PDLI2_HUMAN - dbPTM
PDLI2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PDLI2_HUMAN
UniProt AC Q96JY6
Protein Name PDZ and LIM domain protein 2
Gene Name PDLIM2
Organism Homo sapiens (Human).
Sequence Length 352
Subcellular Localization Cytoplasm . Nucleus . May be partially nuclear.
Isoform 1: Cytoplasm, cytoskeleton. Colocalizes with beta-1 integrin (ITGB1) and alpha-actinin but not with paxillin (PXN).
Isoform 2: Cytoplasm, cytoskeleton.
Isoform 3: Nucleus.
Protein Description Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity..
Protein Sequence MALTVDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGMLHAEAQSKIRQSPSPLRLQLDRSQATSPGQTNGDSSLEVLATRFQGSVRTYTESQSSLRSSYSSPTSLSPRAGSPFSPPPSSSSLTGEAAISRSFQSLACSPGLPAADRLSYSGRPGSRQAGLGRAGDSAVLVLPPSPGPRSSRPSMDSEGGSLLLDEDSEVFKMLQENREGRAAPRQSSSFRLLQEALEAEERGGTPAFLPSSLSPQSSLPASRALATPPKLHTCEKCSTSIANQAVRIQEGRYRHPGCYTCADCGLNLKMRGHFWVGDELYCEKHARQRYSAPATLSSRA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
25PhosphorylationTGGRDFHTPIMVTKV
CCCCCCCCCEEEEEH		17.9524719451
30PhosphorylationFHTPIMVTKVAERGK
CCCCEEEEEHHHHCC		11.4727251275
72PhosphorylationAQSKIRQSPSPLRLQ
HHHHHCCCCCCCEEE		19.9330266825
74PhosphorylationSKIRQSPSPLRLQLD
HHHCCCCCCCEEEEC		41.6430266825
83PhosphorylationLRLQLDRSQATSPGQ
CEEEECHHHCCCCCC		24.6730266825
86PhosphorylationQLDRSQATSPGQTNG
EECHHHCCCCCCCCC		28.0230266825
87PhosphorylationLDRSQATSPGQTNGD
ECHHHCCCCCCCCCC		30.0130266825
91PhosphorylationQATSPGQTNGDSSLE
HCCCCCCCCCCCHHH		47.2719690332
95PhosphorylationPGQTNGDSSLEVLAT
CCCCCCCCHHHHHHH		37.9230266825
96PhosphorylationGQTNGDSSLEVLATR
CCCCCCCHHHHHHHE		33.0330266825
107PhosphorylationLATRFQGSVRTYTES
HHHEECCEEEEEECC		9.5328985074
110PhosphorylationRFQGSVRTYTESQSS
EECCEEEEEECCHHH		32.4128796482
111PhosphorylationFQGSVRTYTESQSSL
ECCEEEEEECCHHHH		9.6528796482
112PhosphorylationQGSVRTYTESQSSLR
CCEEEEEECCHHHHH		28.6628450419
114PhosphorylationSVRTYTESQSSLRSS
EEEEEECCHHHHHHC		27.8028450419
116PhosphorylationRTYTESQSSLRSSYS
EEEECCHHHHHHCCC		40.3928450419
117PhosphorylationTYTESQSSLRSSYSS
EEECCHHHHHHCCCC		21.8423401153
120PhosphorylationESQSSLRSSYSSPTS
CCHHHHHHCCCCCCC		38.6323927012
121PhosphorylationSQSSLRSSYSSPTSL
CHHHHHHCCCCCCCC		23.7023927012
122PhosphorylationQSSLRSSYSSPTSLS
HHHHHHCCCCCCCCC		17.8923927012
123PhosphorylationSSLRSSYSSPTSLSP
HHHHHCCCCCCCCCC		31.6123401153
124PhosphorylationSLRSSYSSPTSLSPR
HHHHCCCCCCCCCCC		24.7823927012
126PhosphorylationRSSYSSPTSLSPRAG
HHCCCCCCCCCCCCC		44.2230278072
127PhosphorylationSSYSSPTSLSPRAGS
HCCCCCCCCCCCCCC		30.1823401153
129PhosphorylationYSSPTSLSPRAGSPF
CCCCCCCCCCCCCCC		16.4719664994
131MethylationSPTSLSPRAGSPFSP
CCCCCCCCCCCCCCC		48.48115388105
134O-linked_GlycosylationSLSPRAGSPFSPPPS
CCCCCCCCCCCCCCC		23.0629351928
134PhosphorylationSLSPRAGSPFSPPPS
CCCCCCCCCCCCCCC		23.0623927012
137O-linked_GlycosylationPRAGSPFSPPPSSSS
CCCCCCCCCCCCCCC		39.6229351928
137PhosphorylationPRAGSPFSPPPSSSS
CCCCCCCCCCCCCCC		39.6223401153
141O-linked_GlycosylationSPFSPPPSSSSLTGE
CCCCCCCCCCCCCHH		48.9329351928
141PhosphorylationSPFSPPPSSSSLTGE
CCCCCCCCCCCCCHH		48.9330266825
141 (in isoform 5)Phosphorylation-48.9326853621
142O-linked_GlycosylationPFSPPPSSSSLTGEA
CCCCCCCCCCCCHHH		29.7129351928
142PhosphorylationPFSPPPSSSSLTGEA
CCCCCCCCCCCCHHH		29.7130266825
143O-linked_GlycosylationFSPPPSSSSLTGEAA
