| UniProt ID | PIMRE_HUMAN | |
|---|---|---|
| UniProt AC | Q9BSJ6 | |
| Protein Name | Protein PIMREG {ECO:0000305} | |
| Gene Name | PIMREG {ECO:0000312|HGNC:HGNC:25483} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 248 | |
| Subcellular Localization | Nucleus . Nucleus, nucleolus . Partially localizes to the nucleolus. | |
| Protein Description | During mitosis, may play a role in the control of metaphase-to-anaphase transition.. | |
| Protein Sequence | MASRWQNMGTSVRRRSLQHQEQLEDSKELQPVVSHQETSVGALGSLCRQFQRRLPLRAVNLNLRAGPSWKRLETPEPGQQGLQAAARSAKSALGAVSQRIQESCQSGTKWLVETQVKARRRKRGAQKGSGSPTHSLSQKSTRLSGAAPAHSAADPWEKEHHRLSVRMGSHAHPLRRSRREAAFRSPYSSTEPLCSPSESDSDLEPVGAGIQHLQKLSQELDEAIMAEERKQALSDRQGFILKDVYASP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MASRWQNMGT -----CCCHHHHHCH | 22210691 | ||
| 10 | Phosphorylation | SRWQNMGTSVRRRSL CHHHHHCHHHHHHHH | 22199227 | ||
| 11 | Phosphorylation | RWQNMGTSVRRRSLQ HHHHHCHHHHHHHHH | 22199227 | ||
| 16 | Phosphorylation | GTSVRRRSLQHQEQL CHHHHHHHHHHHHHH | 29255136 | ||
| 26 | Phosphorylation | HQEQLEDSKELQPVV HHHHHCCCCCCCCCC | 22167270 | ||
| 34 | Phosphorylation | KELQPVVSHQETSVG CCCCCCCCCCHHCHH | 25850435 | ||
| 38 | Phosphorylation | PVVSHQETSVGALGS CCCCCCHHCHHHHHH | 25850435 | ||
| 39 | Phosphorylation | VVSHQETSVGALGSL CCCCCHHCHHHHHHH | 25850435 | ||
| 45 | Phosphorylation | TSVGALGSLCRQFQR HCHHHHHHHHHHHHH | 25850435 | ||
| 74 | Phosphorylation | PSWKRLETPEPGQQG CCCCCCCCCCCCHHH | 29255136 | ||
| 88 | Phosphorylation | GLQAAARSAKSALGA HHHHHHHHHHHHHHH | 21712546 | ||
| 90 | Ubiquitination | QAAARSAKSALGAVS HHHHHHHHHHHHHHH | - | ||
| 91 | Phosphorylation | AAARSAKSALGAVSQ HHHHHHHHHHHHHHH | 25159151 | ||
| 97 | Phosphorylation | KSALGAVSQRIQESC HHHHHHHHHHHHHHH | 21406692 | ||
| 103 | Phosphorylation | VSQRIQESCQSGTKW HHHHHHHHHHHCCHH | 23312004 | ||
| 106 | Phosphorylation | RIQESCQSGTKWLVE HHHHHHHHCCHHHHH | 30576142 | ||
| 108 | Phosphorylation | QESCQSGTKWLVETQ HHHHHHCCHHHHHHH | 21712546 | ||
| 114 | Phosphorylation | GTKWLVETQVKARRR CCHHHHHHHHHHHHH | 28555341 | ||
| 117 | Ubiquitination | WLVETQVKARRRKRG HHHHHHHHHHHHHHC | - | ||
| 129 | Phosphorylation | KRGAQKGSGSPTHSL HHCCCCCCCCCCCCC | 22167270 | ||
| 131 | Phosphorylation | GAQKGSGSPTHSLSQ CCCCCCCCCCCCCCH | 29255136 | ||
| 133 | Phosphorylation | QKGSGSPTHSLSQKS CCCCCCCCCCCCHHC | 30266825 | ||
| 135 | Phosphorylation | GSGSPTHSLSQKSTR CCCCCCCCCCHHCCC | 30266825 | ||
| 137 | Phosphorylation | GSPTHSLSQKSTRLS CCCCCCCCHHCCCCC | 30266825 | ||
| 140 | Phosphorylation | THSLSQKSTRLSGAA CCCCCHHCCCCCCCC | 29396449 | ||
| 141 | Phosphorylation | HSLSQKSTRLSGAAP CCCCHHCCCCCCCCC | 29396449 | ||
| 144 | Phosphorylation | SQKSTRLSGAAPAHS CHHCCCCCCCCCCCC | 25159151 | ||
| 151 | Phosphorylation | SGAAPAHSAADPWEK CCCCCCCCCCCHHHH | 29396449 | ||
| 164 | Phosphorylation | EKEHHRLSVRMGSHA HHHHHCHHHHCCCCC | 30266825 | ||
| 169 | Phosphorylation | RLSVRMGSHAHPLRR CHHHHCCCCCCCCHH | 24719451 | ||
| 177 | Phosphorylation | HAHPLRRSRREAAFR CCCCCHHHHHHHHHC | - | ||
| 185 | Phosphorylation | RREAAFRSPYSSTEP HHHHHHCCCCCCCCC | 23927012 | ||
| 187 | Phosphorylation | EAAFRSPYSSTEPLC HHHHCCCCCCCCCCC | 23927012 | ||
| 188 | Phosphorylation | AAFRSPYSSTEPLCS HHHCCCCCCCCCCCC | 28450419 | ||
| 189 | Phosphorylation | AFRSPYSSTEPLCSP HHCCCCCCCCCCCCC | 23663014 | ||
| 190 | Phosphorylation | FRSPYSSTEPLCSPS HCCCCCCCCCCCCCC | 23663014 | ||
| 195 | Phosphorylation | SSTEPLCSPSESDSD CCCCCCCCCCCCCCC | 23927012 | ||
| 197 | Phosphorylation | TEPLCSPSESDSDLE CCCCCCCCCCCCCCC | 23927012 | ||
| 199 | Phosphorylation | PLCSPSESDSDLEPV CCCCCCCCCCCCCCC | 23927012 | ||
| 201 | Phosphorylation | CSPSESDSDLEPVGA CCCCCCCCCCCCCCH | 23927012 | ||
| 217 (in isoform 2) | Phosphorylation | - | 22912867 | ||
| 230 | Acetylation | AIMAEERKQALSDRQ HHHHHHHHHHHHHCC | 19810307 | ||
| 247 | Phosphorylation | ILKDVYASP------ EECCCCCCC------ | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 131 | S | Phosphorylation | Kinase | KIS | Q8TAS1 | PSP |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PIMRE_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PIMRE_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| APRIO_HUMAN | PRNP | physical | 18482256 | |
| PRIO_HUMAN | PRNP | physical | 18482256 | |
| A4_HUMAN | APP | physical | 21832049 | |
| ATRAP_HUMAN | AGTRAP | physical | 25416956 | |
| CEP70_HUMAN | CEP70 | physical | 25416956 | |
| ADIP_HUMAN | SSX2IP | physical | 25416956 | |
| K1C40_HUMAN | KRT40 | physical | 25416956 | |
| TDRD7_HUMAN | TDRD7 | physical | 26186194 | |
| TTC19_HUMAN | TTC19 | physical | 26186194 | |
| ACD11_HUMAN | ACAD11 | physical | 26186194 | |
| PICAL_HUMAN | PICALM | physical | 26186194 | |
| TDRD7_HUMAN | TDRD7 | physical | 28514442 | |
| ZY11B_HUMAN | ZYG11B | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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