| UniProt ID | CFA65_HUMAN | |
|---|---|---|
| UniProt AC | Q6ZU64 | |
| Protein Name | Cilia- and flagella-associated protein 65 {ECO:0000305} | |
| Gene Name | CFAP65 {ECO:0000312|HGNC:HGNC:25325} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1925 | |
| Subcellular Localization |
Cell projection, cilium, flagellum membrane Single-pass membrane protein . |
|
| Protein Description | May play a role in sperm motility.. | |
| Protein Sequence | MFTLTGCRLVEKTQKVENPSVSFASSFPLIPLLLRGKSVQKKQAESKSQIKLHTQSAPFGLCPKDMMLTQAPSSVVRSRNSRNHTVNSGGSCLSASTVAIPAINDSSAAMSACSTISAQPASSMDTQMHSPKKQERVNKRVIWGIEVAEELHWKGWELGKETTRNLVLKNRSLKLQKMKYRPPKTKFFFTVIPQPIFLSPGITLTLPIVFRPLEAKEYMDQLWFEKAEGMFCVGLRATLPCHRLICRPPSLQLPMCAVGDTTEAFFCLDNVGDLPTFFTWEFSSPFQMLPATGLLEPGQASQIKVTFQPLTAVIYEVQATCWYGAGSRQRSSIQLQAVAKCAQLLVSIKHKCPEDQDAEGFQKLLYFGSVAVGCTSERQIRLHNPSAVNAPFRIEISPDELAEDQAFSCPTAHGIVLPGEKKCVSVFFHPKTLDTRTVDYCSIMPSGCASKTLLKVVGFCRGPAVSLQHYCVNFSWVNLGERSEQPLWIENQSDCTAHFQFAIDCLESVFTIRPAFGTLVGKARMTLHCAFQPTHPIICFRRVACLIHHQDPLFLDLMGTCHSDSTKPAILKPQHLTWYRTHLARGLTLYPPDILDAMLKEKKLAQDQNGALMIPIQDLEDMPAPQYPYIPPMTEFFFDGTSDITIFPPPISVEPVEVDFGACPGPEAPNPVPLCLMNHTKGKIMVVWTRRSDCPFWVTPESCDVPPLKSMAMRLHFQPPHPNCLYTVELEAFAIYKVLQSYSNIEEDCTMCPSWCLTVRARGHSYFAGFEHHIPQYSLDVPKLFPAVSSGEPTYRSLLLVNKDCKLLTFSLAPQRGSDVILRPTSGLVAPGAHQIILICTYPEGSSWKQHTFYLQCNASPQYLKEVSMYSREEPLQLKLDTHKSLYFKPTWVGCSSTSPFTFRNPSRLPLQFEWRVSEQHRKLLAVQPSRGLIQPNERLTLTWTFSPLEETKYLFQVGMWVWEAGLSPNANPAATTHYMLRLVGVGLTSSLSAKEKELAFGNVLVNSKQSRFLVLLNDGNCTLYYRLYLEQGSPEAVDNHPLALQLDRTEGSMPPRSQDTICLTACPKQRSQYSWTITYSLLSHRDNKAGEKQELCCVSLVAVYPLLSILDVSSMGSAEGITRKHLWRLFSLDLLNSYLERDPTPCELTYKVPTRHSMSQIPPVLTPLRLDFNFGAAPFKAPPSVVFLALKNSGVVSLDWAFLLPSDQRIDVELWAEQAELNSTELHQMRVQDNCLFSISPKAGSLSPGQEQMVELKYSHLFIGTDHLPVLFKVSHGREILLNFIGVTVKPEQKYVHFTSTTHQFIPIPIGDTLPPRQIYELYNGGSVPVTYEVQTDVLSQVQEKNFDHPIFCCLNPKGEIQPGSTARVLWIFSPIEAKTYTVDVPIHILGWNSALIHFQGVGYNPHMMGDTAPFHNISSWDNSSIHSRLVVPGQNVFLSQSHISLGNIPVQSKCSRLLFLNNISKNEEIAFSWQPSPLDFGEVSVSPMIGVVAPEETVPFVVTLRASVHASFYSADLVCKLYSQQLMRQYHKELQEWKDEKVRQEVEFTITDMKVKKRTCCTACEPARKYKTLPPIKNQQSVSRPASWKLQTPKEEVSWPCPQPPSPGMLCLGLTARAHATDYFLANFFSEFPCHFLHRELPKRKAPREESETSEEKSPNKWGPVSKQKKQLLVDILTTIIRGLLEDKNFHEAVDQSLVEQVPYFRQFWNEQSTKFMDQKNSLYLMPILPVPSSSWEDGKGKQPKEDRPEHYPGLGKKEEGEEEKGEEEEEELEEEEEEEEETEEEELGKEEIEEKEEERDEKEEKVSWAGIGPTPQPESQESMQWQWQQQLNVMVKEEQEQDEKEAIRRLPAFANLQEALLENMIQNILVEASRGEVVLTSRPRVIALPPFCVPRSLTPDTLLPTQQAEVLHPVVPLPTDLP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 46 | Phosphorylation | VQKKQAESKSQIKLH HHHHHHCCHHCEEEE | - | ||
