dbPTM

AL3A1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	AL3A1_HUMAN
UniProt AC	P30838
Protein Name	Aldehyde dehydrogenase, dimeric NADP-preferring
Gene Name	ALDH3A1
Organism	Homo sapiens (Human).
Sequence Length	453
Subcellular Localization	Cytoplasm .
Protein Description	ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids. [PubMed: 1737758 Preferentially oxidizes aromatic aldehyde substrates]
Protein Sequence	MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSKISEAVK ------CCHHHHHHH	38.40	20068231
2	Acetylation	------MSKISEAVK ------CCHHHHHHH	38.40	22814378
3	Acetylation	-----MSKISEAVKR -----CCHHHHHHHH	49.29	19608861
5	Phosphorylation	---MSKISEAVKRAR ---CCHHHHHHHHHH	24.20	22496350
163	Phosphorylation	QYLDKDLYPVINGGV HHHCCCCHHHHCCCC	12.94	110743635
178	Acetylation	PETTELLKERFDHIL CCHHHHHHHHCCEEE	60.51	19608861
178	Ubiquitination	PETTELLKERFDHIL CCHHHHHHHHCCEEE	60.51	19608861
186	Phosphorylation	ERFDHILYTGSTGVG HHCCEEEEECCCCHH	14.41	71735
194	Acetylation	TGSTGVGKIIMTAAA ECCCCHHHHHHHHHH	27.01	19608861
198	Phosphorylation	GVGKIIMTAAAKHLT CHHHHHHHHHHHHCC	11.61	110743641
202	Acetylation	IIMTAAAKHLTPVTL HHHHHHHHHCCCEEE	34.13	25825284
205	Phosphorylation	TAAAKHLTPVTLELG HHHHHHCCCEEEEEC	18.55	110743647
208	Phosphorylation	AKHLTPVTLELGGKS HHHCCCEEEEECCCC	18.73	22817900
214	Ubiquitination	VTLELGGKSPCYVDK EEEEECCCCCCCCCC	49.80	-
221	Ubiquitination	KSPCYVDKNCDLDVA CCCCCCCCCCCCCHH	49.81	-
269	Ubiquitination	EKLKKSLKEFYGEDA HHHHHHHHHHHCCHH	53.52	19608861
269	Acetylation	EKLKKSLKEFYGEDA HHHHHHHHHHHCCHH	53.52	19608861
272	Phosphorylation	KKSLKEFYGEDAKKS HHHHHHHHCCHHHHH	22.24	110743653
277	Ubiquitination	EFYGEDAKKSRDYGR HHHCCHHHHHCCHHH	64.70	-
287	Phosphorylation	RDYGRIISARHFQRV CCHHHHHCHHHHHHH	19.51	24719451
302	Ubiquitination	MGLIEGQKVAYGGTG HHHHCCEEEECCCCC	39.42	-
305	Phosphorylation	IEGQKVAYGGTGDAA HCCEEEECCCCCCHH	21.05	18083107
399	Phosphorylation	IVHITLHSLPFGGVG EEEEEEECCCCCCCC	40.63	46162019
427	Phosphorylation	ETFSHRRSCLVRPLM CCCCCCCCEEEEECC	16.26	28188228
443	Phosphorylation	DEGLKVRYPPSPAKM CCCCCEECCCCCCCC	23.60	29396449
446	Phosphorylation	LKVRYPPSPAKMTQH CCEECCCCCCCCCCC	32.74	27422710

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	FBXL12	Q9NXK8	PMID:26124079

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of AL3A1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of AL3A1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SRF_HUMAN	SRF	physical	21988832
CYHR1_HUMAN	CYHR1	physical	21988832
FXL12_HUMAN	FBXL12	physical	26124079
ZN446_HUMAN	ZNF446	physical	28514442
AL3A2_HUMAN	ALDH3A2	physical	28514442
IGLL5_HUMAN	IGLL5	physical	28514442
H2A2C_HUMAN	HIST2H2AC	physical	28514442
RCCD1_HUMAN	RCCD1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of AL3A1_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-3; LYS-178; LYS-194 ANDLYS-269, AND MASS SPECTROMETRY.	19608861 [Abstract]