BPL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BPL1_HUMAN
• UniProt AC: P50747
• Protein Name: Biotin--protein ligase
• Gene Name: HLCS
• Organism: Homo sapiens (Human).
• Sequence Length: 726
• Subcellular Localization: Cytoplasm. Mitochondrion.
• Protein Description: Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase..
• Protein Sequence: MEDRLHMDNGLVPQKIVSVHLQDSTLKEVKDQVSNKQAQILEPKPEPSLEIKPEQDGMEHVGRDDPKALGEEPKQRRGSASGSEPAGDSDRGGGPVEHYHLHLSSCHECLELENSTIESVKFASAENIPDLPYDYSSSLESVADETSPEREGRRVNLTGKAPNILLYVGSDSQEALGRFHEVRSVLADCVDIDSYILYHLLEDSALRDPWTDNCLLLVIATRESIPEDLYQKFMAYLSQGGKVLGLSSSFTFGGFQVTSKGALHKTVQNLVFSKADQSEVKLSVLSSGCRYQEGPVRLSPGRLQGHLENEDKDRMIVHVPFGTRGGEAVLCQVHLELPPSSNIVQTPEDFNLLKSSNFRRYEVLREILTTLGLSCDMKQVPALTPLYLLSAAEEIRDPLMQWLGKHVDSEGEIKSGQLSLRFVSSYVSEVEITPSCIPVVTNMEAFSSEHFNLEIYRQNLQTKQLGKVILFAEVTPTTMRLLDGLMFQTPQEMGLIVIAARQTEGKGRGGNVWLSPVGCALSTLLISIPLRSQLGQRIPFVQHLMSVAVVEAVRSIPEYQDINLRVKWPNDIYYSDLMKIGGVLVNSTLMGETFYILIGCGFNVTNSNPTICINDLITEYNKQHKAELKPLRADYLIARVVTVLEKLIKEFQDKGPNSVLPLYYRYWVHSGQQVHLGSAEGPKVSIVGLDDSGFLQVHQEGGEVVTVHPDGNSFDMLRNLILPKRR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
79	Phosphorylation	EPKQRRGSASGSEPA CCCCCCCCCCCCCCC	19.90	29255136
81	Phosphorylation	KQRRGSASGSEPAGD CCCCCCCCCCCCCCC	44.54	23927012
83	Phosphorylation	RRGSASGSEPAGDSD CCCCCCCCCCCCCCC	37.60	23927012
89	Phosphorylation	GSEPAGDSDRGGGPV CCCCCCCCCCCCCCC	28.43	23927012
119	Phosphorylation	LENSTIESVKFASAE HCCCCEEEEEECCCC	27.10	26074081
124	Phosphorylation	IESVKFASAENIPDL EEEEEECCCCCCCCC	38.97	28176443
133	Phosphorylation	ENIPDLPYDYSSSLE CCCCCCCCCCCCCHH	34.51	28450419
135	Phosphorylation	IPDLPYDYSSSLESV CCCCCCCCCCCHHHH	12.47	28450419
136	Phosphorylation	PDLPYDYSSSLESVA CCCCCCCCCCHHHHC	15.56	28450419
137	Phosphorylation	DLPYDYSSSLESVAD CCCCCCCCCHHHHCC	32.48	28450419
138	Phosphorylation	LPYDYSSSLESVADE CCCCCCCCHHHHCCC	30.16	30576142
141	Phosphorylation	DYSSSLESVADETSP CCCCCHHHHCCCCCC	28.09	28450419
146	Phosphorylation	LESVADETSPEREGR HHHHCCCCCCCCCCC	50.56	25159151
147	Phosphorylation	ESVADETSPEREGRR HHHCCCCCCCCCCCC	23.79	25159151
236	Phosphorylation	LYQKFMAYLSQGGKV HHHHHHHHHHCCCEE	8.63	-
238	Phosphorylation	QKFMAYLSQGGKVLG HHHHHHHHCCCEEEE	17.69	-
259	Phosphorylation	FGGFQVTSKGALHKT ECCEEEECCCHHHHH	30.18	-
274	Ubiquitination	VQNLVFSKADQSEVK HHHHHHCCCCCCHHH	44.51	29967540
299	Phosphorylation	QEGPVRLSPGRLQGH CCCCCEECCCCEECC	18.10	9396568
312	Ubiquitination	GHLENEDKDRMIVHV CCCCCCCCCCEEEEE	40.84	24816145
355	Phosphorylation	EDFNLLKSSNFRRYE HHHCCHHCCCCCHHH	30.40	28634120
356	Phosphorylation	DFNLLKSSNFRRYEV HHCCHHCCCCCHHHH	38.10	28634120
419	Phosphorylation	EIKSGQLSLRFVSSY CCCCCEEEEEEHHHC	15.04	24719451
459	Ubiquitination	NLEIYRQNLQTKQLG CHHHHHHHCCCCCCC	25.72	24816145
527	Phosphorylation	ALSTLLISIPLRSQL HHHHHHHHHHHHHHH	20.37	24719451
567	Ubiquitination	QDINLRVKWPNDIYY CCCCEEECCCCCCCH	50.96	-
635	Phosphorylation	LKPLRADYLIARVVT CCHHCHHHHHHHHHH	10.06	-
642	Phosphorylation	YLIARVVTVLEKLIK HHHHHHHHHHHHHHH	19.27	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BPL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BPL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BPL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACACB_HUMAN	ACACB	physical	20085763
BPL1_HUMAN	HLCS	physical	20085763
SNX27_HUMAN	SNX27	physical	21988832
TBC20_HUMAN	TBC1D20	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 253270: Holocarboxylase synthetase deficiency (HLCS deficiency)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00121: Biotin

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-147, AND MASSSPECTROMETRY.
PubMed: 18669648