| 69 | Phosphorylation | CPKDMMLTQAPSSVV CCCHHEECCCCHHHH | 23403867 | ||
| 73 | Phosphorylation | MMLTQAPSSVVRSRN HEECCCCHHHHHCCC | 23403867 | ||
| 74 | Phosphorylation | MLTQAPSSVVRSRNS EECCCCHHHHHCCCC | 23403867 | ||
| 85 | Phosphorylation | SRNSRNHTVNSGGSC CCCCCCCCCCCCCCC | - | ||
| 177 | Ubiquitination | NRSLKLQKMKYRPPK CCCCCCCCCCCCCCC | - | ||
| 366 | Phosphorylation | EGFQKLLYFGSVAVG HHHHHHHHHCCEEEC | - | ||
| 431 | Acetylation | VSVFFHPKTLDTRTV EEEEECCCCCCCCEE | 19809933 | ||
| 511 | Phosphorylation | DCLESVFTIRPAFGT HHHHHCCEEECCCHH | 24719451 | ||
| 577 | Phosphorylation | ILKPQHLTWYRTHLA CCCCCHHHHHHHHHH | - | ||
| 579 | Phosphorylation | KPQHLTWYRTHLARG CCCHHHHHHHHHHCC | - | ||
| 699 (in isoform 4) | Phosphorylation | - | 26471730 | ||
| 702 (in isoform 4) | Phosphorylation | - | 26471730 | ||
| 753 (in isoform 5) | Phosphorylation | - | 26471730 | ||
| 756 (in isoform 5) | Phosphorylation | - | 26471730 | ||
| 870 | Phosphorylation | YLKEVSMYSREEPLQ HHHHHHCCCCCCCCC | 20049867 | ||
| 930 | Phosphorylation | KLLAVQPSRGLIQPN HEEEEECCCCCCCCC | - | ||
| 1072 | Phosphorylation | TACPKQRSQYSWTIT EECCCCCHHCEEEEH | 24719451 | ||
| 1074 | Phosphorylation | CPKQRSQYSWTITYS CCCCCHHCEEEEHHH | 24719451 | ||
| 1075 | Phosphorylation | PKQRSQYSWTITYSL CCCCHHCEEEEHHHH | 24043423 | ||
| 1077 | Phosphorylation | QRSQYSWTITYSLLS CCHHCEEEEHHHHHH | 24043423 | ||
| 1079 | Phosphorylation | SQYSWTITYSLLSHR HHCEEEEHHHHHHCC | 24043423 | ||
| 1080 | Phosphorylation | QYSWTITYSLLSHRD HCEEEEHHHHHHCCC | 24043423 | ||
| 1081 | Phosphorylation | YSWTITYSLLSHRDN CEEEEHHHHHHCCCC | 24719451 | ||
| 1084 | Phosphorylation | TITYSLLSHRDNKAG EEHHHHHHCCCCCCC | 24043423 | ||
| 1100 | Phosphorylation | KQELCCVSLVAVYPL CCHHHHHHHHHHHHH | 24275569 | ||
| 1109 | Phosphorylation | VAVYPLLSILDVSSM HHHHHHHHHHCHHCC | 24275569 | ||
| 1118 | Phosphorylation | LDVSSMGSAEGITRK HCHHCCCCCCCCCHH | 24275569 | ||
