GPR52_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GPR52_HUMAN
• UniProt AC: Q9Y2T5
• Protein Name: G-protein coupled receptor 52 {ECO:0000312|HGNC:HGNC:4508}
• Gene Name: GPR52 {ECO:0000303|PubMed:9931487, ECO:0000312|HGNC:HGNC:4508}
• Organism: Homo sapiens (Human).
• Sequence Length: 361
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Gs-coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization. [PubMed: 24587241 May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum]
• Protein Sequence: MNESRWTEWRILNMSSGIVNVSERHSCPLGFGHYSVVDVCIFETVVIVLLTFLIIAGNLTVIFVFHCAPLLHHYTTSYFIQTMAYADLFVGVSCLVPTLSLLHYSTGVHESLTCQVFGYIISVLKSVSMACLACISVDRYLAITKPLSYNQLVTPCRLRICIILIWIYSCLIFLPSFFGWGKPGYHGDIFEWCATSWLTSAYFTGFIVCLLYAPAAFVVCFTYFHIFKICRQHTKEINDRRARFPSHEVDSSRETGHSPDRRYAMVLFRITSVFYMLWLPYIIYFLLESSRVLDNPTLSFLTTWLAISNSFCNCVIYSLSNSVFRLGLRRLSETMCTSCMCVKDQEAQEPKPRKRANSCSI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	N-linked_Glycosylation	------MNESRWTEW ------CCHHHHHHH	56.82	UniProtKB CARBOHYD
13	N-linked_Glycosylation	WTEWRILNMSSGIVN HHHHHHHCCCCCCEE	26.39	UniProtKB CARBOHYD
20	N-linked_Glycosylation	NMSSGIVNVSERHSC CCCCCCEEHHHHCCC	29.67	UniProtKB CARBOHYD
234	Phosphorylation	FKICRQHTKEINDRR HHHHHHHHHHHHHHH	23.26	27174698
281	Nitration	FYMLWLPYIIYFLLE HHHHHHHHHHHHHHH	9.59	-
284	Nitration	LWLPYIIYFLLESSR HHHHHHHHHHHHHCC	4.42	-
322	Phosphorylation	VIYSLSNSVFRLGLR HHHHCCCHHHHHHHH	21.18	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GPR52_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GPR52_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GPR52_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MBOA7_HUMAN	MBOAT7	physical	26186194
SNG2_HUMAN	SYNGR2	physical	26186194
ALG8_HUMAN	ALG8	physical	26186194
ARV1_HUMAN	ARV1	physical	26186194
B3A2_HUMAN	SLC4A2	physical	26186194
RFT1_HUMAN	RFT1	physical	26186194
FITM2_HUMAN	FITM2	physical	26186194
FZD2_HUMAN	FZD2	physical	26186194
PLCC_HUMAN	AGPAT3	physical	26186194
EBP_HUMAN	EBP	physical	26186194
LEG3_HUMAN	LGALS3	physical	26186194
REEP5_HUMAN	REEP5	physical	26186194
CXA1_HUMAN	GJA1	physical	26186194
CHPT1_HUMAN	CHPT1	physical	26186194
ERMP1_HUMAN	ERMP1	physical	26186194
MSMO1_HUMAN	MSMO1	physical	26186194
T179B_HUMAN	TMEM179B	physical	26186194
COX1_HUMAN	COX1	physical	26186194
LCLT1_HUMAN	LCLAT1	physical	26186194
AG10A_HUMAN	ALG10	physical	26186194
EMC10_HUMAN	EMC10	physical	26186194
LMBR1_HUMAN	LMBR1	physical	26186194
VKORL_HUMAN	VKORC1L1	physical	26186194
F189B_HUMAN	FAM189B	physical	26186194
TMM56_HUMAN	TMEM56	physical	26186194
YIPF3_HUMAN	YIPF3	physical	26186194
ALG3_HUMAN	ALG3	physical	26186194
SNG2_HUMAN	SYNGR2	physical	28514442
FITM2_HUMAN	FITM2	physical	28514442
ERMP1_HUMAN	ERMP1	physical	28514442
ALG8_HUMAN	ALG8	physical	28514442
LMBR1_HUMAN	LMBR1	physical	28514442
YIPF4_HUMAN	YIPF4	physical	28514442
EBP_HUMAN	EBP	physical	28514442
TMM56_HUMAN	TMEM56	physical	28514442
LEG3_HUMAN	LGALS3	physical	28514442
PLCC_HUMAN	AGPAT3	physical	28514442
CHPT1_HUMAN	CHPT1	physical	28514442
RETR2_HUMAN	FAM134A	physical	28514442
MBOA7_HUMAN	MBOAT7	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.