| UniProt ID | CPPED_HUMAN | |
|---|---|---|
| UniProt AC | Q9BRF8 | |
| Protein Name | Serine/threonine-protein phosphatase CPPED1 | |
| Gene Name | CPPED1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 314 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes.. | |
| Protein Sequence | MSAAEAGGVFHRARGRTLAAFPAEKESEWKGPFYFILGADPQFGLIKAWSTGDCDNGGDEWEQEIRLTEQAVQAINKLNPKPKFFVLCGDLIHAMPGKPWRTEQTEDLKRVLRAVDRAIPLVLVSGNHDIGNTPTAETVEEFCRTWGDDYFSFWVGGVLFLVLNSQFYENPSKCPSLKQAQDQWLDEQLSIARQRHCQHAIVFQHIPLFLESIDEDDDYYFNLSKSTRKKLADKFIHAGVKVVFSGHYHRNAGGTYQNLDMVVSSAIGCQLGRDPHGLRVVVVTAEKIVHRYYSLDELSEKGIEDDLMDLIKKK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSAAEAGGV ------CCHHHHHCC | 35.87 | 28450419 | |
| 17 | Phosphorylation | FHRARGRTLAAFPAE CCCCCCCEEEEEECC | 24.47 | 20068231 | |
| 25 | Ubiquitination | LAAFPAEKESEWKGP EEEEECCCCCCCCCC | 69.51 | 33845483 | |
| 77 | Ubiquitination | QAVQAINKLNPKPKF HHHHHHHHHCCCCCE | 43.45 | 33845483 | |
| 109 | Ubiquitination | TEQTEDLKRVLRAVD CCCHHHHHHHHHHHH | 53.43 | 22817900 | |
| 109 (in isoform 1) | Ubiquitination | - | 53.43 | 21906983 | |
| 133 | Phosphorylation | GNHDIGNTPTAETVE CCCCCCCCCCHHHHH | 19.46 | 27251275 | |
| 135 | Phosphorylation | HDIGNTPTAETVEEF CCCCCCCCHHHHHHH | 34.78 | 27251275 | |
| 178 | Ubiquitination | PSKCPSLKQAQDQWL HHHCCCHHHHHHHHH | 48.18 | - | |
| 219 | Phosphorylation | SIDEDDDYYFNLSKS CCCCCCCCEEECCHH | 19.56 | - | |
| 220 | Phosphorylation | IDEDDDYYFNLSKST CCCCCCCEEECCHHH | 7.93 | - | |
| 256 | Phosphorylation | HRNAGGTYQNLDMVV CCCCCCCCCCHHHHH | 9.93 | 27642862 | |
| 287 | Ubiquitination | VVVVTAEKIVHRYYS EEEEEHHHHHHHHCC | 47.79 | - | |
| 294 | Phosphorylation | KIVHRYYSLDELSEK HHHHHHCCHHHHHHC | 22.02 | 28348404 | |
| 308 | Sulfoxidation | KGIEDDLMDLIKKK- CCCCHHHHHHHHCC- | 5.18 | 21406390 | |
| 312 | 2-Hydroxyisobutyrylation | DDLMDLIKKK----- HHHHHHHHCC----- | 62.90 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CPPED_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CPPED_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CPPED_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SPCS_HUMAN | SEPSECS | physical | 26186194 | |
| PFKAM_HUMAN | PFKM | physical | 26344197 | |
| SPCS_HUMAN | SEPSECS | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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