ZN439_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN439_HUMAN
• UniProt AC: Q8NDP4
• Protein Name: Zinc finger protein 439
• Gene Name: ZNF439
• Organism: Homo sapiens (Human).
• Sequence Length: 499
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MLSLSPILLYTCEMFQDPVAFKDVAVNFTQEEWALLDISQKNLYREVMLETFWNLTSIGKKWKDQNIEYEYQNPRRNFRSVTEEKVNEIKEDSHCGETFTPVPDDRLNFQKKKASPEVKSCDSFVCEVGLGNSSSNMNIRGDTGHKACECQEYGPKPWKSQQPKKAFRYHPSLRTQERDHTGKKPYACKECGKNIIYHSSIQRHMVVHSGDGPYKCKFCGKAFHCLSLYLIHERTHTGEKPYECKQCGKSFSYSATHRIHERTHIGEKPYECQECGKAFHSPRSCHRHERSHMGEKAYQCKECGKAFMCPRYVRRHERTHSRKKLYECKQCGKALSSLTSFQTHIRMHSGERPYECKTCGKGFYSAKSFQRHEKTHSGEKPYKCKQCGKAFTRSGSFRYHERTHTGEKPYECKQCGKAFRSAPNLQLHGRTHTGEKPYQCKECGKAFRSASQLRIHRRIHTGEKPYECKKCGKAFRYVQNFRFHERTQTHKNALWRKTL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
123	Phosphorylation	PEVKSCDSFVCEVGL CCCCCCCEEEEEECC	24.73	-
135	Phosphorylation	VGLGNSSSNMNIRGD ECCCCCCCCCEECCC	39.66	-
143	Phosphorylation	NMNIRGDTGHKACEC CCEECCCCCCCCCCC	43.97	-
172	Phosphorylation	KAFRYHPSLRTQERD HHHCCCCCHHCCCCC	19.71	24719451
235	Phosphorylation	LYLIHERTHTGEKPY HHHHHCCCCCCCCCE	22.32	29396449
237	Phosphorylation	LIHERTHTGEKPYEC HHHCCCCCCCCCEEC	46.56	29496963
240	Ubiquitination	ERTHTGEKPYECKQC CCCCCCCCCEECCCC	55.00	-
245	Sumoylation	GEKPYECKQCGKSFS CCCCEECCCCCCCEE	36.36	-
245	Sumoylation	GEKPYECKQCGKSFS CCCCEECCCCCCCEE	36.36	-
254	Phosphorylation	CGKSFSYSATHRIHE CCCCEEEECCCCCCC	26.03	-
256	Phosphorylation	KSFSYSATHRIHERT CCEEEECCCCCCCCC	13.02	-
336	Phosphorylation	KQCGKALSSLTSFQT HHHHHHHHHCHHHHH	28.32	27732954
337	Phosphorylation	QCGKALSSLTSFQTH HHHHHHHHCHHHHHH	36.19	27732954
339	Phosphorylation	GKALSSLTSFQTHIR HHHHHHCHHHHHHHH	29.46	27732954
340	Phosphorylation	KALSSLTSFQTHIRM HHHHHCHHHHHHHHH	22.20	27732954
394	Phosphorylation	CGKAFTRSGSFRYHE CCCEEECCCCEEEEC	35.41	22210691
396	Phosphorylation	KAFTRSGSFRYHERT CEEECCCCEEEECCC	14.06	22210691
399	Phosphorylation	TRSGSFRYHERTHTG ECCCCEEEECCCCCC	13.16	29083192
403	Phosphorylation	SFRYHERTHTGEKPY CEEEECCCCCCCCCE	22.32	29396449
405	Phosphorylation	RYHERTHTGEKPYEC EEECCCCCCCCCEEE	46.56	29496963
408	Ubiquitination	ERTHTGEKPYECKQC CCCCCCCCCEEECCC	55.00	-
410	Phosphorylation	THTGEKPYECKQCGK CCCCCCCEEECCCCH	45.05	29083192
413	Sumoylation	GEKPYECKQCGKAFR CCCCEEECCCCHHHH	36.36	-
413	Sumoylation	GEKPYECKQCGKAFR CCCCEEECCCCHHHH	36.36	-
431	Phosphorylation	NLQLHGRTHTGEKPY CEEEECCCCCCCCCE	28.51	-
433	Phosphorylation	QLHGRTHTGEKPYQC EEECCCCCCCCCEEC	46.56	-
449	Phosphorylation	ECGKAFRSASQLRIH HHHHHHHHHHHHEEE	26.31	22985185
451	Phosphorylation	GKAFRSASQLRIHRR HHHHHHHHHHEEECC	30.87	22985185
461	Phosphorylation	RIHRRIHTGEKPYEC EEECCCCCCCCCCCC	44.67	29496963

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN439_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN439_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN439_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
K1C40_HUMAN	KRT40	physical	25416956
KR107_HUMAN	KRTAP10-7	physical	25416956
KR109_HUMAN	KRTAP10-9	physical	25416956
KR101_HUMAN	KRTAP10-1	physical	25416956
KR108_HUMAN	KRTAP10-8	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.