ACSF4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACSF4_HUMAN
• UniProt AC: Q4L235
• Protein Name: Beta-alanine-activating enzyme {ECO:0000250|UniProtKB:Q80WC9}
• Gene Name: AASDH
• Organism: Homo sapiens (Human).
• Sequence Length: 1098
• Protein Description: Covalently binds beta-alanine in an ATP-dependent manner to form a thioester bond with its phosphopantetheine group and transfers it to an, as yet, unknown acceptor. May be required for a post-translational protein modification or for post-transcriptional modification of an RNA..
• Protein Sequence: MTLQELVHKAASCYMDRVAVCFDECNNQLPVYYTYKTVVNAASELSNFLLLHCDFQGIREIGLYCQPGIDLPSWILGILQVPAAYVPIEPDSPPSLSTHFMKKCNLKYILVEKKQINKFKSFHETLLNYDTFTVEHNDLVLFRLHWKNTEVNLMLNDGKEKYEKEKIKSISSEHVNEEKAEEHMDLRLKHCLAYVLHTSGTTGIPKIVRVPHKCIVPNIQHFRVLFDITQEDVLFLASPLTFDPSVVEIFLALSSGASLLIVPTSVKLLPSKLASVLFSHHRVTVLQATPTLLRRFGSQLIKSTVLSATTSLRVLALGGEAFPSLTVLRSWRGEGNKTQIFNVYGITEVSSWATIYRIPEKTLNSTLKCELPVQLGFPLLGTVVEVRDTNGFTIQEGSGQVFLGGRNRVCFLDDEVTVPLGTMRATGDFVTVKDGEIFFLGRKDSQIKRHGKRLNIELVQQVAEELQQVESCAVTWYNQEKLILFMVSKDASVKEYIFKELQKYLPSHAVPDELVLIDSLPFTSHGKIDVSELNKIYLNYINLKSENKLSGKEDLWEKLQYLWKSTLNLPEDLLRVPDESLFLNSGGDSLKSIRLLSEIEKLVGTSVPGLLEIILSSSILEIYNHILQTVVPDEDVTFRKSCATKRKLSDINQEEASGTSLHQKAIMTFTCHNEINAFVVLSRGSQILSLNSTRFLTKLGHCSSACPSDSVSQTNIQNLKGLNSPVLIGKSKDPSCVAKVSEEGKPAIGTQKMELHVRWRSDTGKCVDASPLVVIPTFDKSSTTVYIGSHSHRMKAVDFYSGKVKWEQILGDRIESSACVSKCGNFIVVGCYNGLVYVLKSNSGEKYWMFTTEDAVKSSATMDPTTGLIYIGSHDQHAYALDIYRKKCVWKSKCGGTVFSSPCLNLIPHHLYFATLGGLLLAVNPATGNVIWKHSCGKPLFSSPQCCSQYICIGCVDGNLLCFTHFGEQVWQFSTSGPIFSSPCTSPSEQKIFFGSHDCFIYCCNMKGHLQWKFETTSRVYATPFAFHNYNGSNEMLLAAASTDGKVWILESQSGQLQSVYELPGEVFSSPVVLESMLIIGCRDNYVYCLDLLGGNQK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Ubiquitination	TLQELVHKAASCYMD CHHHHHHHHHHHHHC	37.86	-
164	Acetylation	DGKEKYEKEKIKSIS CCHHHHHHHHHHHCC	62.31	7704309
168	Ubiquitination	KYEKEKIKSISSEHV HHHHHHHHHCCHHHC	53.45	-
194	Phosphorylation	RLKHCLAYVLHTSGT HHHHHHHHHHHCCCC	7.21	22817900
271	Phosphorylation	TSVKLLPSKLASVLF CCHHCCCHHHHHHHH	40.03	24719451
338	Phosphorylation	WRGEGNKTQIFNVYG ECCCCCCEEEEEEEC	30.78	46156199
499	Ubiquitination	SVKEYIFKELQKYLP CHHHHHHHHHHHHCC	48.21	-
535	Ubiquitination	IDVSELNKIYLNYIN ECHHHHHHHHHEECC	45.40	-
550	Phosphorylation	LKSENKLSGKEDLWE CCCCCCCCCCHHHHH	49.80	29391485
552	Ubiquitination	SENKLSGKEDLWEKL CCCCCCCCHHHHHHH	44.68	-
589	O-(pantetheine 4'-phosphoryl)serine	FLNSGGDSLKSIRLL CCCCCCCHHHHHHHH	40.76	-
589	Phosphorylation	FLNSGGDSLKSIRLL CCCCCCCHHHHHHHH	40.76	-
591	Acetylation	NSGGDSLKSIRLLSE CCCCCHHHHHHHHHH	48.03	20167786
644	Phosphorylation	TFRKSCATKRKLSDI CCCHHHCCCCCHHHC	35.39	46156205
649	Phosphorylation	CATKRKLSDINQEEA HCCCCCHHHCCHHHH	39.21	25159151
657	Phosphorylation	DINQEEASGTSLHQK HCCHHHHCCCCCCCC	45.97	23927012
659	Phosphorylation	NQEEASGTSLHQKAI CHHHHCCCCCCCCEE	26.14	23927012
660	Phosphorylation	QEEASGTSLHQKAIM HHHHCCCCCCCCEEE	27.64	23927012
698	Ubiquitination	NSTRFLTKLGHCSSA CCCCHHHHCCCCCCC	55.40	-
698	Acetylation	NSTRFLTKLGHCSSA CCCCHHHHCCCCCCC	55.40	26051181
724	Phosphorylation	QNLKGLNSPVLIGKS CCCCCCCCCEEEECC	22.79	30266825
765	Acetylation	RWRSDTGKCVDASPL EEECCCCCCCCCCCE	32.93	26051181
781	Phosphorylation	VIPTFDKSSTTVYIG EEEECCCCCCEEEEC	34.46	26270265
782	Phosphorylation	IPTFDKSSTTVYIGS EEECCCCCCEEEECC	33.56	26270265
783	Phosphorylation	PTFDKSSTTVYIGSH EECCCCCCEEEECCC	27.63	26270265
784	Phosphorylation	TFDKSSTTVYIGSHS ECCCCCCEEEECCCC	17.17	26270265
786	Phosphorylation	DKSSTTVYIGSHSHR CCCCCEEEECCCCCC	9.47	26270265
789	Phosphorylation	STTVYIGSHSHRMKA CCEEEECCCCCCEEE	16.56	26270265
791	Phosphorylation	TVYIGSHSHRMKAVD EEEECCCCCCEEEEE	17.93	26270265
803	Ubiquitination	AVDFYSGKVKWEQIL EEEECCCCCCHHHHH	34.40	-
831 (in isoform 3)	Ubiquitination	-	1.29	-
866	Phosphorylation	SATMDPTTGLIYIGS CCCCCCCCCEEEEEC	35.07	22210691
870	Phosphorylation	DPTTGLIYIGSHDQH CCCCCEEEEECCCCC	12.31	50558291
873	Phosphorylation	TGLIYIGSHDQHAYA CCEEEEECCCCCEEE	17.84	22210691
879	Phosphorylation	GSHDQHAYALDIYRK ECCCCCEEEEEEEEC	12.94	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACSF4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACSF4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACSF4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ACSF4_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.