.8129967540
334UbiquitinationCKYFEQGKGTCPFGS
HHHHHCCCCCCCCCC		51.2227667366
336PhosphorylationYFEQGKGTCPFGSKC
HHHCCCCCCCCCCCE		22.08-
342UbiquitinationGTCPFGSKCLYRHAY
CCCCCCCCEEHHCCC		28.7432015554
359UbiquitinationGRLAEPEKPRKQLSS
CCCCCCCCCCHHHCC		61.9229967540
362UbiquitinationAEPEKPRKQLSSQGT
CCCCCCCHHHCCCCC		65.2127667366
365PhosphorylationEKPRKQLSSQGTVRF
CCCCHHHCCCCCEEE		20.3728857561
366PhosphorylationKPRKQLSSQGTVRFF
CCCHHHCCCCCEEEC		41.02-
369PhosphorylationKQLSSQGTVRFFNSV
HHHCCCCCEEECCCE		10.8126437602
375PhosphorylationGTVRFFNSVRLWDFI
CCEEECCCEEHHHHH		11.9423186163
409PhosphorylationGDLFMHLSGVESSEP
HHHHHHHHCCCCCCC		26.5627251275
413PhosphorylationMHLSGVESSEP----
HHHHCCCCCCC----		37.2827251275
414PhosphorylationHLSGVESSEP-----
HHHCCCCCCC-----		40.1427251275
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MKRN2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MKRN2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MKRN2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
UB2D4_HUMANUBE2D4physical
25416956
CA109_HUMANC1orf109physical
25416956
PDLI2_HUMANPDLIM2physical
28378844
TF65_HUMANRELAphysical
28378844
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MKRN2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-139, AND MASSSPECTROMETRY.

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