| UniProt ID | DMRT3_HUMAN | |
|---|---|---|
| UniProt AC | Q9NQL9 | |
| Protein Name | Doublesex- and mab-3-related transcription factor 3 | |
| Gene Name | DMRT3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 472 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling limb movements. May regulate transcription during sexual development (By similarity).. | |
| Protein Sequence | MNGYGSPYLYMGGPVSQPPRAPLQRTPKCARCRNHGVLSWLKGHKRYCRFKDCTCEKCILIIERQRVMAAQVALRRQQANESLESLIPDSLRALPGPPPPGDAVAAPQPPPASQPSQPQPPRPAAELAAAAALRWTAEPQPGALQAQLAKPDLTEERLGDGKSADNTEVFSDKDTDQRSSPDVAKSKGCFTPESPEIVSVEEGGYAVQKNGGNPESRPDSPKCHAEQNHLLIEGPSGTVSLPFSLKANRPPLEVLKKIFPNQKPTVLELILKGCGGDLVSAVEVLLSSRSSVTGAERTSAEPESLALPSNGHIFEHTLSSYPISSSKWSVGSAFRVPDTLRFSADSSNVVPSPLAGPLQPPFPQPPRYPLMLRNTLARSQSSPFLPNDVTLWNTMTLQQQYQLRSQYVSPFPSNSTSVFRSSPVLPARATEDPRISIPDDGCPFVSKQSIYTEDDYDERSDSSDSRTLNTSS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 42 | Acetylation | HGVLSWLKGHKRYCR CCHHHHHCCCCCCCC | 53.35 | 20167786 | |
| 167 | Phosphorylation | DGKSADNTEVFSDKD CCCCCCCCCCCCCCC | 33.79 | - | |
| 171 | Phosphorylation | ADNTEVFSDKDTDQR CCCCCCCCCCCCCCC | 49.26 | 25002506 | |
| 175 | Phosphorylation | EVFSDKDTDQRSSPD CCCCCCCCCCCCCCH | 39.51 | 25002506 | |
| 179 | Phosphorylation | DKDTDQRSSPDVAKS CCCCCCCCCCHHHHH | 40.36 | 22496350 | |
| 179 | O-linked_Glycosylation | DKDTDQRSSPDVAKS CCCCCCCCCCHHHHH | 40.36 | 30379171 | |
| 180 | Phosphorylation | KDTDQRSSPDVAKSK CCCCCCCCCHHHHHC | 27.58 | 25002506 | |
| 194 | Phosphorylation | KGCFTPESPEIVSVE CCCCCCCCCCEEEEE | 29.09 | 27251275 | |
| 205 | Phosphorylation | VSVEEGGYAVQKNGG EEEEECCEEEEECCC | 17.92 | 28674151 | |
| 216 | Phosphorylation | KNGGNPESRPDSPKC ECCCCCCCCCCCCCC | 50.82 | 22496350 | |
| 220 | Phosphorylation | NPESRPDSPKCHAEQ CCCCCCCCCCCCHHC | 29.01 | 22496350 | |
| 265 | Phosphorylation | IFPNQKPTVLELILK HCCCCCCCHHHHHHC | 44.77 | - | |
| 287 | Phosphorylation | SAVEVLLSSRSSVTG HHHHHHHHCCCCCCC | 21.39 | 24719451 | |
| 288 | Phosphorylation | AVEVLLSSRSSVTGA HHHHHHHCCCCCCCC | 35.83 | 21712546 | |
| 343 | Phosphorylation | VPDTLRFSADSSNVV CCCEEEECCCCCCCC | 25.40 | 22817900 | |
| 346 | Phosphorylation | TLRFSADSSNVVPSP EEEECCCCCCCCCCC | 24.43 | 22817900 | |
| 347 | Phosphorylation | LRFSADSSNVVPSPL EEECCCCCCCCCCCC | 33.90 | 22817900 | |
| 352 | Phosphorylation | DSSNVVPSPLAGPLQ CCCCCCCCCCCCCCC | 22.42 | 22817900 | |
| 382 | Phosphorylation | TLARSQSSPFLPNDV HHHHHCCCCCCCCCC | 16.43 | - | |
| 390 | Phosphorylation | PFLPNDVTLWNTMTL CCCCCCCEEEECCCH | 28.99 | - | |
| 396 | Phosphorylation | VTLWNTMTLQQQYQL CEEEECCCHHHHHHH | 21.26 | - | |
| 405 | Phosphorylation | QQQYQLRSQYVSPFP HHHHHHHHCCCCCCC | 34.16 | 25002506 | |
| 407 | Phosphorylation | QYQLRSQYVSPFPSN HHHHHHCCCCCCCCC | 12.25 | 23532336 | |
| 409 | Phosphorylation | QLRSQYVSPFPSNST HHHHCCCCCCCCCCC | 18.85 | 25002506 | |
| 413 | Phosphorylation | QYVSPFPSNSTSVFR CCCCCCCCCCCCCCC | 43.73 | 24114839 | |
| 415 | Phosphorylation | VSPFPSNSTSVFRSS CCCCCCCCCCCCCCC | 26.79 | 25002506 | |
| 416 | Phosphorylation | SPFPSNSTSVFRSSP CCCCCCCCCCCCCCC | 32.91 | 24114839 | |
| 417 | Phosphorylation | PFPSNSTSVFRSSPV CCCCCCCCCCCCCCC | 21.05 | 25002506 | |
| 452 | Phosphorylation | VSKQSIYTEDDYDER CCCCCEECCCCCCCC | 31.13 | 18669648 | |
| 456 | Phosphorylation | SIYTEDDYDERSDSS CEECCCCCCCCCCCC | 31.83 | 18669648 | |
| 460 | Phosphorylation | EDDYDERSDSSDSRT CCCCCCCCCCCCCCC | 39.53 | - | |
| 462 | Phosphorylation | DYDERSDSSDSRTLN CCCCCCCCCCCCCCC | 36.97 | - | |
| 463 | Phosphorylation | YDERSDSSDSRTLNT CCCCCCCCCCCCCCC | 44.59 | - | |
| 465 | Phosphorylation | ERSDSSDSRTLNTSS CCCCCCCCCCCCCCC | 29.16 | 22468782 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DMRT3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DMRT3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DMRT3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| UBS3B_HUMAN | UBASH3B | physical | 25416956 | |
| K1C40_HUMAN | KRT40 | physical | 25416956 | |
| MGT5B_HUMAN | MGAT5B | physical | 25416956 | |
| KR107_HUMAN | KRTAP10-7 | physical | 25416956 | |
| KR109_HUMAN | KRTAP10-9 | physical | 25416956 | |
| KR108_HUMAN | KRTAP10-8 | physical | 25416956 | |
| KR103_HUMAN | KRTAP10-3 | physical | 25416956 | |
| INCA1_HUMAN | INCA1 | physical | 25416956 | |
| NT2NL_HUMAN | NOTCH2NL | physical | 25416956 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