CCCCCCCCCCCHHHH		33.4329351928
143PhosphorylationFSPPPSSSSLTGEAA
CCCCCCCCCCCHHHH		33.4330266825
144O-linked_GlycosylationSPPPSSSSLTGEAAI
CCCCCCCCCCHHHHH		31.7229351928
144PhosphorylationSPPPSSSSLTGEAAI
CCCCCCCCCCHHHHH		31.7230266825
146O-linked_GlycosylationPPSSSSLTGEAAISR
CCCCCCCCHHHHHHH		34.6229351928
146PhosphorylationPPSSSSLTGEAAISR
CCCCCCCCHHHHHHH		34.6230266825
152O-linked_GlycosylationLTGEAAISRSFQSLA
CCHHHHHHHHHHHHH		19.6929351928
152PhosphorylationLTGEAAISRSFQSLA
CCHHHHHHHHHHHHH		19.6930266825
154PhosphorylationGEAAISRSFQSLACS
HHHHHHHHHHHHHCC		22.3527794612
157PhosphorylationAISRSFQSLACSPGL
HHHHHHHHHHCCCCC		18.8730266825
161PhosphorylationSFQSLACSPGLPAAD
HHHHHHCCCCCCHHH		19.1819664994
171PhosphorylationLPAADRLSYSGRPGS
CCHHHHCCCCCCCCC		20.3928857561
172PhosphorylationPAADRLSYSGRPGSR
CHHHHCCCCCCCCCC		21.5328857561
173PhosphorylationAADRLSYSGRPGSRQ
HHHHCCCCCCCCCCC		25.5828857561
178PhosphorylationSYSGRPGSRQAGLGR
CCCCCCCCCCCCCCC		24.7328857561
185MethylationSRQAGLGRAGDSAVL
CCCCCCCCCCCCEEE		40.20108496083
189PhosphorylationGLGRAGDSAVLVLPP
CCCCCCCCEEEEECC		21.2529255136
197PhosphorylationAVLVLPPSPGPRSSR
EEEEECCCCCCCCCC		40.3223401153
202PhosphorylationPPSPGPRSSRPSMDS
CCCCCCCCCCCCCCC		33.5623927012
203PhosphorylationPSPGPRSSRPSMDSE
CCCCCCCCCCCCCCC		49.8724702127
206PhosphorylationGPRSSRPSMDSEGGS
CCCCCCCCCCCCCCC		33.8323927012
209PhosphorylationSSRPSMDSEGGSLLL
CCCCCCCCCCCCEEE		29.5123927012
213PhosphorylationSMDSEGGSLLLDEDS
CCCCCCCCEEECCCH		27.0523927012
220PhosphorylationSLLLDEDSEVFKMLQ
CEEECCCHHHHHHHH		33.3429978859
239PhosphorylationGRAAPRQSSSFRLLQ
CCCCCCCCHHHHHHH		29.2728464451
240PhosphorylationRAAPRQSSSFRLLQE
CCCCCCCHHHHHHHH		25.7628450419
241PhosphorylationAAPRQSSSFRLLQEA
CCCCCCHHHHHHHHH		21.4528464451
257PhosphorylationEAEERGGTPAFLPSS
HHHHHCCCCCCCCCC		17.8026055452
263PhosphorylationGTPAFLPSSLSPQSS
CCCCCCCCCCCCCCC		46.1623401153
264PhosphorylationTPAFLPSSLSPQSSL
CCCCCCCCCCCCCCC		30.8125159151
266PhosphorylationAFLPSSLSPQSSLPA
CCCCCCCCCCCCCCH		23.8825159151
269PhosphorylationPSSLSPQSSLPASRA
CCCCCCCCCCCHHHH		36.9130183078
270PhosphorylationSSLSPQSSLPASRAL
CCCCCCCCCCHHHHC		32.8821712546
274PhosphorylationPQSSLPASRALATPP
CCCCCCHHHHCCCCC		19.0230183078
275 (in isoform 5)Phosphorylation-35.4124719451
279PhosphorylationPASRALATPPKLHTC
CHHHHCCCCCCCCCC		40.7623401153
282AcetylationRALATPPKLHTCEKC
HHCCCCCCCCCCCCC		54.8523954790
285PhosphorylationATPPKLHTCEKCSTS
CCCCCCCCCCCCCHH		32.5623927012
305PhosphorylationVRIQEGRYRHPGCYT
HHHCCCCCCCCCCEE		24.9128152594
311PhosphorylationRYRHPGCYTCADCGL
CCCCCCCEEECCCCC		15.6928152594
312PhosphorylationYRHPGCYTCADCGLN
CCCCCCEEECCCCCC		12.8028152594
324 (in isoform 5)Phosphorylation-19.4924719451
337 (in isoform 5)Phosphorylation-12.1224719451
341 (in isoform 5)Phosphorylation-23.0927251275
342PhosphorylationEKHARQRYSAPATLS
HHHHHHHCCCCCCCC		10.8028555341
343PhosphorylationKHARQRYSAPATLSS
HHHHHHCCCCCCCCC		29.9328857561
347O-linked_GlycosylationQRYSAPATLSSRA--
HHCCCCCCCCCCC--		26.55OGP
347PhosphorylationQRYSAPATLSSRA--
HHCCCCCCCCCCC--		26.5527251275
349PhosphorylationYSAPATLSSRA----
CCCCCCCCCCC----		17.2727251275
350PhosphorylationSAPATLSSRA-----
CCCCCCCCCC-----		35.0327251275
361 (in isoform 5)Phosphorylation-27642862
364 (in isoform 5)Phosphorylation-24719451
365 (in isoform 3)Phosphorylation--
