TMPSD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMPSD_HUMAN
• UniProt AC: Q9BYE2
• Protein Name: Transmembrane protease serine 13
• Gene Name: TMPRSS13
• Organism: Homo sapiens (Human).
• Sequence Length: 586
• Subcellular Localization: Membrane ; Single-pass type II membrane protein .
• Protein Sequence: MERDSHGNASPARTPSAGASPAQASPAGTPPGRASPAQASPAQASPAGTPPGRASPAQASPAGTPPGRASPGRASPAQASPAQASPARASPALASLSRSSSGRSSSARSASVTTSPTRVYLVRATPVGAVPIRSSPARSAPATRATRESPGTSLPKFTWREGQKQLPLIGCVLLLIALVVSLIILFQFWQGHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCVRFDWDKSLLKIYSGSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYNSTIQESLHRSECPSQRYISLQCSHCGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEGWKVYAGTSNLHQLPEAASIAEIIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYSKMEVRSLQQDTAPSRLGTSSGGDPGGAPRV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MERDSHGNASPA ---CCCCCCCCCCCC	39.24	-
29	Phosphorylation	AQASPAGTPPGRASP CCCCCCCCCCCCCCC	28.54	24719451
49	Phosphorylation	AQASPAGTPPGRASP CCCCCCCCCCCCCCC	28.54	28348404
60	Phosphorylation	RASPAQASPAGTPPG CCCCCCCCCCCCCCC	11.82	22210691
64	Phosphorylation	AQASPAGTPPGRASP CCCCCCCCCCCCCCC	28.54	33259812
70	Phosphorylation	GTPPGRASPGRASPA CCCCCCCCCCCCCHH	26.90	23898821
75	Phosphorylation	RASPGRASPAQASPA CCCCCCCCHHHCCCC	21.29	22210691
85	Phosphorylation	QASPAQASPARASPA HCCCCCCCCCHHCHH	12.73	22210691
90	Phosphorylation	QASPARASPALASLS CCCCCHHCHHHHHHH	27.94	28348404
95	Phosphorylation	RASPALASLSRSSSG HHCHHHHHHHCCCCC	35.38	27174698
97	Phosphorylation	SPALASLSRSSSGRS CHHHHHHHCCCCCCC	35.12	24719451
99	Phosphorylation	ALASLSRSSSGRSSS HHHHHHCCCCCCCCC	31.97	28348404
100	Phosphorylation	LASLSRSSSGRSSSA HHHHHCCCCCCCCCC	27.02	28348404
101	Phosphorylation	ASLSRSSSGRSSSAR HHHHCCCCCCCCCCC	29.02	28348404
104	Phosphorylation	SRSSSGRSSSARSAS HCCCCCCCCCCCCCC	25.31	23663014
105	Phosphorylation	RSSSGRSSSARSASV CCCCCCCCCCCCCCC	11.49	23663014
106	Phosphorylation	SSSGRSSSARSASVT CCCCCCCCCCCCCCC	22.65	23663014
109	Phosphorylation	GRSSSARSASVTTSP CCCCCCCCCCCCCCC	30.47	23663014
111	Phosphorylation	SSSARSASVTTSPTR CCCCCCCCCCCCCCE	23.33	23663014
113	Phosphorylation	SARSASVTTSPTRVY CCCCCCCCCCCCEEE	20.61	23663014
114	Phosphorylation	ARSASVTTSPTRVYL CCCCCCCCCCCEEEE	4.82	23663014
115	Phosphorylation	RSASVTTSPTRVYLV CCCCCCCCCCEEEEE	9.01	23663014
117	Phosphorylation	ASVTTSPTRVYLVRA CCCCCCCCEEEEEEE	1.83	23663014
120	Phosphorylation	TTSPTRVYLVRATPV CCCCCEEEEEEEECC	14.14	-
125	Phosphorylation	RVYLVRATPVGAVPI EEEEEEEECCCCEEC	3.13	27251275
134	Phosphorylation	VGAVPIRSSPARSAP CCCEECCCCCCCCCC	40.48	23898821
135	Phosphorylation	GAVPIRSSPARSAPA CCEECCCCCCCCCCC	7.68	27251275
139	Phosphorylation	IRSSPARSAPATRAT CCCCCCCCCCCCCCC	35.75	25394399
146	Phosphorylation	SAPATRATRESPGTS CCCCCCCCCCCCCCC	36.90	25394399
