| UniProt ID | RBSK_HUMAN | |
|---|---|---|
| UniProt AC | Q9H477 | |
| Protein Name | Ribokinase {ECO:0000255|HAMAP-Rule:MF_03215, ECO:0000303|PubMed:17585908} | |
| Gene Name | RBKS {ECO:0000255|HAMAP-Rule:MF_03215} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 322 | |
| Subcellular Localization | Cytoplasm . Nucleus . | |
| Protein Description | Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.. | |
| Protein Sequence | MAASGEPQRQWQEEVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTEDLRAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAPAIADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQAAGTQSSYPYKKDLPLTLF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 84 | Phosphorylation | KDSFGNDYIENLKQN CCCCCCHHHHHHHHC | 17.71 | - | |
| 256 (in isoform 2) | Phosphorylation | - | 48.08 | - | |
| 256 | Phosphorylation | PEPKHIPTEKVKAVD CCCCCCCCHHEEEEC | 48.08 | - | |
| 274 (in isoform 2) | Phosphorylation | - | 7.16 | 22210691 | |
| 294 | Phosphorylation | LEDMLNRSNFIAAVS HHHHHCCCCCEEEEE | 34.71 | 18452278 | |
| 309 | Phosphorylation | VQAAGTQSSYPYKKD EEECCCCCCCCCCCC | 31.51 | 18452278 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RBSK_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RBSK_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RBSK_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| NSF_HUMAN | NSF | physical | 26186194 | |
| PTGR3_HUMAN | ZADH2 | physical | 26186194 | |
| PHP14_HUMAN | PHPT1 | physical | 26344197 | |
| RPE_HUMAN | RPE | physical | 26344197 | |
| NSF_HUMAN | NSF | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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