TBC20_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TBC20_HUMAN
• UniProt AC: Q96BZ9
• Protein Name: TBC1 domain family member 20
• Gene Name: TBC1D20
• Organism: Homo sapiens (Human).
• Sequence Length: 403
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude..
• Protein Sequence: MALRSAQGDGPTSGHWDGGAEKADFNAKRKKKVAEIHQALNSDPTDVAALRRMAISEGGLLTDEIRRKVWPKLLNVNANDPPPISGKNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQREGLQEELIDIILLILERNPQLHYYQGYHDIVVTFLLVVGERLATSLVEKLSTHHLRDFMDPTMDNTKHILNYLMPIIDQVNPELHDFMQSAEVGTIFALSWLITWFGHVLSDFRHVVRLYDFFLACHPLMPIYFAAVIVLYREQEVLDCDCDMASVHHLLSQIPQDLPYETLISRAGDLFVQFPPSELAREAAAQQQAERTAASTFKDFELASAQQRPDMVLRQRFRGLLRPEDRTKDVLTKPRTNRFVKLAVMGLTVALGAAALAVVKSALEWAPKFQLQLFP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	SAQGDGPTSGHWDGG CCCCCCCCCCCCCCC	53.52	27251275
13	Phosphorylation	AQGDGPTSGHWDGGA CCCCCCCCCCCCCCH	31.62	27251275
87	Ubiquitination	DPPPISGKNLRQMSK CCCCCCCCCHHHHCH	46.12	2190698
87 (in isoform 1)	Ubiquitination	-	46.12	21906983
93	Phosphorylation	GKNLRQMSKDYQQVL CCCHHHHCHHHHHHH	17.65	23909892
112 (in isoform 3)	Ubiquitination	-	49.34	21906983
326	Ubiquitination	RTAASTFKDFELASA HHHHHHHHHHHHHHH	62.69	-
339	Sulfoxidation	SAQQRPDMVLRQRFR HHHHCCHHHHHHHHH	3.20	21406390
351 (in isoform 3)	Ubiquitination	-	48.05	-
361	Ubiquitination	RTKDVLTKPRTNRFV CCCCCCCCCCCCHHH	28.48	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TBC20_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TBC20_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TBC20_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615663: Warburg micro syndrome 4 (WARBM4)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.