| 1139 | Phosphorylation | SLDLLNSYLERDPTP CHHHHHHHHHHCCCC | - | ||
| 1151 | Phosphorylation | PTPCELTYKVPTRHS CCCCEEEEECCCCCC | - | ||
| 1155 | Phosphorylation | ELTYKVPTRHSMSQI EEEEECCCCCCHHCC | 25921289 | ||
| 1158 | Phosphorylation | YKVPTRHSMSQIPPV EECCCCCCHHCCCCC | 25921289 | ||
| 1160 | Phosphorylation | VPTRHSMSQIPPVLT CCCCCCHHCCCCCCC | 27251275 | ||
| 1167 | Phosphorylation | SQIPPVLTPLRLDFN HCCCCCCCCEEEEEC | 27251275 | ||
| 1246 | Phosphorylation | SISPKAGSLSPGQEQ EECCCCCCCCCCCHH | - | ||
| 1248 | Phosphorylation | SPKAGSLSPGQEQMV CCCCCCCCCCCHHHE | - | ||
| 1509 | Phosphorylation | FVVTLRASVHASFYS EEEEEEEEEEHHHCC | 29523821 | ||
| 1513 | Phosphorylation | LRASVHASFYSADLV EEEEEEHHHCCHHHH | 29523821 | ||
| 1515 | Phosphorylation | ASVHASFYSADLVCK EEEEHHHCCHHHHHH | 29523821 | ||
| 1516 | Phosphorylation | SVHASFYSADLVCKL EEEHHHCCHHHHHHH | 29523821 | ||
| 1551 | Phosphorylation | VRQEVEFTITDMKVK HHHEEEEEEECCCCC | 25690035 | ||
| 1553 | Phosphorylation | QEVEFTITDMKVKKR HEEEEEEECCCCCCC | 25690035 | ||
| 1589 | Phosphorylation | QSVSRPASWKLQTPK CCCCCCCCCCCCCCH | 24719451 | ||
| 1594 | Phosphorylation | PASWKLQTPKEEVSW CCCCCCCCCHHHCCC | 24719451 | ||
| 1653 | Phosphorylation | RKAPREESETSEEKS CCCCCCCCCCCCCCC | 26657352 | ||
| 1655 | Phosphorylation | APREESETSEEKSPN CCCCCCCCCCCCCCC | 26657352 | ||
| 1656 | Phosphorylation | PREESETSEEKSPNK CCCCCCCCCCCCCCC | 26657352 | ||
| 1715 | Phosphorylation | RQFWNEQSTKFMDQK HHHHHHHCCCHHCCC | - | ||
| 1736 | Phosphorylation | PILPVPSSSWEDGKG EEECCCCCCCCCCCC | - | ||
| 1899 | Phosphorylation | PPFCVPRSLTPDTLL CCCCCCCCCCCCCCC | 30622161 | ||
| 1901 | Phosphorylation | FCVPRSLTPDTLLPT CCCCCCCCCCCCCCC | 30622161 | ||
| 1904 | Phosphorylation | PRSLTPDTLLPTQQA CCCCCCCCCCCCCCC | 30622161 | ||
| 1908 | Phosphorylation | TPDTLLPTQQAEVLH CCCCCCCCCCCCCCC | 25693802 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CFA65_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CFA65_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CFA65_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| PUR2_HUMAN | GART | physical | 26344197 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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