MT1H_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MT1H_HUMAN
• UniProt AC: P80294
• Protein Name: Metallothionein-1H
• Gene Name: MT1H
• Organism: Homo sapiens (Human).
• Sequence Length: 61
• Protein Description: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids..
• Protein Sequence: MDPNCSCEAGGSCACAGSCKCKKCKCTSCKKSCCSCCPLGCAKCAQGCICKGASEKCSCCA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDPNCSCE -------CCCCCCCC	20.42	8119276
6	Phosphorylation	--MDPNCSCEAGGSC --CCCCCCCCCCCCC	22.95	26503514
12	Phosphorylation	CSCEAGGSCACAGSC CCCCCCCCCCCCCCC	9.53	26503514
18	Phosphorylation	GSCACAGSCKCKKCK CCCCCCCCCCCCCCC	7.59	26503514
27	Phosphorylation	KCKKCKCTSCKKSCC CCCCCCCCCCCCCCC	23.74	28258704
28	Phosphorylation	CKKCKCTSCKKSCCS CCCCCCCCCCCCCCC	33.15	28258704
32	Phosphorylation	KCTSCKKSCCSCCPL CCCCCCCCCCCCCCC	13.07	28985074
35	Phosphorylation	SCKKSCCSCCPLGCA CCCCCCCCCCCCCCC	24.07	28857561
56	Ubiquitination	ICKGASEKCSCCA-- EECCCCCCCCCCC--	29.02	-
58	Phosphorylation	KGASEKCSCCA---- CCCCCCCCCCC----	24.25	25072903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MT1H_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MT1H_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MT1H_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MT1H_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Induction by zinc of specific metallothionein isoforms in humanmonocytes.";
Pauwels M., van Weyenbergh J., Soumillion A., Proost P., Ley M.;
Eur. J. Biochem. 220:105-110(1994).
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-31, AND PROTEIN SEQUENCE OF 1-30.
PubMed: 8119276