CLIC3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLIC3_HUMAN
• UniProt AC: O95833
• Protein Name: Chloride intracellular channel protein 3
• Gene Name: CLIC3
• Organism: Homo sapiens (Human).
• Sequence Length: 236
• Subcellular Localization: Nucleus. Membrane; Single-pass membrane protein. Cytoplasm. Predominantly nuclear. Some protein was found in the cytoplasm. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity)
• Protein Description: Can insert into membranes and form chloride ion channels. May participate in cellular growth control..
• Protein Sequence: MAETKLQLFVKASEDGESVGHCPSCQRLFMVLLLKGVPFTLTTVDTRRSPDVLKDFAPGSQLPILLYDSDAKTDTLQIEDFLEETLGPPDFPSLAPRYRESNTAGNDVFHKFSAFIKNPVPAQDEALYQQLLRALARLDSYLRAPLEHELAGEPQLRESRRRFLDGDRLTLADCSLLPKLHIVDTVCAHFRQAPIPAELRGVRRYLDSAMQEKEFKYTCPHSAEILAAYRPAVHPR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Phosphorylation	LLKGVPFTLTTVDTR HHCCCCEEEEECCCC	19.68	27251275
42	Phosphorylation	KGVPFTLTTVDTRRS CCCCEEEEECCCCCC	23.01	23090842
43	Phosphorylation	GVPFTLTTVDTRRSP CCCEEEEECCCCCCC	21.35	23090842
46	Phosphorylation	FTLTTVDTRRSPDVL EEEEECCCCCCCCHH	24.52	23090842
49	Phosphorylation	TTVDTRRSPDVLKDF EECCCCCCCCHHHHC	23.35	30278072
54	Ubiquitination	RRSPDVLKDFAPGSQ CCCCCHHHHCCCCCC	51.12	-
93	Phosphorylation	LGPPDFPSLAPRYRE HCCCCCCCCCHHHHH	36.84	24719451
128	Phosphorylation	PAQDEALYQQLLRAL CCCCHHHHHHHHHHH	10.97	-
159	Phosphorylation	GEPQLRESRRRFLDG CCCCHHHHHHHHCCC	25.34	20146363
175	Phosphorylation	RLTLADCSLLPKLHI CEEHHHHHHHCCCEE	33.22	24905233
205	Phosphorylation	ELRGVRRYLDSAMQE HHHHHHHHHHHHHHH	12.33	28348404
208	Phosphorylation	GVRRYLDSAMQEKEF HHHHHHHHHHHHHCC	24.05	22985185
229	Phosphorylation	SAEILAAYRPAVHPR HHHHHHHHCCCCCCC	16.12	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CLIC3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLIC3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLIC3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
EFHC2_HUMAN	EFHC2	physical	25416956
SPS2_HUMAN	SEPHS2	physical	26344197

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.