149	Phosphorylation	ATRATRESPGTSLPK CCCCCCCCCCCCCCC	5.55	26546556
152	O-linked_Glycosylation	ATRESPGTSLPKFTW CCCCCCCCCCCCCCC	8.17	30620550
152	Phosphorylation	ATRESPGTSLPKFTW CCCCCCCCCCCCCCC	8.17	28348404
153	Phosphorylation	TRESPGTSLPKFTWR CCCCCCCCCCCCCCC	29.73	24719451
234	Phosphorylation	VRFDWDKSLLKIYSG EEEECCHHHEEECCC	12.85	24719451
255	N-linked_Glycosylation	PICSSNWNDSYSEKT ECCCCCCCCCCCHHH	44.12	UniProtKB CARBOHYD
292	N-linked_Glycosylation	SFSILRYNSTIQESL HHHHHEECHHHHHHH	51.95	UniProtKB CARBOHYD
298	Phosphorylation	YNSTIQESLHRSECP ECHHHHHHHHHCCCC	50.86	-
302	Phosphorylation	IQESLHRSECPSQRY HHHHHHHCCCCCCCE	27.60	-
306	Phosphorylation	LHRSECPSQRYISLQ HHHCCCCCCCEEEEE	11.94	-
405	N-linked_Glycosylation	AEIIINSNYTDEEDD EEHHHCCCCCCCCCC	60.02	UniProtKB CARBOHYD
421	Phosphorylation	DIALMRLSKPLTLSA HEEEHHCCCCEEEEE	5.84	24719451
445	N-linked_Glycosylation	HGQTFSLNETCWITG CCCEEEECCEEEEEC	2.69	UniProtKB CARBOHYD
459	Phosphorylation	GFGKTRETDDKTSPF CCCCCCCCCCCCCHH	21.28	-
463	Phosphorylation	TRETDDKTSPFLREV CCCCCCCCCHHHHEE	42.28	23403867
464	Phosphorylation	RETDDKTSPFLREVQ CCCCCCCCHHHHEEE	39.18	23403867
483	Phosphorylation	DFKKCNDYLVYDSYL CHHHCCCEEEEECCC	12.35	23663014
486	Phosphorylation	KCNDYLVYDSYLTPR HCCCEEEEECCCCCC	10.70	23663014
488	Phosphorylation	NDYLVYDSYLTPRMM CCEEEEECCCCCCEE	21.89	23663014
489	Phosphorylation	DYLVYDSYLTPRMMC CEEEEECCCCCCEEE	2.45	23663014
491	Phosphorylation	LVYDSYLTPRMMCAG EEEECCCCCCEEECC	2.53	23663014
505	Ubiquitination	GDLRGGRDSCQGDSG CCCCCCCCCCCCCCC	20.45	25015289
506	Phosphorylation	DLRGGRDSCQGDSGG CCCCCCCCCCCCCCC	53.10	-
511	Ubiquitination	RDSCQGDSGGPLVCE CCCCCCCCCCCEEEE	3.67	25015289
524	Phosphorylation	CEQNNRWYLAGVTSW EECCCEEEEEEEEEC	20.18	26434776
529	Phosphorylation	RWYLAGVTSWGTGCG EEEEEEEEECCCCCC	15.04	26434776
530	Phosphorylation	WYLAGVTSWGTGCGQ EEEEEEEECCCCCCC	4.16	26434776
533	Phosphorylation	AGVTSWGTGCGQRNK EEEEECCCCCCCCCC	38.12	26434776
540	Ubiquitination	TGCGQRNKPGVYTKV CCCCCCCCCCCEEEH	19.34	25015289
544	Phosphorylation	QRNKPGVYTKVTEVL CCCCCCCEEEHHHHH	45.07	26267517
546	Ubiquitination	NKPGVYTKVTEVLPW CCCCCEEEHHHHHHH	2.07	25015289
562	Phosphorylation	YSKMEVRSLQQDTAP HHHHHHHHHCCCCCC	35.81	29083192
567	Phosphorylation	VRSLQQDTAPSRLGT HHHHCCCCCCHHCCC	11.71	29083192
570	Phosphorylation	LQQDTAPSRLGTSSG HCCCCCCHHCCCCCC	25.78	29083192
574	Phosphorylation	TAPSRLGTSSGGDPG CCCHHCCCCCCCCCC	42.04	29083192
575	Phosphorylation	APSRLGTSSGGDPGG CCHHCCCCCCCCCCC	46.52	29083192
576	Phosphorylation	PSRLGTSSGGDPGGA CHHCCCCCCCCCCCC	50.03	29083192

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMPSD_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMPSD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMPSD_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TMPSD_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.