366 (in isoform 5)Phosphorylation-27251275
370 (in isoform 5)Phosphorylation-27642862
372 (in isoform 5)Phosphorylation-27642862
373 (in isoform 5)Phosphorylation-24719451
374Phosphorylation-----------------------------
-----------------------------		20058876
374 (in isoform 5)Phosphorylation-24719451
376Phosphorylation-------------------------------
-------------------------------		20166139
376 (in isoform 5)Phosphorylation-27251275
377 (in isoform 5)Phosphorylation-24719451
379Phosphorylation----------------------------------
----------------------------------		19664994
379 (in isoform 5)Phosphorylation-27642862
384 (in isoform 5)Phosphorylation-24719451
387Phosphorylation------------------------------------------
------------------------------------------		33259812
387 (in isoform 5)Phosphorylation-24719451
391 (in isoform 5)Phosphorylation-27251275
393 (in isoform 5)Phosphorylation-27251275
404 (in isoform 5)Phosphorylation-24719451
411Phosphorylation------------------------------------------------------------------
------------------------------------------------------------------		19664994
411 (in isoform 5)Phosphorylation-24719451
421 (in isoform 5)Phosphorylation-24719451
423 (in isoform 5)Phosphorylation-27251275
428 (in isoform 5)Phosphorylation-24719451
447Phosphorylation------------------------------------------------------------------------------------------------------
------------------------------------------------------------------------------------------------------		19664995
447 (in isoform 5)Phosphorylation-24719451
452Phosphorylation-----------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------		20166139
456 (in isoform 5)Phosphorylation-24719451
459 (in isoform 5)Phosphorylation-24719451
463 (in isoform 5)Phosphorylation-27251275
489 (in isoform 5)Phosphorylation-24719451
507 (in isoform 5)Phosphorylation-24719451
514 (in isoform 5)Phosphorylation-27251275
516Phosphorylation---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------		18669648
516 (in isoform 5)Phosphorylation-24719451
520 (in isoform 5)Phosphorylation-27251275
529Phosphorylation----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		32645325
529 (in isoform 5)Phosphorylation-24719451
532Acetylation-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		19608861
593 (in isoform 5)Phosphorylation-27251275
599 (in isoform 5)Phosphorylation-27251275
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PDLI2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PDLI2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PDLI2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
UB2E2_HUMANUBE2E2physical
15963787
PDLI2_HUMANPDLIM2physical
15963787
STAT4_HUMANSTAT4physical
15963787
MKRN2_HUMANMKRN2physical
28378844
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PDLI2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-129; SER-134 ANDSER-197, AND MASS SPECTROMETRY.
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-266, AND MASSSPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-266, AND MASSSPECTROMETRY.
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-266, AND MASSSPECTROMETRY.
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-266, AND MASSSPECTROMETRY.

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